Zobrazeno 1 - 10
of 83
pro vyhledávání: '"B J, Fowlkes"'
Publikováno v:
Immunity. 42(1):80-94
Summary Adaptive immune responses begin when naive CD4 + T cells engage peptide+major histocompatibility complex class II and co-stimulatory molecules on antigen-presenting cells (APCs). Notch signaling can influence effector functions in differentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b52c07be8bdfa73622032f2a1c860a4f
Publikováno v:
Immunity. 43(4):617-619
Science is a tapestry made from many small threads of information. When these strands are woven together in the right order, they produce images revealing the underlying patterns of the natural world. A few select scientists are not merely contributo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926a794b1281a38c1cbda4fdbe856533
Publikováno v:
International Immunology
Pharmacological inhibitors that block amyloid precursor protein (APP) cleavage and the formation of senile plaques are under development for the treatment of familial Alzheimer's disease. Unfortunately, many inhibitors that block gamma-secretase-medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3fb6abb3b96ac71e12655ef5075b835
https://doi.org/10.1093/intimm/dxp083
https://doi.org/10.1093/intimm/dxp083
Publikováno v:
Immunological Reviews. 209:274-283
The generation of CD4 and CD8 alphabeta T-cell lineages from CD4+ CD8+ double-positive (DP) thymocyte precursors is a complex process initiated by engagement of major histocompatibility complex (MHC) by T-cell receptor (TCR) and coreceptor. Quantitat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c300ac4463be42ffdcf4892f4004b9ff
https://doi.org/10.1111/j.0105-2896.2006.00358.x
https://doi.org/10.1111/j.0105-2896.2006.00358.x
Autor:
B. J. Fowlkes, Dalal El-Khoury, Matilde Canelles, Shoji Uehara, Paul E. Love, Sandra M. Hayes, LiQi Li
Publikováno v:
The Journal of Immunology. 176:75-84
During thymocyte development, CCR9 is expressed on late CD4−CD8− (double-negative (DN)) and CD4+CD8+ (double-positive) cells, but is subsequently down-regulated as cells transition to the mature CD4+ or CD8+ (single-positive (SP)) stage. This pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f404f4de315849d9fc114d279d61d313
https://doi.org/10.4049/jimmunol.176.1.75
https://doi.org/10.4049/jimmunol.176.1.75
Publikováno v:
Nature Immunology. 4:756-764
T cell receptor signaling is an essential factor regulating thymocyte selection, but the function of the thymic environment in this process is not clear. In mice transgenic for major histocompatibility complex class II-restricted T cell receptors, ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da0db2efc8994221091370f84545fb89
https://doi.org/10.1038/ni953
https://doi.org/10.1038/ni953
Publikováno v:
The Journal of Experimental Medicine
The T cell antigen receptor complexes expressed on alphabeta and gammadelta T cells differ not only in their respective clonotypic heterodimers but also in the subunit composition of their CD3 complexes. The gammadelta T cell receptors (TCRs) express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::552859debb1c868c0f6110591b7767bc
https://doi.org/10.1084/jem.20021196
https://doi.org/10.1084/jem.20021196
Publikováno v:
Journal of Biological Chemistry. 277:44195-44201
The familial Alzheimer's disease gene product beta-amyloid (Abeta) precursor protein (APP) is processed by the beta- and gamma-secretases to produce Abeta as well as AID (APP Intracellular Domain) which is derived from the extreme carboxyl terminus o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94ca2a5e00c70e521fd1ae4009e0ee73
https://doi.org/10.1074/jbc.m208110200
https://doi.org/10.1074/jbc.m208110200
Autor:
Chiguang Feng, Kenneth J. Woodside, Elizabeth W. Shores, B. J. Fowlkes, Dalal El-Khoury, Ronald E. Gress, Matilde Cañelles, Jan Lee, Paul E. Love, Barbara A. Vance
Publikováno v:
Scopus-Elsevier
The early activation marker, CD69, is transiently expressed on activated mature T cells and on thymocytes that are undergoing positive or negative selection in the thymus. CD69 is a member of the NK gene complex family of C-type lectin-like signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59bd76474e64e3c47724152968aac27
https://doi.org/10.1093/intimm/dxf020
https://doi.org/10.1093/intimm/dxf020
Autor:
Liming Wu, Ashish Jain, Victoria Hoffmann, Yongge Zhao, Antonia Pusso, Chi Ma, Luigi D. Notarangelo, B. J. Fowlkes
Novel inhibitor of histone acetyltransferase repressor (NIR) is a transcriptional corepressor with inhibitor of histone acetyltransferase activity and is a potent suppressor of p53. Although NIR deficiency in mice leads to early embryonic lethality,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::011787144c54e4f3f23cddc074636ebc
https://europepmc.org/articles/PMC4183277/
https://europepmc.org/articles/PMC4183277/
