Výsledky vyhledávání - "B K, Malhotra"

Exposure-response modeling and clinical trial simulation of the effect of tolterodine on QT intervals in healthy volunteers

Autor: K R, Sweeney, M R, Gastonguay, L, Benincosa, C L, Cronenberger, P, Glue, B K, Malhotra

Publikováno v: Drug discoveriestherapeutics. 4(1)

The objective of this analysis was to explore exposure-response modeling of data from a thorough QT (TQT) study of tolterodine in CYP2D6 extensive (EMs) and poor metabolizers (PMs). Crossover treatments of the TQT study included the recommended (2 mg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::445f875866f5f91279b35acc33f3a5c9
https://pubmed.ncbi.nlm.nih.gov/22491151

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Investigation of the distribution of EAB 515 to cortical ECF and CSF in freely moving rats utilizing microdialysis

Autor: B K, Malhotra, M, Lemaire, R J, Sawchuk

Publikováno v: Pharmaceutical research. 11(9)

A freely moving rat model was developed to study the CNS distribution of EAB 515 (S-alpha-amino-5-phosphonomethyl[1,1'-biphenyl]-3-propanoic acid). Microdialysis (MD) in the frontal cortex (FrC) and in the lateral ventricle (LV) of the rat brain was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f2023a8db369de2781e5fe6cf87dc29a
https://pubmed.ncbi.nlm.nih.gov/7816748

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