Zobrazeno 1 - 10
of 34
pro vyhledávání: '"B J R, Whittle"'
Publikováno v:
Early Phase Drug Evaluation in Man ISBN: 9781349107070
The pharmacological studies that must be conducted on a new chemical entity (NCE) to support the application for an CTX/IND or an MAA/NDA are not defined precisely by the regulatory authorities. Although most readers are probably familiar with the ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7a478efda3106a864c079b439937fe
https://doi.org/10.1201/9780367812454-3
https://doi.org/10.1201/9780367812454-3
Autor:
B J R Whittle
Publikováno v:
Gut. 47:320-325
Despite the considerable range of newly identified disease modifying approaches to the control of the inflammatory process reported over the past 10–20 years, only a few have yet gained widespread clinical acceptance. In contrast, the very recent a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a5c24eb5ac5139fe80d926b1d18304
https://doi.org/10.1136/gut.47.3.320
https://doi.org/10.1136/gut.47.3.320
Autor:
B J R Whittle, M Cavicchi
Publikováno v:
British Journal of Pharmacology. 128:705-715
The inducible isoform of nitric oxide synthase (iNOS) may be involved in the pathogenesis of inflammatory bowel disease. Using the human intestinal epithelial cell line, Caco-2, iNOS expression, regulation and sensitivity to the glucocorticoid, dexam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7e862f485c45ca7632a4d47d1e5b895
https://doi.org/10.1038/sj.bjp.0702827
https://doi.org/10.1038/sj.bjp.0702827
Autor:
C. J. Wharton, W. R. King, M. Brockwell, Paul Barraclough, A. G. Caldwell, Derek A. Demaine, C. J. Harris, R. J. Stepney, B. J. R. Whittle
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::966015960ad686774d37375a69b426c2
https://doi.org/10.1002/chin.199435280
https://doi.org/10.1002/chin.199435280
Autor:
B J R, Whittle, C, Varga, A, Berko, K, Horvath, A, Posa, J P, Riley, K A, Lundeen, A M, Fourie, P J, Dunford
Publikováno v:
British journal of pharmacology. 153(5)
Leukotriene B(4) (LTB(4)), formed by the sequential actions of the 5-lipoxygenase (5-LO) and leukotriene A(4) hydrolase (LTA(4)H), is a pro-inflammatory mediator implicated in the pathogenesis of inflammatory bowel disease. However, inhibitors of 5-L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2519fe8d3cbe17197d93d4051026cfa4
https://pubmed.ncbi.nlm.nih.gov/18157165
https://pubmed.ncbi.nlm.nih.gov/18157165
Autor:
B. L. Tepperman, B. J. R. Whittle
Publikováno v:
Drug Development ISBN: 9781617370878
Over the past decade, nitric oxide (NO) has been shown to play an unprecedented range of roles in biological systems. Diverse physiologic and pathophysiologic roles for NO have been identified, including those of a vasodilator, neurotransmitter, anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44839e7d0a0780b7331be6a01608d08d
https://doi.org/10.1007/978-1-59259-202-9_2
https://doi.org/10.1007/978-1-59259-202-9_2
Autor:
B J R Whittle, M Cavicchi
Publikováno v:
Gut. 45(3)
BACKGROUNDNitric oxide production by the inducible isoform of nitric oxide synthase (iNOS) is thought to play a role in the pathogenesis of inflammatory bowel disease along with other proinflammatory mediators.AIMSTo examine the effects of cAMP, an i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a85de2ec37a0d506b69b322b5084c2
https://pubmed.ncbi.nlm.nih.gov/10446104
https://pubmed.ncbi.nlm.nih.gov/10446104
Autor:
F. László, B. J. R. Whittle
Publikováno v:
Shock, Sepsis, and Organ Failure ISBN: 9783642636721
Septic shock involves a profound reduction of blood pressure and impairment of tissue perfusion (Bone 1991; Root and Hacobs 1991; Parillo 1990), and is the most prevalent cause of mortality in intensive care units (Parillo 1996). A common cause of se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb610e4e179ef8cd5e63770579b66dfa
https://doi.org/10.1007/978-3-642-58630-9_11
https://doi.org/10.1007/978-3-642-58630-9_11
Autor:
J. Lopez-Belmonte, B. J. R. Whittle
Publikováno v:
Der Magen ISBN: 9783540566120
Das Gefasendothel ist der Ort von Synthese und Freisetzung einer Anzahl von wirksamen biologisch aktiven Mediatoren, die sowohl schutzende als auch schadigende Wirkung auf die Magenschleimhaut haben konnen. Solche endogenen Mediatoren sind moglicherw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb2224e3fb8fbe6edc1f24adfffe7964
https://doi.org/10.1007/978-3-662-06526-6_6
https://doi.org/10.1007/978-3-662-06526-6_6
Autor:
J. Lopez-Belmonte, B. J. R. Whittle
Publikováno v:
The Stomach ISBN: 9783540566137
The vascular endothelium synthesizes and releases a number of potent biologically active mediators that can exert both protective and injurious actions on the gastric mucosa. Such endogenous mediators may be involved in the regulation of gastric muco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20b29dfeb55de5e83c8d448558329704
https://doi.org/10.1007/978-3-642-78176-6_6
https://doi.org/10.1007/978-3-642-78176-6_6