Výsledky vyhledávání

Recombinant human heterodimeric IL-15 complex displays extensive and reproducible N- and O-linked glycosylation

Autor: Jenifer Bear, Oleg Chertov, J. Lifson, Morten Thaysen-Andersen, Edward S. X. Moh, R. Sowder, J. Roser, Nicolle H. Packer, Cristina Bergamaschi, G. N. Pavlakis, B. K. Felber, Elena Chertova

Publikováno v: Glycoconj J
Europe PubMed Central

Human interleukin 15 (IL-15) circulates in blood as a stable molecular complex with the soluble IL-15 receptor alpha (sIL-15Rα). This heterodimeric IL-15:sIL-15Rα complex (hetIL-15) shows therapeutic potential by promoting the growth, mobilization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7da889fbcfecefee0bddc1d996ae0f8f
https://pubmed.ncbi.nlm.nih.gov/26563299

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Feedback regulation of human immunodeficiency virus type 1 expression by the Rev protein

Autor: B K Felber, C M Drysdale, G N Pavlakis

Publikováno v: Journal of Virology. 64:3734-3741

Rev is an essential regulatory protein of the human immunodeficiency virus type 1 (HIV-1) that affects the transport and half-life of certain viral mRNAs. Rev exerts its function via a unique element, the Rev-responsive element (RRE), located within

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56248f0217089449cf9288dac4f97dd4
https://doi.org/10.1128/jvi.64.8.3734-3741.1990

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Molecular biology of HIV-1: positive and negative regulatory elements important for virus expression

Autor: B K, Felber, G N, Pavlakis

Publikováno v: AIDS (London, England). 7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::02c5ec959f446a05f91d8ea5a017450a
https://pubmed.ncbi.nlm.nih.gov/8363803

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Sulfonic acid dyes: inhibition of the human immunodeficiency virus and mechanism of action

Autor: D J, Clanton, R A, Moran, J B, McMahon, O S, Weislow, R W, Buckheit, M G, Hollingshead, V, Ciminale, B K, Felber, G N, Pavlakis, J P, Bader

Publikováno v: Journal of acquired immune deficiency syndromes. 5(8)

Over 50 different commercially available sulfonic acid-containing dyes were analyzed for their ability to prevent HIV-1-induced cell killing and in inhibiting HIV-1 replication. Compounds of remarkably similar structure, but with differing patterns o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c0f2e1518afbfb3f958e9c24a1506b3d
https://pubmed.ncbi.nlm.nih.gov/1517963

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Structure, regulation and oncogenic mechanisms of HTLV-I and HTLV-II

Autor: G N, Pavlakis, B K, Felber, V, Ciminale, T, Unge, L, Solomin, J E, Harrison

Publikováno v: Leukemia. 6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2e298c3e486c8f6b9e5da5d98cb96393
https://pubmed.ncbi.nlm.nih.gov/1602819

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Binding of trans-dominant mutant Rev protein of human immunodeficiency virus type 1 to the cis-acting Rev-responsive element does not affect the fate of viral mRNA

Autor: D M, Benko, R, Robinson, L, Solomin, M, Mellini, B K, Felber, G N, Pavlakis

Publikováno v: The New biologist. 2(12)

The binding of Rev protein of human immunodeficiency virus type 1 (HIV-1) to the cis-acting Rev-responsive element (RRE) was compared to the binding of a trans-dominant Rev mutant. RevBL, which inhibits Rev function. Rev and RevBL expressed in bacter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::28305a664131356d2dcf8ffdcc2c4655
https://pubmed.ncbi.nlm.nih.gov/2088501

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Regulation of expression of human immunodeficiency virus

Autor: G N, Pavlakis, B K, Felber

Publikováno v: The New biologist. 2(1)

Human immunodeficiency virus (HIV), the causative agent of acquired immune deficiency syndrome (AIDS), encodes regulatory factors necessary for its expression. The study of these factors clearly indicates the importance and complexity of post-trascri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::70773b8c39e1cb6ffa96a4768d18ac8e
https://pubmed.ncbi.nlm.nih.gov/2078551

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The molecular basis of a familial apoE deficiency. An acceptor splice site mutation in the third intron of the deficient apoE gene

Autor: C, Cladaras, M, Hadzopoulou-Cladaras, B K, Felber, G, Pavlakis, V I, Zannis

Publikováno v: The Journal of biological chemistry. 262(5)

The molecular basis of the familial apoE deficiency was investigated by gene cloning and comparative expression studies of the normal and the deficient apoE gene. For the latter studies the apoE genes were placed under the control of the mouse metall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3eca4217f40c90aa497fde73f6c153b4
https://pubmed.ncbi.nlm.nih.gov/3029073

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Cross-activation of the Rex proteins of HTLV-I and BLV and of the Rev protein of HIV-1 and nonreciprocal interactions with their RNA responsive elements

Autor: B K, Felber, D, Derse, A, Athanassopoulos, M, Campbell, G N, Pavlakis

Publikováno v: The New biologist. 1(3)

The Rex regulatory proteins of human T-cell leukemia virus type I (HTLV-I) and bovine leukemia virus (BLV), and the Rev protein of human immunodeficiency virus type 1 (HIV-1), promote the cytoplasmic accumulation and translation of viral messenger mR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1d1613c034ec95a81f5626c452332b6b
https://pubmed.ncbi.nlm.nih.gov/2562124

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