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Chitosan tablets for controlled release of theophylline: Effect of polymer?drug wet or dry blending and anionic?cationic interpolymer complex

Autor: Fwu Long Mi, Nan Leu Her, Shin Shing Shyu, Tsung B I Wong, Chih Yang Kuan

Publikováno v: Journal of Applied Polymer Science. 66:2495-2505

Chitosan tablets containing theophylline were prepared by directly compressing the wet or dry blended polymer—drug powders. The effects of the viscosity and swelling ability on the release rates of drugs were examined. The theophylline releasing ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a373ac5f1bac43eff533cff9633b32f5
https://doi.org/10.1002/(sici)1097-4628(19971226)66:13<2495::aid-app12>3.0.co

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Phase 2 studies of adenosine cardioplegia

Autor: G, Cohen, R, Feder-Elituv, J, Iazetta, P, Bunting, H, Mallidi, J, Bozinovski, C, Deemar, G T, Christakis, E A, Cohen, B I, Wong, R D, McLean, M, Myers, C D, Morgan, C D, Mazer, T S, Smith, B S, Goldman, C D, Naylor, S E, Fremes

Publikováno v: Circulation. 98

Laboratory evidence supports the use of adenosine-supplemented cardioplegia. An initial phase 1 dose-ranging clinical evaluation demonstrated that an adenosine concentration of 15 mumol/L could be safely administered with warm blood cardioplegia and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6e0123f5a53e9bf4ec9cb65216d4aa80
https://pubmed.ncbi.nlm.nih.gov/9852907

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Phase 1 human trial of adenosine-potassium cardioplegia

Autor: S E, Fremes, S L, Levy, G T, Christakis, S E, Walker, J, Iazetta, H R, Mallidi, R, Feder-Elituv, K A, Deemar, E A, Cohen, B I, Wong, B S, Goldman

Publikováno v: Circulation. 94

The cardioprotective role of adenosine in various models of ischemia-reperfusion, including adenosine supplementation to cardioplegic formulations, has been studied extensively. The appropriate dose of adenosine in humans is uncertain and could be li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::45a2d9b840a394989f6c2f3eefdc1077
https://pubmed.ncbi.nlm.nih.gov/8901777

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Cardiopulmonary bypass, temperature, and central nervous system dysfunction

Autor: R F, McLean, B I, Wong, C D, Naylor, W G, Snow, E M, Harrington, M, Gawel, S E, Fremes

Publikováno v: Circulation. 90(5 Pt 2)

Neurological injury is an important cause of morbidity and mortality after cardiac surgery. With the advent of warm heart surgery, the neuroprotective role of hypothermic cardiopulmonary bypass (CPB) has come under increasing scrutiny. Preliminary wo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ddb92061dbdab165fe97c8e949ecc141
https://pubmed.ncbi.nlm.nih.gov/7955261

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