Zobrazeno 1 - 9
of 9
pro vyhledávání: '"B J, Marafino"'
Autor:
B. J. Marafino, Michael K. Pugsley
Publikováno v:
Cardiovascular Toxicology. 3:5-12
Although it seems unlikely, it has only been 20 years since the US Food and Drug Administration (FDA) approved the first recombinant protein as a therapeutic modality. Unbelievably, an average of slightly more than two approvals per year of monoclona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a2a45f3f9b8f5e6386c7e3043eb15a6
https://doi.org/10.1385/ct:3:1:5
https://doi.org/10.1385/ct:3:1:5
Autor:
R. F. Raff, R. Store, T. Graham, J. M. Fidler, G. E. Sale, B. Johnston, H. J. Deeg, M. Pepe, F. Schuening, F. R. Appelbaum, R. J. Bauer, J. D. Young, B. J. Marafino, D. G. Ando, I. A. Braude
Publikováno v:
Transplantation. 54:813-820
A novel immunosuppressant, succinyl acetone (4,6-dioxoheptanoic acid), was studied in dogs. Results with bolus intravenous injections at doses ranging from 50 to 1600 mg/kg showed dose-dependent alpha and beta half-lives, ranging from 30 to 80 min an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a57942140b499f6b4988d44ff0d41c59
https://doi.org/10.1097/00007890-199211000-00009
https://doi.org/10.1097/00007890-199211000-00009
Publikováno v:
Research communications in chemical pathology and pharmacology. 39(1)
Direct determinations indicate that some types of interferon increase the duration of hexobarbital-induced sleep time and decrease acetaminophen toxicity. Pretreatment of mice with cloned human leukocyte interferon subtype A, IFN-alpha A, did not inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::70bfe0d27a5531de697484d3fa182b29
https://pubmed.ncbi.nlm.nih.gov/6189163
https://pubmed.ncbi.nlm.nih.gov/6189163
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 216(1)
Some aspects of the in vivo disposition of [3H]doxorubicin were investigated in mice in the first 6 hr after a 5 mg/kg i.v. dose. The disappearance of radioactivity from plasma and erythrocytes was consistent with biphasic kinetics. Highest peak radi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8b4a81356caac4c53b47aa8f3947f5c6
https://pubmed.ncbi.nlm.nih.gov/7452508
https://pubmed.ncbi.nlm.nih.gov/7452508
Autor:
J I, Arroyo, S A, Apperson, C B, Cropp, B J, Marafino, T P, Monath, R B, Tesh, R E, Shope, M A, Garcia-Blanco
Publikováno v:
The American journal of tropical medicine and hygiene. 38(3)
We studied yellow fever virus infection in two species of monkey: Saimiri sciureus (squirrel monkeys) and Macaca mulatta (rhesus monkeys). Human gamma interferon was administered intravenously in five equal doses, one was given 24 hr before infection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::31f0d9f77261584c4b8292772e02688e
https://pubmed.ncbi.nlm.nih.gov/3152785
https://pubmed.ncbi.nlm.nih.gov/3152785
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 227(1)
The pharmacokinetics of two human leukocyte interferon (IFN) subtypes (IFN-alpha A and IFN-alpha D) and two molecular hybrids [IFN-alpha AD(Bgl) and IFN-alpha AD(Pvu)] was studied in rats receiving single i.v. injections, 5.0 X 10(6) I.U./kg, of thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4fac2ded260932fc5b8f6641fd7930b3
https://pubmed.ncbi.nlm.nih.gov/6620174
https://pubmed.ncbi.nlm.nih.gov/6620174
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 142(4)
The intracellular glutathione levels of two human tumor lines and seven murine tumor lines were determined in order to investigate the role of oxidant injury in tumor cell sensitivity to human rTNF (rhTNF). Correlations were found between high intrac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1dec65cd6c9f2aa0c9e6d79eeb646b0f
https://pubmed.ncbi.nlm.nih.gov/2915120
https://pubmed.ncbi.nlm.nih.gov/2915120
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 13(4)
The effects of two highly purified human leukocyte interferons (IFN-A and IFN-AD) on drug-metabolizing capacity in mice have been investigated. IFN-AD was found to produce significant changes in antipyrine half-life, assessed by analysis of 14CO2 exh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4e77b50b60b53f9b4bb0fd612f854c11
https://pubmed.ncbi.nlm.nih.gov/2863111
https://pubmed.ncbi.nlm.nih.gov/2863111
Autor:
D, Collen, J M, Stassen, B J, Marafino, S, Builder, F, De Cock, J, Ogez, D, Tajiri, D, Pennica, W F, Bennett, J, Salwa
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 231(1)
Human tissue-type plasminogen activator (t-PA), obtained by expression in mammalian cells of recombinant DNA coding for the entire sequence of t-PA (rt-PA), was compared with natural activator from melanoma cell culture (mt-PA). In an in vitro system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fed6f85de45585e442354c286d1b5673
https://pubmed.ncbi.nlm.nih.gov/6541693
https://pubmed.ncbi.nlm.nih.gov/6541693