Zobrazeno 1 - 10
of 43
pro vyhledávání: '"B J, Ledwith"'
Autor:
Stephen Pacchione, Amy B. Barnum, Jayanthi J. Wolf, Philip J. Troilo, Thomas G. Griffiths, Cindy Pauley, B J Ledwith, Laural B. Harper, Zhibin Wang, José A. Lebrón
Publikováno v:
Gene Therapy. 29:322-332
While generally referred to as "non-integrating" vectors, adenovirus vectors have the potential to integrate into host DNA via random, illegitimate (nonhomologous) recombination. The present study provides a quantitative assessment of the potential i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34e6e97f82b874b015ce241a18e64ef3
https://doi.org/10.1038/s41434-021-00278-2
https://doi.org/10.1038/s41434-021-00278-2
Autor:
B J Ledwith, Ronald Vogels, R.B. Hill, J. Lewis, Sujata Manam, C. Russo, D. Kaslow, D. Martinez, Sheila M. Galloway, R. Lardenoije, Abraham Bout, A.J. Bett, José A. Lebrón, S.V. Machotka, M. van der Kaaden, K. Brouwer, Domenico Valerio, Warren W. Nichols, Ling Chen, D. Zuidgeest, C.A. Anderson
Publisher Summary This chapter discusses the production systems of adenoviral vectors. Particular attention is paid to the generation and use of complementation cell lines that carry the El genes and emphasizes on the PER.C6 cell line, which was deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::480bd08f5a5545ff92561820c41823ba
https://doi.org/10.1016/b978-0-12-800276-6.00007-3
https://doi.org/10.1016/b978-0-12-800276-6.00007-3
Autor:
Zhibin Wang, Warren W. Nichols, Laural B. Harper, Walter J. Bagdon, Thomas G. Griffiths, B J Ledwith, Lyudmila Denisova, Philip J. Troilo, Zhutian Niu, Thy T. Follmer, Amy B. Barnum, Sujata Manam, Carolann M. Beare, Stephen Pacchione, Cindy J. Pauley
Publikováno v:
Intervirology. 43:273-281
A variety of factors could affect the frequency of integration of plasmid DNA vaccines into host cellular DNA, including DNA sequences within the plasmid, the expressed gene product (antigen), the formulation, delivery method, route of administration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d4d55e7fcb83c9a68c4ac8db5a1c6a
https://doi.org/10.1159/000053994
https://doi.org/10.1159/000053994
Publikováno v:
Annals of the New York Academy of Sciences. 660:124-135
The therapeutic use of antisense DNA has started a revolution in pharmacology. As a model system for demonstrating the therapeutic power of the antisense concept, we sought to interrupt signal transduction in H-ras transformed cells to attempt to dow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1779bf91193b681b7cd6dc8ffed2533
https://doi.org/10.1111/j.1749-6632.1992.tb21065.x
https://doi.org/10.1111/j.1749-6632.1992.tb21065.x
Publikováno v:
Molecular and Cellular Biology. 10:1545-1555
Several lines of evidence have suggested that c-fos may act downstream from c-Ha-ras in a growth-regulatory signal transduction pathway. We used antisense RNA to inhibit c-fos gene expression and investigated the effects of diminished c-fos expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1f22f184611558073771a49c65cb029
https://doi.org/10.1128/mcb.10.4.1545
https://doi.org/10.1128/mcb.10.4.1545
Autor:
B J, Ledwith, C L, Lanning, L A, Gumprecht, C A, Anderson, J B, Coleman, N T, Gatto, G, Balasubramanian, G M, Farris, R K, Kemp, L B, Harper, A B, Barnum, S J, Pacchione, K L, Mauer, P F J, Troilo, E R, Brown, J J, Wolf, J A, Lebronl, J A, Lewis, W W, Nichols
Publikováno v:
Developments in biologicals. 123
PER.C6, a cell line derived from human embryonic retinal cells transformed with the Adenovirus Type 5 (Ad5) E1A and E1B genes, is used to produce E1-deleted Ad5 vectors such as the MRKAd5 HIV-1 gag vaccine. While whole, live PER.C6 cells are capable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bed460962ebdf9480963e6d2308b3076
https://pubmed.ncbi.nlm.nih.gov/16566451
https://pubmed.ncbi.nlm.nih.gov/16566451
Autor:
J A, Lebron, P J, Troilol, S, Pacchione, T G, Griffiths, L B, Harper, L A, Mixson, B E, Jackson, L, Michna, A B, Barnum, L, Denisova, C N, Johnson, K L, Maurer, S, Morgan-Hoffman, Z, Niu, D F, Roden, Z, Wang, J J, Wolf, T R, Hamilton, K M, Laux, K A, Soper, B J, Ledwith
Publikováno v:
Developments in biologicals. 123
Although there is a WHO guidance for a limit on residual DNA for parenterally administered vaccines produced on continuous cell lines, there is no corresponding guidance for oral vaccines. To help determine an oral limit, we performed a study of Vero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a309704ce82203d5c0f9368519f81013
https://pubmed.ncbi.nlm.nih.gov/16566435
https://pubmed.ncbi.nlm.nih.gov/16566435
Publikováno v:
Expert review of vaccines. 4(6)
There is an abundance of vaccines currently in development, with most of them exploring novel mechanisms, adjuvants and/or delivery systems not only for traditional prophylactic use, but also for therapeutic uses. As vaccines are generally administer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a6ca71dd537964f157c4858fc3ee56
https://pubmed.ncbi.nlm.nih.gov/16372881
https://pubmed.ncbi.nlm.nih.gov/16372881
Autor:
B J, Ledwith, S, Manam, P J, Troilo, A B, Barnum, C J, Pauley, T G, Griffiths, L B, Harper, H B, Schock, H, Zhang, J E, Faris, P A, Way, C M, Beare, W J, Bagdon, W W, Nichols
Publikováno v:
Developments in biologicals. 104
The primary safety concern for DNA vaccines is their potential to integrate into host cellular DNA. We describe a sensitive and quantitative assay for investigating the tissue distribution and integration of plasmid DNA vaccines. By including gonadal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::89f73036bec69a1eb316ae8e6134ac37
https://pubmed.ncbi.nlm.nih.gov/11713822
https://pubmed.ncbi.nlm.nih.gov/11713822
Publikováno v:
Cancer research. 60(3)
Peroxisome proliferators (PPs) act as nongenotoxic tumor promoters in rodents. Their hepatocarcinogenicity requires the presence of the PP-activated receptor alpha (PPARalpha); however, the exact role played by this transcription factor in the liver,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c7ef45615b03377de85c8a7eadf20f76
https://pubmed.ncbi.nlm.nih.gov/10676640
https://pubmed.ncbi.nlm.nih.gov/10676640