Zobrazeno 1 - 10
of 201
pro vyhledávání: '"B J, Cronin"'
Autor:
Charles F Wright, Theodore E. Liston, Rosalina Destito, Alexander V. Kuperman, Lawrence A. Reiter, Kelvin Cooper, Deborah Malloy, Fiese Eugene F, Anthony Michael Campeta, David Young Mitchell, Wayne E. Barth, Sheri L. Shamblin, Fred C. Falkner, John J. Martin, Frank W. Rusek, Diane Lynn Johnson, Ralph P. Robinson, B. J. Cronin, Kathleen M. Donahue
Publikováno v:
Journal of Medicinal Chemistry. 61:3237-3237
Ether, ester, and carbonate derivatives of the antirheumatic oxindole 1 were prepared and screened as potential prodrugs of 1. This effort led to the discovery of the (alpha-L-alanyloxy)-methyl ether and hemifumarate derivatives of 1 which deliver th
Autor:
Enrique Vazquez, Susan Deborah Lagreca, Mark Guinn, Michel Couturier, Marcus Ewing, Karl Ng, A. Morgan Stewart, Lulin Wei, Raggon Jeffrey W, Brian M. Andresen, John L. Tucker, V. John Jasys, Frank J. Urban, Garrett Moraski, Derek L. Tickner, Joel M. Hawkins, B. J. Cronin, Joseph Peter Lyssikatos, Michael D'occhio
Publikováno v:
Organic Process Research & Development. 8:643-650
As part of a fast-paced oncology program, quinolinone 1 was discovered and developed as a potent inhibitor of farnesyl transferase for the treatment of cancer. The initial synthesis, which suffered from a lengthy linear sequence and a late-stage chro
Publikováno v:
Tetrahedron Letters. 38:8479-8482
Reaction of the 2-(3-phenyl-2-propen-1-yl) oxazolines 1 and 3 with organolithium reagents leads to cyclobutane ring formation by a novel tandem carbolithiation/cyclization sequence. The products (e.g., 2a and 4a) may be hydrolyzed to the correspondin
Autor:
Steven M. Finegan, Shigeru F. Hayashi, Arthur E. Girard, J. C. Kane, R.Y. Chandrasekaran, S. A. Kaufman, N. C. Birsner, J.W. Petitpas, B.V. Yang, David A. Whipple, J.P. Lyssikatos, Catherine P. Reese, C.P. MacLelland, Barbara J. Kamicker, B. J. Cronin, S. A. Miller, Joanna Clancy, Susan A. Froshauer, Magee Thomas Victor, B. P. Dirlam, M. A. Lemay, John P. Dirlam, Scott B. Seibel, Wei-Guo Su, Linde Robert Gerald, R. R. Brooks, A. M. Belton, Mark A. Massa, K. T. Sweeney, Martha L. Minich, R. J. Howe, David Austen Perry, Shang-Poa Chang, Nicole L. Kolosko
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1139-1144
A 6a-(3′,4′-dichlorophenylamino) analog of viomycin was uncovered by a high-throughput screen against the animal health pathogen Pasteurella haemolytica, and has served as a novel lead structure for our infectious disease programs. We report here
Autor:
Lisa M. Reeves, Ralph P. Robinson, Kathleen M. Donahue, Lori L. Lopresti-Morrow, Brian P. Jones, B. J. Cronin, James P. Rizzi, Sue A. Yocum, Peter G. Mitchell
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:1725-1730
Modification of the N-carboxyalkylamine 3 by independent replacement of the P1′ NH group for CH2 and introduction of P1′ gem-cyclohexyl substitution affords compounds 5 and 6a which retain appreciable activity against MMP-1 (IC50s = 0.023 μM and
Autor:
Ralph P. Robinson, B. J. Cronin, Sue A. Yocum, Lisa M. Reeves, Kathleen M. Donahue, Lori L. Lopresti-Morrow, John A. Ragan, Peter G. Mitchell
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:1719-1724
The effect of P 1 ′ C α gem-disubstitution in a series of succinamide hydroxamate inhibitors of MMP-1 has been investigated. While in all cases P 1 ′ gem-disubstitution led to loss of potency relative to the corresponding P 1 ′ isobutyl and ph
Autor:
R P, Robinson, L A, Reiter, W E, Barth, A M, Campeta, K, Cooper, B J, Cronin, R, Destito, K M, Donahue, F C, Falkner, E F, Fiese, D L, Johnson, A V, Kuperman, T E, Liston, D, Malloy, J J, Martin, D Y, Mitchell, F W, Rusek, S L, Shamblin, C F, Wright
Publikováno v:
Journal of Medicinal Chemistry. 39:10-18
Ether, ester, and carbonate derivatives of the antirheumatic oxindole 1 were prepared and screened as potential prodrugs of 1. This effort led to the discovery of the (alpha-L-alanyloxy)-methyl ether and hemifumarate derivatives of 1 which deliver th
Publikováno v:
Journal of New Medicine. Jun2024, Vol. 55 Issue 6, p437-442. 6p.
Autor:
Diane Lynn Johnson, Anthony Michael Campeta, David Young Mitchell, Ralph P. Robinson, Lawrence A. Reiter, Alexander V. Kuperman, Kelvin Cooper, Fiese Eugene F, Sheri L. Shamblin, Wayne E. Barth, John J. Martin, Theodore E. Liston, C. F. Wright, R. Destito, Frank W. Rusek, Fred C. Falkner, B. J. Cronin, Kathleen M. Donahue, D. Malloy
Publikováno v:
ChemInform. 27
Autor:
Lori L. Lopresti-Morrow, Sue A. Yocum, Ralph P. Robinson, James P. Rizzi, Peter G. Mitchell, Brian P. Jones, Lisa M. Reeves, B. J. Cronin, Kathleen M. Donahue
Publikováno v:
ChemInform. 27