Zobrazeno 1 - 10
of 22
pro vyhledávání: '"B K England"'
Autor:
William E. Mitch, L S Phillips, Xiaonan H. Wang, X Ding, S. R. Price, B K England, C Jurkovitz, James L. Bailey
Publikováno v:
Journal of Clinical Investigation. 98:1703-1708
In normal subjects and diabetic patients, insulin suppresses whole body proteolysis suggesting that the loss of lean body mass and muscle wasting in insulinopenia is related to increased muscle protein degradation. To document how insulinopenia affec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d233e214f8a53cc60cd5ca634b19f32
https://doi.org/10.1172/jci118968
https://doi.org/10.1172/jci118968
Autor:
B. K. England, S. R. Price
Publikováno v:
Blood Purification. 13:147-152
Malnutrition and a loss of lean body mass frequently complicate chronic renal failure. Muscle wasting in uremia is caused by increased protein degradation, decreased protein synthesis and increased branched-chain amino acid oxidation. Acidosis and gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3bbb3de9e03d87e2e90ab40223db621
https://doi.org/10.1159/000170197
https://doi.org/10.1159/000170197
Autor:
S. R. Price, William E. Mitch, S Grieber, James L. Bailey, R Medina, R. C. May, B K England, Alfred L. Goldberg
Publikováno v:
Journal of Clinical Investigation. 93:2127-2133
Metabolic acidosis often leads to loss of body protein due mainly to accelerated protein breakdown in muscle. To identify which proteolytic pathway is activated, we measured protein degradation in incubated epitrochlearis muscles from acidotic (NH4Cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eda378f816b66634414017a70d1eac4
https://doi.org/10.1172/jci117208
https://doi.org/10.1172/jci117208
Publikováno v:
American Journal of Physiology-Renal Physiology. 266:F536-F542
We have found abnormalities in Na-K-adenosine-triphosphatase (Na-K-ATPase) function in different tissues of rats with chronic renal failure (CRF). A potential mechanism for these findings is a change in Na-K-ATPase alpha- and/or beta-gene expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f76e7f4994d2c75573ec5ce569ed664
https://doi.org/10.1152/ajprenal.1994.266.4.f536
https://doi.org/10.1152/ajprenal.1994.266.4.f536
Publikováno v:
American Journal of Kidney Diseases. 23:224-228
An early response to metabolic acidosis is an increase in the degradation of muscle protein to provide the nitrogen needed to increase glutamine production so the kidney can excrete acid. In patients with renal insufficiency, this process may represe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19b5a3021499873bea0599e09596304
https://doi.org/10.1016/s0272-6386(12)80976-0
https://doi.org/10.1016/s0272-6386(12)80976-0
Publikováno v:
American Journal of Kidney Diseases. 21:91-95
Anorexia and/or a protein- and calorie-restricted diet can cause protein wasting by limiting the intake of essential amino acids (EAA) and, hence, protein synthesis. By this mechanism plus the effects of inadequate calories, restricted diets could co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db5c872f018bf218f3f7c480438f1ec
https://doi.org/10.1016/s0272-6386(12)80729-3
https://doi.org/10.1016/s0272-6386(12)80729-3
Publikováno v:
Kidney International. 42:595-601
Influence of ammonia and pH on protein and amino acid metabolism in LLC-PK 1 cells. Metabolic acidosis inhibits protein synthesis (PS) and stimulates protein degradation (PD) in muscle and cultured myocytes but causes hypertrophy of the proximal tubu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce795d18e7de4e1e31ae0a5e3c7eb96
https://doi.org/10.1038/ki.1992.323
https://doi.org/10.1038/ki.1992.323
Publikováno v:
Kidney International. 41:1535-1542
Chronic metabolic acidosis accelerates whole body proteolysis and oxidation in awake rats. Previous work has documented an acceleration of proteolysis and branched-chain amino acid oxidation when muscles from rats with chronic metabolic acidosis were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa6630b2badf15b090d8f59743762ab6
https://doi.org/10.1038/ki.1992.223
https://doi.org/10.1038/ki.1992.223
Publikováno v:
American Journal of Physiology-Cell Physiology. 260:C277-C282
Metabolic acidosis impairs protein and amino acid metabolism in rat muscle. To examine how extracellular acidification affects cellular protein turnover, we studied the BC3H1 myocyte. At pH 7.1 vs. 7.4, intracellular pH was lower; the decrease was gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be0c2519e63784a01c22af3f57b93bcf
https://doi.org/10.1152/ajpcell.1991.260.2.c277
https://doi.org/10.1152/ajpcell.1991.260.2.c277