Zobrazeno 1 - 10
of 22
pro vyhledávání: '"B J, Waddell"'
Autor:
G E, Lash, G J, Burton, L W, Chamley, V L, Clifton, M, Constancia, I P, Crocker, V, Dantzer, G, Desoye, S, Drewlo, D G, Hemmings, S, Hiendleder, B, Kalionis, J A, Keelan, Y, Kudo, R M, Lewis, U, Manuelpillai, P, Murthi, D, Natale, C, Pfarrer, S, Robertson, R, Saffery, S, Saito, A, Sferruzzi-Perri, L, Sobrevia, B J, Waddell, C T, Roberts
Publikováno v:
Placenta. 31:S4-S20
Workshops are an important part of the annual meeting of the International Federation of Placenta Associations (IFPA). At IFPA Meeting 2009 diverse topics were discussed in twelve themed workshops. Topics covered included: immune response to pregnanc
Publikováno v:
Biology of reproduction. 63(6)
Apoptosis, or physiological cell death, is elevated in the placenta of human pregnancies complicated by fetal growth retardation, suggesting that placental apoptosis may be a key factor in the overall control of feto-placental growth. The present stu
Autor:
B J, Waddell, P J, Burton
Publikováno v:
Biology of reproduction. 62(4)
The 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD-1) enzyme catalyses the conversion of the biologically inert glucocorticoid 11-dehydrocorticosterone to active corticosterone (11-oxoreductase activity) in vivo, and it is dramatically up-reg
Autor:
P J, Burton, B J, Waddell
Publikováno v:
Biology of reproduction. 60(2)
Target cell metabolism of glucocorticoids is now recognized as an important modulator of ligand access to the glucocorticoid receptor (GR). This metabolism occurs via two distinct 11beta-hydroxysteroid dehydrogenase (11beta-HSD) enzymes (types 1 and
Publikováno v:
Endocrinology. 139(4)
Placental 11beta-hydroxysteroid dehydrogenase (11beta-HSD) regulates transplacental passage of maternal glucocorticoids to the fetus and is thus a key determinant of fetal glucocorticoid levels. It has also been proposed that placental 11beta-HSD exp
Publikováno v:
Endocrinology. 139(1)
Glucocorticoid hormone action in several target tissues is dependent not only on the expression of the glucocorticoid receptor, but also on that of the 11beta-hydroxysteroid dehydrogenase (11betaHSD) enzymes, 11betaHSD-1 and -2. In the uterus, glucoc
Publikováno v:
Biology of reproduction. 55(5)
Glucocorticoid action in several target tissues is dependent on expression of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD), and in the placenta 11 beta-HSD is thought to regulate transfer of active glucocorticoid to the fetus. This study compar
Publikováno v:
Biology of reproduction. 55(4)
The serum concentrations of progesterone and 20 alpha-hydroxypregn-4-en-3-one (20 alpha-OHP) were measured by RIA in blood draining the maternal and fetal sides of the placenta on Day 100 and Day 170 of gestation (term = Day 184) in the baboon to det
Publikováno v:
Biology of reproduction. 50(2)
In baboons as in humans, the placenta is a source of various peptides, including pregnancy-associated plasma protein-A (PAPP-A). However, our present understanding of the regulation of PAPP-A production is incomplete. We have demonstrated that after
Publikováno v:
Reproduction, Fertility and Development. 20:15
Placental oxidative stress plays a key role in the pathophysiology of placenta-related disorders in humans, most notably in preeclampsia (PE) and intrauterine growth restriction (IUGR). Protection from oxidative stress is provided by antioxidant enzy