Výsledky vyhledávání - "B J, Dolnick"

Measurement of low-abundance cytokine mRNA in cells of murine lymphoid organs: a new quantitative reverse transcription/polymerase chain reaction method

Autor: Erica S. Berleth, B. J. Dolnick, M. J. Ehrke, P. Ujhazy, Jane M. Meer

Publikováno v: Cancer immunology, immunotherapy : CII. 48(8)

To investigate cytokine regulation in cells of freshly excised lymphoid tissues, rigorous quantitative reverse transcription/polymerase chain reaction (QRT-PCR) assays were developed to measure attomole (10(-18) mol) amounts of the mRNA for seven cyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0f6c7a02ce0a7f25a53746a65aca879
https://pubmed.ncbi.nlm.nih.gov/10550552

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Expression of rTS correlates with altered growth regulation of thymidylate synthase

Autor: A R, Black, B J, Dolnick

Publikováno v: Cancer research. 56(4)

The recently discovered rTS gene is convergent with and overlaps the thymidylate synthase gene in the antisense orientation. K562 B1A and KB 1BT are two methotrexate-resistant cell lines that have amplified genes for dihydrofolate reductase. K562 B1A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bb4f5c8355de9a81451aa5a80ce914f7
https://pubmed.ncbi.nlm.nih.gov/8630998

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5-Fluorouracil alters dihydrofolate reductase pre-mRNA splicing as determined by quantitative polymerase chain reaction

Autor: X P, Wu, B J, Dolnick

Publikováno v: Molecular pharmacology. 44(1)

A quantitative polymerase chain reaction (PCR) assay has been developed to determine the absolute and relative amounts of each dihydrofolate reductase RNA species present at different stages of splicing (i.e., pre-mRNA, splicing intermediate, and mRN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0214ac0ea7bd22dacf68659df99a0dc6
https://pubmed.ncbi.nlm.nih.gov/8341275

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Effects of 5-fluorouracil on mRNA

Autor: B J, Dolnick, X P, Wu

Publikováno v: Advances in experimental medicine and biology. 339

Currently, there are a number of studies which suggest that FU can have pronounced effects on mRNA and its metabolism. However, the relevance of these changes to the antitumor effect of FU are still not clear. Generally, the mRNAs which have been stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6ab8a709fe188117ef7d830222258739
https://pubmed.ncbi.nlm.nih.gov/8178729

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Mutation(s) of the thymidylate synthase gene of human adenocarcinoma cells causes a thymidylate synthase-negative phenotype that can be attenuated by exogenous folates

Autor: P J, Houghton, A, Rahman, C L, Will, B J, Dolnick, J A, Houghton

Publikováno v: Cancer research. 52(3)

Biological characterization of a human colon adenocarcinoma cell line deficient in thymidylate synthase (TS-) is described. The clone, designated TS-C1/C1, was derived from the parental line GC3/C1 by selection in medium containing aminopterin, thymi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::08468da7782327d11d421c398596b134
https://pubmed.ncbi.nlm.nih.gov/1732043

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Folate-binding protein mRNA is decreased in methotrexate-resistant KB cells

Autor: C T, Hsueh, B J, Dolnick

Publikováno v: Oncology research. 4(11-12)

Folate-binding protein (FBP), a high-affinity folate receptor expressed in certain malignant and normal cell lines and tissues, is responsible for cellular transport of folate and structurally related antifolates such as methotrexate in human KB (nas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0997e4d342ee6d2367aab5af89563338
https://pubmed.ncbi.nlm.nih.gov/1299378

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