Zobrazeno 1 - 7 of 7 pro vyhledávání: '"B L, Bush"'
1
Optimal humanization of 1B4, an anti-CD18 murine monoclonal antibody, is achieved by correct choice of human V-region framework sequences
Autor: I I Singer, D W Kawka, J A DeMartino, B L Daugherty, K O Elliston, K Alves, B L Bush, P M Cameron, G C Cuca, P Davies
Publikováno v: The Journal of Immunology. 150:2844-2857
The murine anti-CD18 mAb 1B4 has been humanized using CDR grafting. Three VH (Gal, Jon, and New) and two VL (Rei and Len) human frameworks, whose selection was based exclusively on their sequence identity with m1B4, were used to construct five human
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76cb22d48c125731dcbf43ce40c99f69
https://doi.org/10.4049/jimmunol.150.7.2844
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3
Synthesis and use of 3-amino-4-phenyl-2-piperidones and 4-amino-2-benzazepin-3-ones as conformationally restricted phenylalanine isosteres in renin inhibitors
Autor: B. L. Bush, Thomas A. Halgren, Peter K. S. Siegl, Terry W. Schorn, D. G. Hangauer, William J. Greenlee, R. J. Lynch, S. E. De Laszlo, John J. Doyle
Publikováno v: Journal of Medicinal Chemistry. 35:833-846
The design of P2-P3 conformational restrictions in renin inhibitors by the use of a renin computer graphic model led to the synthesis of inhibitors containing N-Boc, N-acetyl, and N-phthalyl derivatives of 3(S)-amino-4(R,S)-2-piperidones and 4(S)-ami
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724f31713266f94b57ab3d5398b4cb0a
https://doi.org/10.1021/jm00083a006
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6
The statistical-thermodynamic basis for computation of binding affinities: a critical review
Autor: B L. Bush, J.A. McCammon, James A. Given, Michael K. Gilson
Publikováno v: Biophysical Journal. (3):1047-1069
Although the statistical thermodynamics of noncovalent binding has been considered in a number of theoretical papers, few methods of computing binding affinities are derived explicitly from this underlying theory. This has contributed to uncertainty
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4174c44d7488f439a5d4edb4c5699ea
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