Zobrazeno 1 - 10
of 21
pro vyhledávání: '"B I Ghanayem"'
Publikováno v:
Carcinogenesis. 18:675-680
Acrylonitrile (AN) and methacrylonitrile (MAN) are two major industrial nitriles used in the production of plastics and acrylic fibers. Whereas AN is a potent acute toxin and carcinogenic in rats, little is known regarding MAN. Current work is part o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::603f1084139c54ce117c03430e50e37a
https://doi.org/10.1093/carcin/18.4.675
https://doi.org/10.1093/carcin/18.4.675
Autor:
C Edwin, Garner, C, Sloan, S C J, Sumner, J, Burgess, J, Davis, A, Etheridge, A, Parham, B I, Ghanayem
Publikováno v:
Biology of reproduction. 76(3)
1-bromopropane (1-BrP) induces dose- and time-dependent reproductive organ toxicity and reduced sperm motility in rodents. The contribution of cytochrome P4502E1 (CYP2E1) to both 1-BrP metabolism and the induction of male reproductive toxicity was in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::742f2c804b8b84f3d2d36035238d8b89
https://pubmed.ncbi.nlm.nih.gov/17093198
https://pubmed.ncbi.nlm.nih.gov/17093198
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 289(2)
Methacrylonitrile (MAN) is a widely used aliphatic nitrile and is structurally similar to the known rat carcinogen and suspected human carcinogen acrylonitrile (AN). There is evidence that AN is metabolized via the cytochrome P-450 (CYP) 2E1. Recentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7f55ee52ec3f092579a9ee4efb893f23
https://pubmed.ncbi.nlm.nih.gov/10215687
https://pubmed.ncbi.nlm.nih.gov/10215687
Autor:
R, Langenbach, S G, Morham, H F, Tiano, C D, Loftin, B I, Ghanayem, P C, Chulada, J F, Mahler, B J, Davis, C A, Lee
Publikováno v:
Advances in experimental medicine and biology. 407
Surprisingly, disruption of the COX-1 gene resulted in generally healthy mice. This is in spite of the fact that prostaglandin levels in the tissues examined were reduced by greater than 99%. The results obtained to date with the COX-1 deficient mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c986a2a9b92951c85e1c42f893be7488
https://pubmed.ncbi.nlm.nih.gov/9321936
https://pubmed.ncbi.nlm.nih.gov/9321936
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 279(1)
Nalidixic acid (NA) is an antimicrobial drug that has been used to treat urinary tract infections. A study of NA by the National Toxicology Program indicated that chronic administration in the diet at doses equivalent to 82 and 175 mg/kg/day for rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3f555531ce6d88acdfb8f48c25b0cf74
https://pubmed.ncbi.nlm.nih.gov/8858997
https://pubmed.ncbi.nlm.nih.gov/8858997
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(10)
Omeprazole (OP) is a potent antiulcer drug that is metabolized by liver cytochrome P450 (P450) enzymes. However, the identities of the P450 isoforms responsible for its metabolism have been controversial. 5-Hydroxyomeprazole (5OH-OP) formation cosegr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c678be373c8ba7e1c9ea8868613888c7
https://pubmed.ncbi.nlm.nih.gov/8894508
https://pubmed.ncbi.nlm.nih.gov/8894508
Autor:
B I, Ghanayem, L T, Burka
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(4)
Methacrylonitrile (MAN) is structurally similar to the known carcinogen acrylonitrile (AN), has similar industrial uses, and is occasionally used as its replacement. In contrast to AN, minimal information is available on the toxicity, carcinogenicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d8f43f26709e56c50565470b082ee229
https://pubmed.ncbi.nlm.nih.gov/8801052
https://pubmed.ncbi.nlm.nih.gov/8801052
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 269(2)
Methacrylonitrile (MAN) is an industrial chemical used to manufacture plastics and elastomers. The reported p.o. LD50 of MAN is 200 to 230 mg/kg in rats and 17 mg/kg in mice. Present investigations were undertaken to further characterize MAN metaboli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fe278e4939ed55c9c3f5b8cdff36d037
https://pubmed.ncbi.nlm.nih.gov/8182524
https://pubmed.ncbi.nlm.nih.gov/8182524
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 21(2)
[14C]1,2-Bis(2,4,6-tribromophenoxy)ethane (FF-680) was administered at 0.05, 0.5, or 5% in the diet for 1 day to three groups (four rats per group) of rats, and daily at 0.05% in the diet for 10 days to another group of five rats. In addition, anothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d1b1e55fc3b7553b385b542c86daef6a
https://pubmed.ncbi.nlm.nih.gov/8097687
https://pubmed.ncbi.nlm.nih.gov/8097687
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 20(5)
Methacrylonitrile (MAN), an aliphatic nitrile used in the production of plastics and elastomers, is structurally related to the known animal carcinogen, acrylonitrile. Although MAN has potential to cause significant toxicity, minimal information is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::03551eeae53935a6f3b868116db880be
https://pubmed.ncbi.nlm.nih.gov/1358567
https://pubmed.ncbi.nlm.nih.gov/1358567