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Akademický článek

Exercise and insulin resistance in PCOS: muscle insulin signalling and fibrosis

Autor: N K Stepto, D Hiam, M Gibson-Helm, S Cassar, C L Harrison, S K Hutchison, A E Joham, B J Canny, A Moreno-Asso, B J Strauss, N Hatzirodos, R J Rodgers, H J Teede

Publikováno v: Endocrine Connections, Vol 9, Iss 4, Pp 346-359 (2020)

Objective: Mechanisms of insulin resistance in polycystic ovary syndrome (PCOS) remain ill defined, contributing to sub-optimal therapies. Recognising skeletal muscle plays a key role in glucose homeostasis we investigated early insulin signalling, i

Externí odkaz: https://doaj.org/article/a3481e1c1ddb433ab251a514d68a2e2f

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Changes in the binding characteristics of the μ, δ and κ subtypes of the opioid receptor in the hypothalamus of the normal cyclic ewe and in the ovariectomised ewe following treatment with ovarian steroids

Autor: P. J. Wright, B J Canny, Iain J. Clarke, Michael A. Cowley, B Thom

Publikováno v: Journal of Endocrinology. 149:509-518

The μ, δ and κ opioid receptor subtypes were measured across the oestrous cycle of the ewe and in ovariectomised (OVX) ewes treated with oestrogen and/or progesterone. We have used a subtype-specific opioid receptor binding assay, in which [3H]dip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5685cccfe5a48b6a8218b38251ffed94
https://doi.org/10.1677/joe.0.1490509

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Corticotropin-releasing factor, but not arginine vasopressin, stimulates concentration-dependent increases in ACTH secretion from a single corticotrope. Implications for intracellular signals in stimulus-secretion coupling

Autor: B. J. Canny, Li-Guo Jia, Denis A. Leong

Publikováno v: Journal of Biological Chemistry. 267:8325-8329

The two fundamental parameters of corticotropin (ACTH) secretion are the number of secreting corticotropes and the amount of ACTH secreted by each cell. We have measured these parameters in rat corticotropes in response to increasing concentrations o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e56b73b26d2ddc4af00babbb308e17f
https://doi.org/10.1016/s0021-9258(18)42446-5

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Sustained but not repeated acute elevation of cortisol impaired the luteinizing hormone surge, estrus, and ovulation in gilts

Autor: A I, Turner, P H, Hemsworth, B J, Canny, A J, Tilbrook

Publikováno v: Biology of reproduction. 61(3)

We tested the hypothesis that sustained and repeated acute elevation of cortisol would impair the LH surge, estrus, and ovulation in gilts. Cortisol was injected intramuscularly, to achieve a sustained elevation of plasma concentrations of cortisol,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e3769671751fe9db04730a9378cb1595
https://pubmed.ncbi.nlm.nih.gov/10456836

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Testosterone acts directly at the pituitary to regulate gonadotropin-releasing hormone-induced calcium signals in male rat gonadotropes

Autor: V A, Tobin, R P, Millar, B J, Canny

Publikováno v: Endocrinology. 138(8)

We have recently shown that castration alters GnRH-induced calcium (Ca2+) signaling in the gonadotropes of male rats. Instead of generating spike-plateau Ca2+ responses to high concentrations of GnRH (100 nM), the majority of gonadotropes from castra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2cb0eb5900b79c92f6b308530a3c777f
https://pubmed.ncbi.nlm.nih.gov/9231783

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Prostaglandin E2 acts via the hypothalamus to stimulate ACTH secretion in the fetal sheep

Autor: I R, Young, J M, Loose, F, Kleftogiannis, B J, Canny

Publikováno v: Journal of neuroendocrinology. 8(9)

Prostaglandin (PG) E2 is secreted into the fetal circulation during late gestation in the sheep. Exogenous infusion of PGE2 is associated with robust increases in the circulating concentrations of ACTH and cortisol and it has therefore been proposed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f387822e0c3fc804b5887739c9af1b46
https://pubmed.ncbi.nlm.nih.gov/8877820

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Arginine vasopressin and corticotropin releasing factor: binding to ovine anterior pituitary membranes

Autor: B. J. Canny, John W. Funder, A. I. Smith, P. J. Shen, Iain J. Clarke

Publikováno v: Endocrinology. 127(5)

In the sheep, in contrast to the rat, arginine vasopressin (AVP) is a more potent stimulus to ACTH secretion from the anterior pituitary (AP) than CRF. To further explore this difference, we have compared [3H]AVP and [125I]-[Nle21 Tyr32]ovine CRF bin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9936a5cba6d6defe193ab0dbd7790777
https://pubmed.ncbi.nlm.nih.gov/2226302

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Hippocampal glucocorticoid receptors and the regulation of ACTH secretion

Autor: B J, Canny

Publikováno v: Molecular and cellular endocrinology. 71(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0ea1eb647816ea637ee969e09b5de552
https://pubmed.ncbi.nlm.nih.gov/2163928

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Differential effects of dexamethasone treatment on lipopolysaccharide-induced testicular inflammation and reproductive hormone inhibition in adult rats

Autor: Moira K O'Bryan, B J Canny, Guck T. Ooi, Renae Martine Gow, Mark P. Hedger

Publikováno v: Monash University

A single intraperitoneal injection of lipopolysaccharide (LPS) causes a biphasic suppression of testicular steroidogenesis in adult rats, with inhibition at 6 h and 18-24 h after injection. The inhibition of steroidogenesis is independent of the redu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab545ee2480f65a4bfbf5233d869600
https://research.monash.edu/en/publications/769a24d9-0639-477e-afd0-15327c90c464

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