Zobrazeno 1 - 4
of 4
pro vyhledávání: '"B J, Olszewski"'
Autor:
A. L. Metz, A. W. Gough, J.L Keiser, D. Mann, G. Loewen, T. E. Mertz, P. Knowlton, Joseph Low, S. P. Henry, Richard L Schroeder, B. J. Olszewski, D. G. Robertson, C. S. Sommers
Publikováno v:
Journal of cardiovascular pharmacology. 25(6)
CI-959 is an antiallergic/antiinflammatory agent currently in development. In rats, daily bolus intravenous administration of CI-959 at doses > or = 10 mg/kg was associated with development of cardiac hypertrophy. There was no morphologic or biochemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab0c4f1658adc56084fba0a673f506e
https://pubmed.ncbi.nlm.nih.gov/7564338
https://pubmed.ncbi.nlm.nih.gov/7564338
Publikováno v:
Federation proceedings. 43(5)
CI-906 and CI-907, new orally active nonsulfhydryl angiotensin-converting enzyme inhibitors, were examined for antihypertensive effects in unanesthetized hypertensive rats and dogs. In two-kidney, one-clip Goldblatt hypertensive rats, single oral dai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e108aaeb8b5a9fe3d703565b1e9cb93b
https://pubmed.ncbi.nlm.nih.gov/6323224
https://pubmed.ncbi.nlm.nih.gov/6323224
Autor:
M J, Ryan, F A, Bjork, D M, Cohen, L L, Coughenour, T C, Major, N P, Mathias, T E, Mertz, B J, Olszewski, R M, Singer, D B, Evans
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 238(2)
CI-926 (10(-7)-10(-6) M) selectively antagonized the contraction of isolated rabbit aortae to phenylephrine and displaced the alpha-1 adrenoceptor ligand WB4101 (IC50: 82 nM) in rat brain. In the spontaneously hypertensive rat, single oral doses of e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::718e810cd8cdb8a2edc8aed4bfe6130a
https://pubmed.ncbi.nlm.nih.gov/2874210
https://pubmed.ncbi.nlm.nih.gov/2874210
Autor:
M J, Ryan, D M, Boucher, D M, Cohen, A D, Essenburg, T C, Major, T E, Mertz, B J, Olszewski, A E, Randolph, R M, Singer, H R, Kaplan
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 228(2)
CI-907 is a new orally active nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor. Monoester (prodrug) and diacid forms produced concentration related ACE inhibition in guinea-pig serum (IC50 for monoester, 1.7 X 10(-7) M and for diacid, 2.6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d214ce820c1ec3ecbc3d959373bdd997
https://pubmed.ncbi.nlm.nih.gov/6319675
https://pubmed.ncbi.nlm.nih.gov/6319675