Výsledky vyhledávání - "B L, Largent"

Pharmacological and biochemical characterization of a recombinant human galanin GALR1 receptor: agonist character of chimeric galanin peptides

Autor: L W, Fitzgerald, J P, Patterson, D S, Conklin, R, Horlick, B L, Largent

Publikováno v: The Journal of pharmacology and experimental therapeutics. 287(2)

The galanin neuropeptide system is widely distributed throughout the brain and periphery and is thought to play a role in feeding, pain and reproduction. To evaluate the human galanin receptor 1 as a potential therapeutic target, we fully characteriz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6aca48bd460678eb02b3406b0a04e630
https://pubmed.ncbi.nlm.nih.gov/9808667

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Characterization of [125I]sauvagine binding to CRH2 receptors: membrane homogenate and autoradiographic studies

Autor: D H, Rominger, C M, Rominger, L W, Fitzgerald, R, Grzanna, B L, Largent, R, Zaczek

Publikováno v: The Journal of pharmacology and experimental therapeutics. 286(1)

We describe the binding of [125I]tyr(o)sauvagine to membranes of corticotropin-releasing hormone (CRH2) receptor expressing HEK293/EBNA (293ECRH2 alpha) cells. The binding of [125I]tyr(o)sauvagine to CRH2 receptors was temperature, time and tissue de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::84922f2cf4d23e2e59b4831e071b78a4
https://pubmed.ncbi.nlm.nih.gov/9655891

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A goldfish Notch-3 homologue is expressed in neurogenic regions of embryonic, adult, and regenerating brain and retina

Autor: S A, Sullivan, L K, Barthel, B L, Largent, P A, Raymond

Publikováno v: Developmental genetics. 20(3)

Members of the Notch gene family are thought to be involved in the regulation of cell fate decisions in a variety of embryonic tissues, particularly in the developing central nervous system (CNS) in Drosophila and vertebrates. In goldfish the CNS con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::502941b411509b6f39357327058d0383
https://pubmed.ncbi.nlm.nih.gov/9216061

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Carbohydrate-specific adhesion of alveolar macrophages to mannose-derivatized surfaces

Autor: Yuan C. Lee, R L Schnaar, C A Hoppe, B L Largent, K M Walton

Publikováno v: ResearcherID

The ability of rabbit alveolar macrophages to specifically recognize and adhere to surfaces derivatized with carbohydrates was examined. Otherwise inert polyacrylamide gels were derivatized with aminohexylglycosides as previously described (Guarnacci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d54a37935769fe0053bb4a672a08beb
https://doi.org/10.1016/s0021-9258(17)43473-9

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Carbohydrate-specific adhesion of alveolar macrophages to mannose-derivatized surfaces

Autor: B L, Largent, K M, Walton, C A, Hoppe, Y C, Lee, R L, Schnaar

Publikováno v: The Journal of biological chemistry. 259(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c2d63b69f02bbdef3d037237bedefa26
https://pubmed.ncbi.nlm.nih.gov/6693435

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Structural determinants of sigma receptor affinity

Autor: B L, Largent, H, Wikström, A L, Gundlach, S H, Snyder

Publikováno v: Molecular pharmacology. 32(6)

The structural determinants of sigma receptor affinity have been evaluated by examining a wide range of compounds related to opioids, neuroleptics, and phenylpiperidine dopaminergic structures for affinity at sigma receptor-binding sites labeled with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8c39b08c58139eafc225b0398ed66345
https://pubmed.ncbi.nlm.nih.gov/2826991

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Pharmacological and autoradiographic discrimination of sigma and phencyclidine receptor binding sites in brain with (+)-[3H]SKF 10,047, (+)-[3H]-3-[3-hydroxyphenyl]-N-(1-propyl)piperidine and [3H]-1-[1-(2-thienyl)cyclohexyl]piperidine

Autor: B L, Largent, A L, Gundlach, S H, Snyder

Publikováno v: The Journal of pharmacology and experimental therapeutics. 238(2)

The benzomorphan opioid, SKF 10,047, is the prototypical agonist for the sigma receptor. In this study, pharmacological and autoradiographic analyses reveal that (+)-[3H]SKF 10,047 labels two sites in brain: a high affinity site resembling the sigma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f0598390225e2d86fa754eb434f2b3c0
https://pubmed.ncbi.nlm.nih.gov/3016248

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Characterization of phencyclidine and sigma receptor-binding sites in brain

Autor: A L, Gundlach, B L, Largent, S H, Snyder

Publikováno v: NIDA research monograph. 64

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::02af5df8167d4bd2af2d64aeccf5da8c
https://pubmed.ncbi.nlm.nih.gov/3012343

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Selective labeling of serotonin uptake sites in rat brain by [3H]citalopram contrasted to labeling of multiple sites by [3H]imipramine

Autor: R J, D'Amato, B L, Largent, A M, Snowman, S H, Snyder

Publikováno v: The Journal of pharmacology and experimental therapeutics. 242(1)

Citalopram is a potent and selective inhibitor of neuronal serotonin uptake. In rat brain membranes [3H]citalopram demonstrates saturable and reversible binding with a KD of 0.8 nM and a maximal number of binding sites (Bmax) of 570 fmol/mg of protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::329817a4c8b36d20880f73ddfd1337b3
https://pubmed.ncbi.nlm.nih.gov/3475452

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