Zobrazeno 1 - 10
of 16
pro vyhledávání: '"B L, Kemp"'
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7(4)
Cyclooxygenase-2 (COX-2), the enzyme that converts arachidonic acid to prostaglandins, is overexpressed in a variety of different tumors, including those of the colon, pancreas, lung, and head and neck. We used in situ hybridization with a digoxgenin
Publikováno v:
Anticancer research. 20(6B)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptors play an important role in regulating apoptosis. Recently, it was shown that the expression of TRAIL-R2, also known as KILLER, Trick or DR5, can be induced by either DNA damage
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 6(8)
Previous studies have shown that the expression of the cell-cell adhesion molecule (C-CAM1), located at chromosome 19, is down-regulated in several types of human cancers, including prostate and breast cancers. Two major isoforms of C-CAM1, the long
Autor:
J M, Kurie, J S, Lee, F R, Khuri, L, Mao, R C, Morice, J J, Lee, G L, Walsh, A, Broxson, S M, Lippman, J Y, Ro, B L, Kemp, D, Liu, H A, Fritsche, X, Xu, R, Lotan, W K, Hong
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 6(8)
Lung cancer remains the number one cause of cancer-related deaths in the United States. To reduce the mortality associated with this disease, individuals at risk must be identified prior to the development of lung cancer, and effective prevention str
Publikováno v:
Cancer. 88(8)
Surveillance, Epidemiology, and End Results (SEER) data for the years 1973-1992 documented that patients age50 years presented with more advanced disease. Because of the increase in the incidence rate of lung adenocarcinoma in the past few decades an
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 6(2)
Development of non-small cell lung cancer (NSCLC) is a result of multiple accumulated genetic abnormalities. Profiles of genetic abnormalities may determine tumor behavior and impact on patient outcome. We used microsatellite markers at 3p14, 9p21, a
Publikováno v:
Cancer research. 59(19)
Abnormalities of FHIT, a candidate tumor suppressor gene at 3p14.2, have been found frequently in multiple tumor types including non-small cell lung cancer (NSCLC). To investigate whether FHIT inactivation plays a role in early lung tumorigenesis, Fh
Publikováno v:
Cancer research. 59(8)
DMBT1 is a candidate tumor suppressor gene located at 10q25.3-26.1. Homozygous deletion of the gene was found in a subset of medulloblastoma and glioblastoma multiforme; lack of expression was noted in the majority of these tumors. In adult tissues,
Publikováno v:
International journal of cancer. 79(5)
In this study, we aimed to confirm the finding that chromosome 5 aberrations are predisposing factors for lung cancer. The study population consisted of 118 previously untreated lung cancer patients and 101 healthy controls. Lymphocytes were treated
Publikováno v:
Cancer research. 58(18)
Cyclin-dependent kinases can be activated by cdc25, which removes inhibitory phosphates from tyrosine and threonine residues. At least three cdc25 genes (cdc25A, cdc25B, and cdc25C) have been identified in humans. Accumulating evidence indicates that