Zobrazeno 1 - 10
of 20
pro vyhledávání: '"B I, Gerwin"'
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 259:L262-L269
Normal human bronchial epithelial (NHBE) cells respond to signals initiated by the binding of transforming growth factor-beta type 1 (TGF-beta 1) to its surface receptors by activating pathways that result in terminal squamous differentiation. By use
Publikováno v:
Cancer research. 60(14)
Accumulating data demonstrate overexpression of both inducible NO synthase (NOS2) and cyclooxygenase-2 (COX2) in many epithelial neoplasias. In addition, cyclooxygenase inhibitors have been shown to have antineoplastic and prophylactic efficacy again
Publikováno v:
International journal of cancer. 83(4)
Overexpression of the growth factor receptor ErbB-2/Her2/Neu has been implicated in the development of non-small-cell lung cancer. We have reported that the transformation of human lung epithelial cells by c-erbB-2 also requires an active ErbB-1 (EGF
Publikováno v:
Cellularmolecular biology research. 40(4)
Malignant transformation is frequently accompanied by obvious changes in cytoarchitecture, but the importance of these changes has been difficult to assess in view of the large number of other cellular changes that also occur. In this study, we trans
Publikováno v:
Cancer research. 53(9)
In order to examine the effects of the overexpression of c-erbB-2 (HER-2, neu) on human bronchial epithelial cells, a human c-erbB-2 expression vector was introduced into the simian virus 40 large T-antigen-immortalized human bronchial epithelial cel
Autor:
R R, Reddel, S E, Salghetti, J C, Willey, Y, Ohnuki, Y, Ke, B I, Gerwin, J F, Lechner, C C, Harris
Publikováno v:
Cancer research. 53(5)
Of five SV40-transformed clonal human bronchial epithelial cell lines previously shown to be nontumorigenic at early passages (R. R. Reddel et al., Cancer Res., 48: 1904-1909, 1988), two lines (BES-1A1 and BEAS-2B) from different donors have become w
Autor:
R A, Metcalf, J A, Welsh, W P, Bennett, M B, Seddon, T A, Lehman, K, Pelin, K, Linnainmaa, L, Tammilehto, K, Mattson, B I, Gerwin
Publikováno v:
Cancer research. 52(9)
Twenty cell lines from 17 individuals with malignant mesothelioma have been examined for p53 alterations by direct sequencing of genomic DNA, by evaluation of mRNA expression levels, and by immunocytochemical analysis of p53 protein expression in com
Publikováno v:
Cancer research. 50(7)
The relation between cellular phenotype and expression of chromosomal high mobility group proteins 14 and 17 (HMG-14 and HMG-17) has been examined in human cell lineages. Quantitation of HMG-14 and HMG-17 mRNA in several human cell lines revealed dif
Autor:
B I Gerwin
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 11:507-508
Publikováno v:
Virology. 56(1)