Zobrazeno 1 - 10
of 91
pro vyhledávání: '"B J, Baum"'
Autor:
Ana P. Cotrim, Congcong Zhang, CM Goldsmith, Songlin Wang, Wang Yingxin, Hu Liang, Runtao Gao, Changyu Zheng, B J Baum, Luyuan Jin, Zhao Zhu, James B. Mitchell
Publikováno v:
Oral Dis
Objective The goals of this study were to (i) establish a useful miniature pig (minipig) model for irradiation-induced oral mucositis and (ii) evaluate the effect of Tempol to prevent its development. Methods and Materials Minipigs were irradiated wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8960723dc33513c9ce04803779e0bf9
https://doi.org/10.1111/odi.12667
https://doi.org/10.1111/odi.12667
Autor:
Ana P. Cotrim, Gabor G. Illei, Mayank Tandon, Eva J. Helmerhorst, Frank G. Oppenheim, John A. Chiorini, Paola Perez, M E Billings, James E. Melvin, Nikolay P. Nikolov, Shuying Liu, Marcelo A. Catalán, B J Baum, S J Danielides, Ilias Alevizos, CM Goldsmith, Changyu Zheng, Linda McCullagh
Publikováno v:
Gene therapy
We evaluated late effects of AdhAQP1 administration in five subjects in a clinical trial for radiation-induced salivary hypofunction (http://www.clinicaltrials.gov/ct/show/NCT00372320?order=). All were identified as initially responding to human aqua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ac1065b4992f25099c98ff9b41acad
https://doi.org/10.1038/gt.2016.87
https://doi.org/10.1038/gt.2016.87
Autor:
William D. Swaim, Ana P. Cotrim, Indu S. Ambudkar, CM Goldsmith, Changyu Zheng, B J Baum, Leyla Teos, Xibao Liu
Publikováno v:
Gene Therapy. 23:572-579
Head and neck irradiation (IR) during cancer treatment causes by-stander effects on the salivary glands leading to irreversible loss of saliva secretion. The mechanism underlying loss of fluid secretion is not understood and no adequate therapy is cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05b46728e279e944573ba7c24845dbe9
https://doi.org/10.1038/gt.2016.29
https://doi.org/10.1038/gt.2016.29
Autor:
B J Baum, Corinne M. Goldsmith, L Jin, Runtao Gao, Congcong Zhang, J Zhou, Ana P. Cotrim, Changyu Zheng, Bo Hai, Xing Yan, L Guo, Zhaochen Shan, Junji Xu, Songlin Wang
Publikováno v:
Gene Therapy. 21:866-873
Patients frequently experience a loss of salivary function following irradiation (IR) for the treatment of an oral cavity and oropharyngeal cancer. Herein, we tested if transfer of fibroblast growth factor-2 (FGF2) cDNA could limit salivary dysfuncti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bff428097dd32d3f73d14b50107b0946
https://doi.org/10.1038/gt.2014.63
https://doi.org/10.1038/gt.2014.63
Publikováno v:
Oral Diseases. 17:77-82
Oral Diseases (2010) 17, 77–82 Objectives: Published studies of gene transfer to mouse salivary glands have not employed the parotid glands. Parotid glands are the likely target tissue for most clinical applications of salivary gene transfer. The p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31f3c3bafb7976759669a315934e3fe3
https://doi.org/10.1111/j.1601-0825.2010.01707.x
https://doi.org/10.1111/j.1601-0825.2010.01707.x
Autor:
Michael Eckhaus, Cynthia E. Dunbar, Ana P. Cotrim, Mark E. Metzger, Antonis Voutetakis, Timothy P. Clackson, John A. Chiorini, Robert E. Donahue, Changyu Zheng, Victor M. Rivera, Sandra Afione, B J Baum
Publikováno v:
Oral Diseases. 16:269-277
Salivary glands are useful target organs for local and systemic gene therapeutics. For such applications, the regulation of transgene expression is important. Previous studies by us in murine submandibular glands showed that a rapamycin transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69eee78c90f788d220b49cb77288f4b6
https://doi.org/10.1111/j.1601-0825.2009.01631.x
https://doi.org/10.1111/j.1601-0825.2009.01631.x
Autor:
Mark E. Metzger, Re E. Donahue, Ce E. Dunbar, Antonis Voutetakis, B J Baum, Ap P. Cotrim, Ja A. Chiorini, Sandra Afione, Changyu Zheng, Nienke Roescher, M. A. Eckhaus, Fumi Mineshiba, Wd D. Swaim
Publikováno v:
Gene Therapy. 17:50-60
Salivary glands are potentially useful target sites for multiple clinical applications of gene transfer. Previously, we have shown that serotype 2 adeno-associated viral (AAV2) vectors lead to stable gene transfer in the parotid glands of rhesus maca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::880cbeadf07f22058fec0ccc89caac2b
https://doi.org/10.1038/gt.2009.123
https://doi.org/10.1038/gt.2009.123
Autor:
Jianghua Wang, Fumi Mineshiba, Michele Papa, Victor M. Rivera, Beatrijs M. Lodde, Timothy P. Clackson, Antonis Voutetakis, B J Baum
Publikováno v:
Gene Therapy. 13:187-190
Salivary glands (SGs) appear to be a useful target site for gene therapeutics. The ability to control transgene expression is essential for clinical application. Previously, in a proof-of-concept study, we have shown that the rapamycin-inducible tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edb8e32bc26ce4e73b93b60219017073
https://doi.org/10.1038/sj.gt.3302647
https://doi.org/10.1038/sj.gt.3302647
Publikováno v:
Gene Therapy. 11:729-733
Transgene-encoded therapeutic secretory proteins can be efficiently secreted from salivary glands into saliva or the bloodstream after adenoviral (Ad)-mediated gene transfer. Since transgene expression from conventional vectors is typically unregulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27fc5ce74e7c13ed4d36c543d18ccdf1
https://doi.org/10.1038/sj.gt.3302225
https://doi.org/10.1038/sj.gt.3302225
Autor:
Vidya Sankar, Stanley R. Pillemer, B J Baum, C. J. Wheeler, Lorena Baccaglini, Jane C. Atkinson, M. Sawdey
Publikováno v:
Oral Diseases. 8:275-281
OBJECTIVE: To test the ability of two cationic lipoplexes, Vaxfectin and GAP-DLRIE/DOPE, to facilitate transfection and elicit immune responses from plasmid DNAs (pDNAs) after retrograde instillation into salivary glands. METHODS: Two pDNA expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4fe74147b46ce2ac5660fc7dc2aa938
https://doi.org/10.1034/j.1601-0825.2002.02856.x
https://doi.org/10.1034/j.1601-0825.2002.02856.x