Výsledky vyhledávání - "B Jyothi Lakshmi"

Akademický článek

Implication of Genetic Deletion of Wdr13 in Mice: Mild Anxiety, Better Performance in Spatial Memory Task, With Upregulation of Multiple Synaptic Proteins

Autor: Shiladitya Mitra, Ghantasala S Sameer Kumar, Vivek Tiwari, B Jyothi Lakshmi, Suman Thakur, Satish Kumar

Publikováno v: Frontiers in Molecular Neuroscience, Vol 9 (2016)

WDR13 expresses from the X chromosome and has a highly conserved coding sequence. There have been multiple associations of WDR13 with memory. However, its detailed function in context of brain and behavior remains unknown. We characterized the behavi

Externí odkaz: https://doaj.org/article/98600dca82da4363aa3198d72a6725dd

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Akademický článek

Lack of Wdr13 gene in mice leads to enhanced pancreatic beta cell proliferation, hyperinsulinemia and mild obesity.

Autor: Vijay Pratap Singh, B Jyothi Lakshmi, Shalu Singh, Vanya Shah, Sandeep Goel, D Partha Sarathi, Satish Kumar

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e38685 (2012)

WD-repeat proteins are very diverse, yet these are structurally related proteins that participate in a wide range of cellular functions. WDR13, a member of this family, is conserved from fishes to humans and localizes into the nucleus. To understand

Externí odkaz: https://doaj.org/article/f4705adb7d314a1f97bd10c18edb58b8

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Akademický článek

Absence of Wdr13 Gene Predisposes Mice to Mild Social Isolation – Chronic Stress, Leading to Depression-Like Phenotype Associated With Differential Expression of Synaptic Proteins

Autor: Shiladitya Mitra, Ghantasala S. Sameer Kumar, B. Jyothi Lakshmi, Suman Thakur, Satish Kumar

Publikováno v: Frontiers in Molecular Neuroscience, Vol 11 (2018)

We earlier reported that the male mice lacking the Wdr13 gene (Wdr13-/0) showed mild anxiety, better memory retention, and up-regulation of synaptic proteins in the hippocampus. With increasing evidences from parallel studies in our laboratory about

Externí odkaz: https://doaj.org/article/d12323a286f841c4b4a6b1c984f5c713

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Impaired liver regeneration and lipid homeostasis in CCl4 treated WDR13 deficient mice

Autor: Chandrashekaran Gurunathan, Y. Komala, B. Jyothi Lakshmi, Archana B. Siva, Arun Prakash Mishra

Publikováno v: Laboratory Animal Research, Vol 36, Iss 1, Pp 1-10 (2020)
Laboratory Animal Research

Background and AimWDR13 - a WD repeat protein, is abundant in pancreas, liver, ovary and testis. Absence of this protein in mice has been seen to be associated with pancreatic β-cell proliferation, hyperinsulinemia and age dependent mild obesity. Pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead30a7a746e2f3d148bbcf3be93de89
http://link.springer.com/article/10.1186/s42826-020-00076-8

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Molecular characterization of Wdr13 knockout female mice uteri: a model for human endometrial hyperplasia

Autor: Chaturvedula Tripura, Sivapriya Pavuluri, Bharathi Venkatachalam, Shalu Singh, B. Jyothi Lakshmi, Bhim B. Biswa, Satish Kumar

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports

Endometrial hyperplasia (EH) is a condition where uterine endometrial glands show excessive proliferation of epithelial cells that may subsequently progress into endometrial cancer (EC). Modern lifestyle disorders such as obesity, hormonal changes an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca05d9a88f2bf3200cd2e137e302541b
http://link.springer.com/article/10.1038/s41598-020-70773-w

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Absence of WDR13 in p53-Null Mice Increases Longevity

Autor: B. Jyothi Lakshmi, Arun Prakash Mishra

Absence of WDR13 is known to be involved in pancreatic, colon and uterine hyperproliferation. However, a recent study showed its antiproliferative role liver regeneration in response to hepatotoxins. These findings intrigued to study the role of WDR1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c2341ef6a385f819949843406531c9c
https://doi.org/10.21203/rs.3.rs-856707/v1