Zobrazeno 1 - 10
of 12
pro vyhledávání: '"B L Seely"'
Autor:
Donna Reichart, Paulos Berhanu, B L Seely, Jerrold M. Olefsky, Alan R. Saltiel, Patricia A. Staubs, Jyotirmoy Kusari, Kim L. Milarski
Publikováno v:
Diabetes. 45:1379-1385
Protein tyrosine phosphatase 1B (PTP1B) is a protein tyrosine phosphatase of unknown function, although increasing evidence supports a role for this phosphatase in insulin action. We have investigated the interaction of PTP1B with the insulin recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f62b3762477fe84257e3f3358e4ac87
https://doi.org/10.2337/diab.45.10.1379
https://doi.org/10.2337/diab.45.10.1379
Publikováno v:
Endocrinology. 136:1635-1641
Insulin/insulin-like growth factor-I (IGF-I) hybrid receptors are composed of an alpha beta-heterodimer from an insulin receptor and an alpha beta-heterodimer from an IGF-I receptor. In this study, we evaluate the effect of insulin receptor overexpre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a395282d00e702e66ec3ef8b465767ec
https://doi.org/10.1210/endo.136.4.7895674
https://doi.org/10.1210/endo.136.4.7895674
Autor:
Jerrold M. Olefsky, D W Rose, Alan R. Saltiel, Lewis C. Cantley, Lucia E. Rameh, Byung Hak Jhun, B L Seely
Publikováno v:
Molecular and Cellular Biology. 14:7466-7475
We have investigated the functional role of the SH2 domain of the 85-kDa subunit (p85) of the phosphatidylinositol 3-kinase in the insulin signal transduction pathway. Microinjection of a bacterial fusion protein containing the N-terminal SH2 domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f502ae6a2873b837b453f4902cb6c21d
https://doi.org/10.1128/mcb.14.11.7466
https://doi.org/10.1128/mcb.14.11.7466
Autor:
Hiroshi Maegawa, B L Seely, P Berhanu, Alan R. Saltiel, K L Milarski, Jerrold M. Olefsky, Donna Reichart, Patricia A. Staubs
Publikováno v:
Journal of Biological Chemistry. 269:27186-27192
The insulin receptor is known to interact with the SH2 domain proteins p85 (the regulatory subunit of phosphatidylinositol 3-kinase), Syp (a tyrosine phosphatase), and GAP (GTPase-activating protein). In this study, we mapped the insulin receptor bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4038ca646a7df9a6e440f28026c05127
https://doi.org/10.1016/s0021-9258(18)46967-0
https://doi.org/10.1016/s0021-9258(18)46967-0
Autor:
C. L. Whitham, John J. Nolan, B. L. Seely, Gilbert Cote, T. A. Christensen, M. R. Hill, Leonard J. Deftos, P. L. Clopton, L. J. Florek
Publikováno v:
Calcified tissue international. 61(4)
Calcitonin (CT) and other bone-active peptides have been restrained in clinical use by the need for parenteral administration. Although nasal and other transmucosal routes can be used for CT treatment, bioavailability and bioactivity of the peptide t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c6b6ae68579c30d8d4199f067eea4a
https://pubmed.ncbi.nlm.nih.gov/9312206
https://pubmed.ncbi.nlm.nih.gov/9312206
Publikováno v:
Clinical chemistry. 42(9)
We describe a patient with signs and symptoms of virilization caused by 21-hydroxylase deficiency. The patient, a Hispanic woman, first sought medical attention at age 24, when she presented to a medical clinic with an uncomplicated urinary tract inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f6e532b1033f078156328bd182d7328e
https://pubmed.ncbi.nlm.nih.gov/8787709
https://pubmed.ncbi.nlm.nih.gov/8787709
Publikováno v:
Cancer research. 56(12)
There is strong evidence to suggest that insulin and insulin-like growth factor (IGF)-I may be important for tumor growth. Both the insulin and IGF-I receptors (IGF-IR) are overexpressed in breast cancer, and antibody blockade of the IGF-IR inhibits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::af65b19bb36650e5c9e81f719bcb4984
https://pubmed.ncbi.nlm.nih.gov/8665514
https://pubmed.ncbi.nlm.nih.gov/8665514
Autor:
P A, Staubs, D R, Reichart, A R, Saltiel, K L, Milarski, H, Maegawa, P, Berhanu, J M, Olefsky, B L, Seely
Publikováno v:
The Journal of biological chemistry. 269(44)
The insulin receptor is known to interact with the SH2 domain proteins p85 (the regulatory subunit of phosphatidylinositol 3-kinase), Syp (a tyrosine phosphatase), and GAP (GTPase-activating protein). In this study, we mapped the insulin receptor bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d1ea401c1d676f1a34e22696d9f5705
https://pubmed.ncbi.nlm.nih.gov/7525547
https://pubmed.ncbi.nlm.nih.gov/7525547
Autor:
B L, Seely
Publikováno v:
Medical Section proceedings : the ... annual Meeting of the Medical Section of the American Council of Life Insurance. American Council of Life Insurance. Medical Section. Meeting.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f29759751989c9bcd8c2a39b86667f20
https://pubmed.ncbi.nlm.nih.gov/7659709
https://pubmed.ncbi.nlm.nih.gov/7659709
Publikováno v:
Investigative ophthalmologyvisual science. 34(6)
To study the growth regulation of bovine corneal endothelium, the effects of insulin and insulin-like growth factor-I on the expression of the c-fos proto-oncogene as well as on DNA synthesis were analyzed. Bovine corneal endothelial cells were also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a8cbc5f9a407f1dea095b40f1b19ccb6
https://pubmed.ncbi.nlm.nih.gov/8491561
https://pubmed.ncbi.nlm.nih.gov/8491561