Zobrazeno 1 - 10
of 92
pro vyhledávání: '"B Leppard"'
A prospective randomised comparison of minor surgery in primary and secondary care. The MiSTIC trial
Autor:
S George, P Pockney, J Primrose, H Smith, P Little, H Kinley, R Kneebone, A Lowy, B Leppard, N Jayatilleke, C McCabe
Publikováno v:
Health Technology Assessment, Vol 12, Iss 23 (2008)
Externí odkaz:
https://doaj.org/article/cc0268fe52d248739b41240605bff474
Autor:
Tapas K. Hazra, Padmini S. Kedar, Sankar Mitra, Huxian Wang, Istvan Boldogh, Rajendra Prasad, Michael Weinfeld, Samuel H. Wilson, Lee R Wiederhold, Feridoun Karimi-Busheri, John B. Leppard, Alan E. Tomkinson, Aditi Das
Publikováno v:
DNA Repair. 5:1439-1448
DNA glycosylases/AP lyases initiate repair of oxidized bases in the genomes of all organisms by excising these lesions and then cleaving the DNA strand at the resulting abasic (AP) sites and generate 3' phospho alpha,beta-unsaturated aldehyde (3' PUA
Autor:
John B. Leppard, James J. Champoux
Publikováno v:
Chromosoma. 114:75-85
Human DNA topoisomerase I is an essential enzyme involved in resolving the torsional stress associated with DNA replication, transcription, and chromatin condensation. The catalytic cycle of the enzyme consists of DNA cleavage to form a covalent enzy
Autor:
B. Leppard, A.E. Naburi
Publikováno v:
British Journal of Dermatology. 143:520-523
Background Ivermectin is a potentially useful treatment for scabies. Objectives We aimed to evaluate the efficacy of ivermectin in the treatment of scabies in an institutional environment. Methods A single dose of ivermectin 150 μg kg -1 was given u
Autor:
Jingwen Chen, Zachary B. Mackey, Claude Niedergang, Gilbert de Murcia, Alan E. Tomkinson, Josiane Ménissier-de Murcia, Karin Au, John B. Leppard
Publikováno v:
Journal of Biological Chemistry. 274:21679-21687
Mammalian DNA ligases are composed of a conserved catalytic domain flanked by unrelated sequences. At the C-terminal end of the catalytic domain, there is a 16-amino acid sequence, known as the conserved peptide, whose role in the ligation reaction i
Autor:
Patrick W. Gray, Daniel S. Allison, W. Jason Cummings, Christi L. Wood, Munehisa Yabuki, Larry W. Tjoelker, Robert M. Immormino, John B. Leppard, Nancy Maizels
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 4, p e36032 (2012)
PLoS ONE, Vol 7, Iss 4, p e36032 (2012)
Monoclonal antibodies (mAbs) can be potent and highly specific therapeutics, diagnostics and research reagents. Nonetheless, mAb discovery using current in vivo or in vitro approaches can be costly and time-consuming, with no guarantee of success. We
Autor:
B Leppard, John N. Primrose, Peter Pockney, Helen Smith, Steve George, N Jayatilleke, Roger Kneebone, A Lowy, Paul Little
Publikováno v:
British Journal of Cancer
Skin malignancy is an important cause of mortality in the United Kingdom and is rising in incidence every year. Most skin cancer presents in primary care, and an important determinant of outcome is initial recognition and management of the lesion. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb4493ced3298f1455db770bac3c5e38
https://eprints.soton.ac.uk/70053/
https://eprints.soton.ac.uk/70053/
A prospective randomised comparison of minor surgery in primary and secondary care. The MiSTIC trial
Autor:
A Lowy, B Leppard, Peter Pockney, Paul Little, Steve George, Helen Smith, Roger Kneebone, Christopher McCabe, N Jayatilleke, John N. Primrose, Helen Kinley
Publikováno v:
Health Technology Assessment, Vol 12, Iss 23 (2008)
Scopus-Elsevier
Scopus-Elsevier
Objective: To determine whether there is equivalence in the competence of GPs and hospital doctors to perform a range of elective minor surgical procedures, in terms of the safety, quality and cost of care. Design: A prospective randomised controlled
Autor:
James J. Champoux, Heidrun Interthal, Jörg Zotzmann, Thomas E. Kehl-Fie, John B. Leppard, Hong Jing Chen
Publikováno v:
The EMBO journal. 24(12)
Tyrosyl-DNA phosphodiesterase (Tdp1) catalyzes the hydrolysis of the tyrosyl-3' phosphate linkage found in topoisomerase I-DNA covalent complexes. The inherited disorder, spinocerebellar ataxia with axonal neuropathy (SCAN1), is caused by a H493R mut