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Akademický článek

Characterization of mutations in the low density lipoprotein (LDL)-receptor gene in patients with homozygous familial hypercholesterolemia, and frequency of these mutations in FH patients in the United Kingdom

Autor: J C Webb, X M Sun, S N McCarthy, C Neuwirth, G R Thompson, B L Knight, A K Soutar

Publikováno v: Journal of Lipid Research, Vol 37, Iss 2, Pp 368-381 (1996)

Mutations in the gene for the low density lipoprotein (LDL) receptor have been identified in 15 patients with homozygous familial hypercholesterolemia (FH). Five patients are homozygous at the LDL-receptor locus; their mutant alleles include Glu387Ly

Externí odkaz: https://doaj.org/article/4fd1f6fe26884d86a82a968125377cbb

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Akademický článek

Partial duplication of the EGF precursor homology domain of the LDL-receptor protein causing familial hypercholesterolemia (FH-Salerno).

Autor: S Bertolini, D D Patel, D A Coviello, N Lelli, M Ghisellini, R Tiozzo, P Masturzo, N Elicio, B L Knight, S Calandra

Publikováno v: Journal of Lipid Research, Vol 35, Iss 8, Pp 1422-1430 (1994)

A novel mutation of low density lipoprotein (LDL)-receptor gene was found in an Italian family hypercholesterolemia (FH) patient during a screening of 300 FH patients. The proband as well as her daughter were found to be heterozygotes for the mutatio

Externí odkaz: https://doaj.org/article/4d955e3b2e7d44ba939b339a602bb512

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Akademický článek

The characterization of lipoproteins in the high density fraction obtained from patients with familial lecithin:cholesterol acyltransferase deficiency and their interaction with cultured human fibroblasts.

Autor: A K Soutar, B L Knight, N B Myant

Publikováno v: Journal of Lipid Research, Vol 23, Iss 3, Pp 380-390 (1982)

Lipoproteins of density 1.063--1.21 g/ml were isolated from the plasma of three sisters of Irish origin with familial LCAT deficiency. Fractionation of the lipoproteins on the basis of particle size by chromatography on Sephacryl S-300 permitted part

Externí odkaz: https://doaj.org/article/569f06716ff14ed9b50413603f2ac636

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Photometric survey of binary near-Earth asteroids

Publikováno v: Icarus
Icarus, 2006, 181, pp.63-93. ⟨10.1016/j.icarus.2005.10.014⟩

Photometric data on 17 binary near-Earth asteroids (15 of them are certain detections, two are probables) were analysed and characteristic properties of the near-Earth asteroid (NEA) binary population were inferred. We have found that binary systems

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c201cf1adc6d3841a26b3c52c472d56f
https://doi.org/10.1016/j.icarus.2005.10.014

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Treatment of aggressive testicular tumors in four dogs

Autor: R S Dhaliwal, B L Knight, B E Kitchell, B R Schmidt

Publikováno v: Journal of the American Animal Hospital Association. 35:311-318

In this report, the authors describe four dogs referred for diagnosis and treatment of unusual and aggressive testicular tumors. For the vast majority of dogs with testicular tumors, orchiectomy is curative. All dogs in this report had surgical resec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57615855c16e806cc9fb00806906b86e
https://doi.org/10.5326/15473317-35-4-311

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Treatment with atorvastatin alters the ratio of interleukin-12/interleukin-10 gene expression [corrected]

Autor: R P, Naoumova, D D, Patel, F H, O'Neill, G R, Thompson, B L, Knight

Publikováno v: European journal of clinical investigation. 33(1)

Statins have been shown to have pleiotropic effects extending beyond their ability to lower cholesterol.Seventeen patients with heterozygous familial hypercholesterolaemia participated in a single-blind placebo controlled study. The patients underwen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e2e43d71e24509536b4b64423de49edd
https://pubmed.ncbi.nlm.nih.gov/12492458

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Disturbances in the normal regulation of SREBP-sensitive genes in PPAR alpha-deficient mice

Autor: D D, Patel, B L, Knight, D, Wiggins, S M, Humphreys, G F, Gibbons

Publikováno v: Journal of lipid research. 42(3)

Peroxisome proliferator-activated receptor alpha (PPAR alpha)-null mice were used to investigate the nature of the relationship between the normal circadian rhythm of hepatic PPAR alpha expression and the expression of the lipogenic and cholesterogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::715d7b1ebc492a6bb5bcac7463f1a10d
https://pubmed.ncbi.nlm.nih.gov/11254743

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The effect of peroxisome-proliferator-activated receptor-alpha on the activity of the cholesterol 7 alpha-hydroxylase gene

Autor: D D, Patel, B L, Knight, A K, Soutar, G F, Gibbons, D P, Wade

Publikováno v: The Biochemical journal.

Cholesterol 7 alpha-hydroxylase (Cyp7a1) plays a central role in the regulation of bile acid and cholesterol metabolism, and transcription of the gene is controlled by bile acids and hormones acting through a complex interaction with a number of pote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d90cba8449eb81b178d583e7b977ff70
https://pubmed.ncbi.nlm.nih.gov/11042130

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Mechanism for elevated plasma lipoprotein(a) concentrations in patients on dialysis: turnover studies

Autor: M, Misra, D A, Reaveley, C, Cooper, E A, Brown, B L, Knight, D, Wade, M, Seed

Publikováno v: Advances in peritoneal dialysis. Conference on Peritoneal Dialysis. 14

Plasma concentrations of lipoprotein (a) [Lp(a)] are increased in patients on renal replacement therapy. Lipoprotein (a) is increasingly being recognized as an independent cardiovascular risk factor. In an effort to explore the mechanism for elevatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::968f1eb1407602cb4ce6674c026a1cfb
https://pubmed.ncbi.nlm.nih.gov/10649729

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