Cambridge hybrid closed-loop algorithm in children and adolescents with type 1 diabetes: a multicentre 6-month randomised controlled trial

Autor: Julia Ware, MD, Charlotte K Boughton, PhD, Janet M Allen, RN, Malgorzata E Wilinska, PhD, Martin Tauschmann, PhD, Louise Denvir, MD, Ajay Thankamony, MPhil, Fiona M Campbell, MD, R Paul Wadwa, ProfMD, Bruce A Buckingham, ProfMD, Nikki Davis, MD, Linda A DiMeglio, ProfMD, Nelly Mauras, MD, Rachel E J Besser, PhD, Atrayee Ghatak, MD, Stuart A Weinzimer, ProfMD, Korey K Hood, ProfPhD, D Steven Fox, MD, Lauren Kanapka, MSc, Craig Kollman, PhD, Judy Sibayan, MPH, Roy W Beck, PhD, Roman Hovorka, ProfPhD, R Hovorka, C L Acerini, A Thankamony, J M Allen, C K Boughton, K Dovc, D B Dunger, J Ware, G Musolino, M Tauschmann, M E Wilinska, J F Hayes, S Hartnell, S Slegtenhorst, Y Ruan, M Haydock, J Mangat, L Denvir, SK Kanthagnany, J Law, T Randell, P Sachdev, M Saxton, A Coupe, S Stafford, A Ball, R Keeton, R Cresswell, L Crate, H Cripps, H Fazackerley, L Looby, H Navarra, C Saddington, V Smith, V Verhoeven, S Bratt, N Khan, L Moyes, K Sandhu, C West, R P Wadwa, G Alonso, G Forlenza, R Slover, L Towers, C Berget, A Coakley, E Escobar, E Jost, S Lange, L Messer, K Thivener, F M Campbell, J Yong, E Metcalfe, M Allen, S Ambler, S Waheed, J Exall, J Tulip, B A Buckingham, L Ekhlaspour, D Maahs, L Norlander, T Jacobson, M Twon, C Weir, B Leverenz, J Keller, N Davis, A Kumaran, N Trevelyan, H Dewar, G Price, G Crouch, R Ensom, L Haskell, LM Lueddeke, N Mauras, M Benson, K Bird, K Englert, J Permuy, K Ponthieux, J Marrero-Hernandez, L A DiMeglio, H Ismail, H Jolivette, J Sanchez, S Woerner, M Kirchner, M Mullen, M Tebbe, R EJ Besser, S Basu, R London, T Makaya, F Ryan, C Megson, J Bowen-Morris, J Haest, R Law, I Stamford, A Ghatak, M Deakin, K Phelan, K Thornborough, J Shakeshaft, S A Weinzimer, E Cengiz, J L Sherr, M Van Name, K Weyman, L Carria, A Steffen, M Zgorski, J Sibayan, R W Beck, S Borgman, J Davis, J Rusnak, A Hellman, P Cheng, L Kanapka, C Kollman, C McCarthy, S Chalasani, K K Hood, S Hanes, J Viana, M Lanning, D S Fox, G Arreaza-Rubin, T Eggerman, N Green, R Janicek, D Gabrielson, S H Belle, J Castle, J Green, L Legault, S M Willi, C Wysham

Publikováno v: The Lancet: Digital Health, Vol 4, Iss 4, Pp e245-e255 (2022)

Summary: Background: Closed-loop insulin delivery systems have the potential to address suboptimal glucose control in children and adolescents with type 1 diabetes. We compared safety and efficacy of the Cambridge hybrid closed-loop algorithm with us

Externí odkaz: https://doaj.org/article/9bf15c000c1f41e1bce13d4bb5d7e2c3

Relationships between plasma biomarkers, tau PET, FDG PET, and volumetric MRI in mild to moderate Alzheimer's disease patients

Autor: Dawn C. Matthews, Jefferson W. Kinney, Aaron Ritter, Randolph D. Andrews, Erin N. Toledano Strom, Ana S. Lukic, Lauren N. Koenig, Carolyn Revta, Howard M. Fillit, Kate Zhong, Babak Tousi, James B. Leverenz, Howard H. Feldman, Jeffrey Cummings

Publikováno v: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 10, Iss 3, Pp n/a-n/a (2024)

Abstract INTRODUCTION The “A/T/N” (amyloid/tau/neurodegeneration) framework provides a biological basis for Alzheimer's disease (AD) diagnosis and can encompass additional changes such as inflammation (“I”). A spectrum of T/N/I imaging and pl

Externí odkaz: https://doaj.org/article/928ea7d24f9142e28dbc79c4984a4006

Metabolic syndrome biomarkers relate to rate of cognitive decline in MCI and dementia stages of Alzheimer’s disease

Autor: Jagan A. Pillai, James Bena, Lynn Bekris, Nandan Kodur, Takhar Kasumov, James B. Leverenz, Sangeeta R. Kashyap, on behalf of the Alzheimer’s Disease Neuroimaging Initiative

Publikováno v: Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-14 (2023)

Abstract Background The relationship between biomarkers of metabolic syndrome and insulin resistance, plasma triglyceride/HDL cholesterol (TG/HDL-C) ratio, on the rate of cognitive decline in mild cognitive impairment (MCI) and dementia stages of Alz

Externí odkaz: https://doaj.org/article/7f988d21051e45c7814c375edec910d8

Lewy Body Dementia Association’s Industry Advisory Council: proceedings of the second annual meeting

Autor: Jennifer G. Goldman, Bradley F. Boeve, Melissa J. Armstrong, Doug R. Galasko, James E. Galvin, David J. Irwin, James B. Leverenz, Karen Marder, Victor Abler, Kevin Biglan, Michael C. Irizarry, Bill Keller, Robert Lai, Leanne Munsie, Michael Belleville, Ondrea Chaney, Ian Richard, Angela Taylor, Todd Graham

Publikováno v: Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-4 (2021)

Abstract In 2019, the Lewy Body Dementia Association formed an Industry Advisory Council to bring together a collaborative group of stakeholders with the goal of accelerating clinical research into Lewy body dementia treatments. At the second annual

Externí odkaz: https://doaj.org/article/d059a29e453d4f58b082c0ad7f785ab1

AlzGPS: a genome-wide positioning systems platform to catalyze multi-omics for Alzheimer’s drug discovery

Autor: Yadi Zhou, Jiansong Fang, Lynn M. Bekris, Young Heon Kim, Andrew A. Pieper, James B. Leverenz, Jeffrey Cummings, Feixiong Cheng

Publikováno v: Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-13 (2021)

Abstract Background Recent DNA/RNA sequencing and other multi-omics technologies have advanced the understanding of the biology and pathophysiology of AD, yet there is still a lack of disease-modifying treatments for AD. A new approach to integration

Externí odkaz: https://doaj.org/article/57fab40ecef94245835d5030aa3bd075