Zobrazeno 1 - 10
of 115
pro vyhledávání: '"B Herrington"'
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 7, p e1012302 (2024)
Protein kinase function and interactions with drugs are controlled in part by the movement of the DFG and ɑC-Helix motifs that are related to the catalytic activity of the kinase. Small molecule ligands elicit therapeutic effects with distinct selec
Externí odkaz:
https://doaj.org/article/0cb357eb62534ecb8b6babdcb88ff44f
Autor:
Forum Kayastha, Noah B. Herrington, Bandish Kapadia, Anirban Roychowdhury, Nahid Nanaji, Glen E. Kellogg, Ronald B. Gartenhaus
Publikováno v:
Molecular Medicine, Vol 28, Iss 1, Pp 1-18 (2022)
Abstract Background Deregulated translation initiation is implicated extensively in cancer initiation and progression. It is actively pursued as a viable target that circumvents the dependency on oncogenic signaling, a significant factor in current s
Externí odkaz:
https://doaj.org/article/bb12c8386e4c491e9979d7a0e964c2d5
Autor:
Mohammed H. AL Mughram, Claudio Catalano, Noah B. Herrington, Martin K. Safo, Glen E. Kellogg
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
The aliphatic hydrophobic amino acid residues—alanine, isoleucine, leucine, proline and valine—are among the most common found in proteins. Their structural role in proteins is seemingly obvious: engage in hydrophobic interactions to stabilize se
Externí odkaz:
https://doaj.org/article/f2ff01d0b7c34a5fa6fa2a27bb25f10f
Autor:
Cristine Smoczer, Yun K. Park, James B. Herrington, Mazin A. Askar, Sarah Plecha, Eric Krukonis, Susan B. Paurazas
Publikováno v:
Dentistry Journal, Vol 11, Iss 12, p 270 (2023)
Intracanal medicaments with maximal antimicrobial efficacy and minimal damage to resident stem cells are essential for successful regenerative endodontic procedures. 2-Hydroxyisocaproic acid (HICA) could have the attributes of a potential intracanal
Externí odkaz:
https://doaj.org/article/e7123f90703a452581ecb9cec3467e70
Autor:
Noah B. Herrington, Glen E. Kellogg
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Aspartic acid, glutamic acid and histidine are ionizable residues occupying various protein environments and perform many different functions in structures. Their roles are tied to their acid/base equilibria, solvent exposure, and backbone conformati
Externí odkaz:
https://doaj.org/article/661eb5cfa9c04bbf95a0feaa5eb06e6c
Publikováno v:
Journal of Structural Biology: X, Vol 5, Iss , Pp 100055- (2021)
Knowledge of three-dimensional protein structure is integral to most modern drug discovery efforts. Recent advancements have highlighted new techniques for 3D protein structure determination and, where structural data cannot be collected experimental
Externí odkaz:
https://doaj.org/article/5aa080215e094a3ea3907a6adbe898f8
Akademický článek
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Abstract LB023: Discovery, development and characterization of potent and selective USP11 inhibitors
Autor:
Forum Kayastha, Bandish Kapadia, Noah B. Herrington, Anirban Roychowdhury, Glen E. Kellogg, Ronald B. Gartenhaus
Publikováno v:
Cancer Research. 83:LB023-LB023
Ubiquitin-mediated events are emerging as the gatekeeper in cell proliferation, and the recognition of deubiquitinating enzymes (DUBs) as the critical regulators of these processes is rapidly growing. Several studies in the last decade confirmed that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::537bd27f539ff4851cc80d2da7d31d1f
https://doi.org/10.1158/1538-7445.am2023-lb023
https://doi.org/10.1158/1538-7445.am2023-lb023
Akademický článek
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Akademický článek
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