Výsledky vyhledávání

Comparison of haemoglobin F detection by the acid elution test, flow cytometry and high-performance liquid chromatography in maternal blood samples analysed for fetomaternal haemorrhage

Autor: J. Birchall, S. Evans, B. Kumpel, E. Chambers, L. Davies

Publikováno v: Transfusion medicine (Oxford, England). 22(3)

Background and Objective: All pregnant women undergoing blood grouping at Southmead Hospital are offered haemoglobinopathy screening by high-performance liquid chromatography (HPLC). RhD-negative women who deliver RhD-positive infants are tested for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e119a3eb7e555f8fabb5d6b93e916a04
https://pubmed.ncbi.nlm.nih.gov/22429383

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Clearance of Rh D-positive red cells with monoclonal anti-D

Autor: Nevin C. Hughes-Jones, A. Thomson, G.E. Chapman, B. Kumpel, Marcela Contreras, R.S. Lane, P. L. Mollison, B. Gorick, Phyllis Teesdale

Publikováno v: The Lancet. 336:1147-1150

Two human monoclonal antibodies, one IgG3 and one IgG1, with anti-Rh D specificity, were tested for their ability to clear red cells. Samples of red cells from 12 D-positive subjects were sensitised in vitro with various amounts of antibody, the numb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96f5320ade7a2e1230912ef67635952a
https://doi.org/10.1016/0140-6736(90)92767-c

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Section 1B: Rh flow cytometry. Coordinator's report. Rhesus index and antigen density: an analysis of the reproducibility of flow cytometric determination

Autor: M Delamaire, P.-Y. Le Pennec, Martin Pisacka, B Kumpel, Béatrice Donvito, Yoshihiko Tani, Willy A. Flegel, Silvano Wendel, Makoto Uchikawa, V Čurin-Šerbec, H Ikeda, Jan R. Jørgensen, Franz F. Wagner

Publikováno v: Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine. 9(1)

Fifty-seven IgG monoclonal anti-D antibodies were evaluated in the Rh flow cytometry section, in which 12 laboratories participated. Staining protocols and a fluorescein (FITC)-conjugated Fab fragment goat anti-human IgG (H + L) as a secondary antibo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c218119e1a8166193ab2c9bc5650956
https://pubmed.ncbi.nlm.nih.gov/11889898

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PM.83 Testing For Fetomaternal Haemorrhage by Acid Elution Can Yield False Positive Results in the Presence of Elevated Maternal Fetal Haemoglobin

Autor: Deirdre Murphy, Jennifer C. Donnelly, S Campbell, F Ni Ainle, Deirdre Corcoran, A Doyle, B Kumpel

Publikováno v: Archives of Disease in Childhood - Fetal and Neonatal Edition. 98:A48.3-A48

Appropriate testing for fetomaternal haemorrhage (FMH) is critical in the prevention of morbidity and mortality due to haemolytic disease of the fetus and newborn (HDFN) in RhD negative women. The Kleihauer or acid elution (AE) test is widely used to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b987a2f67746e22beb1b0f05a97e22e8
https://doi.org/10.1136/archdischild-2013-303966.164

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Plasma half-lives and bioavailability of human monoclonal Rh D antibodies BRAD-3 and BRAD-5 following intramuscular injection into Rh D-negative volunteers

Autor: B. Kumpel, J. Goodrick, D. Pamphilon, B. Dawes, G. Chapman, I. Fraser, D. Anstee

Publikováno v: Clinical and experimental immunology. 98(1)

SUMMARY Two human MoAbs, BRAD-3 (an IgG3 anti-D) and BRAD-5 (an IgG1 anti-D), were produced from Epstein-Barr virus (EBV)-transformed B lymphoblastoid cell lines grown in hollow fibre bioreactors. Six Rh D-negative male volunteers were injected intra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed1084c0ebec823b055438f781fe915f
https://pubmed.ncbi.nlm.nih.gov/7923878

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P53 Electron Microscopical Localisation of CD61 (Beta3 Integrin) on Placental Syncytiotrophoblast Microvilli

Autor: G. White, D. Jackson, B. Kumpel, K. Sibley

Publikováno v: Transfusion Medicine. 16:47-47

Introduction Neonatal alloimmune thrombocytopenia (NAIT) due to maternal antibodies to the human platelet antigen (HPA)-1a can occur in first pregnancies. The HPA-1 polymorphism is located on platelet glycoprotein (GP)IIIa (CD61, beta3 integrin). It

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17907405b46f829a218aa3eb146b3a94
https://doi.org/10.1111/j.1365-3148.2006.00694_53.x

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Protein-sequence studies on Rh-related polypeptides suggest the presence of at least two groups of proteins which associate in the human red-cell membrane

Autor: K Ridgwell, B. Kumpel, Neil D. Avent, Michael J. A. Tanner, W. J. Mawby, D J Anstee

Publikováno v: Biochemical Journal. 256:1043-1046

The Rh D blood-group antigen forms part of a complex, involving several other polypeptides, that is deficient in the red cells of individuals who lack all the antigens of the Rh blood-group system (Rhnull red cells). These include components recogniz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a497770dc44768138e97e1ffd035075
https://doi.org/10.1042/bj2561043

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