Zobrazeno 1 - 10
of 721
pro vyhledávání: '"B Haase"'
Autor:
Gregory W. Goldberg, Manjunatha Kogenaru, Sarah Keegan, Max A. B. Haase, Larisa Kagermazova, Mauricio A. Arias, Kenenna Onyebeke, Samantha Adams, Daniel K. Beyer, David Fenyö, Marcus B. Noyes, Jef D. Boeke
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract DNA targeting Class 2 CRISPR-Cas effector nucleases, including the well-studied Cas9 proteins, evolved protospacer-adjacent motif (PAM) and guide RNA interactions that sequentially license their binding and cleavage activities at protospacer
Externí odkaz:
https://doaj.org/article/3bdeec378a054518868d5fd4d1eac2b8
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Flow cytometry is a useful and efficient method for the rapid characterization of a cell population based on the optical and fluorescence properties of individual cells. Ideally, the cell population would consist of only healthy viable cells
Externí odkaz:
https://doaj.org/article/c2f1f5baa9d342979c554d6780ea9360
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract A major challenge in biotechnology and biomanufacturing is the identification of a set of biomarkers for perturbations and metabolites of interest. Here, we develop a data-driven, transcriptome-wide approach to rank perturbation-inducible ge
Externí odkaz:
https://doaj.org/article/1c27eb1e2c054300a287025a1e243747
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/c067da6488814f22a7fe9426e6d8f8a5
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Congenital sensorineural deafness (CSD) has been reported to affect up to 30% of Dalmatian dogs world-wide and while unilaterally deaf dogs can live a close to normal life, dogs suffering bilateral deafness are frequently euthanized. Extreme
Externí odkaz:
https://doaj.org/article/74a6b8601c5c49f9a683aea301be28a3
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-20 (2022)
Abstract Background Cell and circadian cycles control a large fraction of cell and organismal physiology by regulating large periodic transcriptional programs that encompass anywhere from 15 to 80% of the genome despite performing distinct functions.
Externí odkaz:
https://doaj.org/article/0f55cfa96ce9411ebaf32eda110b0971
Autor:
Breschine Cummins, Francis C Motta, Robert C Moseley, Anastasia Deckard, Sophia Campione, Marcio Gameiro, Tomáš Gedeon, Konstantin Mischaikow, Steven B Haase
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 10, p e1010145 (2022)
Large programs of dynamic gene expression, like cell cyles and circadian rhythms, are controlled by a relatively small "core" network of transcription factors and post-translational modifiers, working in concerted mutual regulation. Recent work sugge
Externí odkaz:
https://doaj.org/article/55e1e7261831478a89eda5fc425d2f41
Autor:
Adam B. Cobb, Eric B. Duell, Kaitlin B. Haase, R. Michael Miller, Yanqi Q. Wu, Gail W. T. Wilson
Publikováno v:
Plants, People, Planet, Vol 3, Iss 5, Pp 578-587 (2021)
Societal Impact Statement Agriculture touches all aspects of society and global environmental health. Dwindling phosphorous reserves are a looming crisis for civilization, and soil erosion typically far outpaces pedogenesis. Improving plant–mycorrh
Externí odkaz:
https://doaj.org/article/f30d391a7ddc433c8c47e55f3e44a8c3
Autor:
Joseph W. Saelens, Jens E. V. Petersen, Elizabeth Freedman, Robert C. Moseley, Drissa Konaté, Seidina A. S. Diakité, Karim Traoré, Natalie Vance, Rick M. Fairhurst, Mahamadou Diakité, Steven B. Haase, Steve M. Taylor
Publikováno v:
mSphere, Vol 6, Iss 5 (2021)
Sickle-trait hemoglobin (HbAS) confers nearly complete protection from severe, life-threatening malaria, yet the molecular mechanisms that underlie HbAS protection from severe malaria remain incompletely understood. Here, we used transcriptome sequen
Externí odkaz:
https://doaj.org/article/5f477ea7cd1147b6b6df7e4886dd328f
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 8, Pp 2699-2707 (2019)
Here we report a new plasmid shuffle vector for forcing budding yeast (Saccharomyces cerevisiae) to incorporate a new genetic pathway in place of a native pathway – even an essential one – while maintaining low false positive rates (less than 1 i
Externí odkaz:
https://doaj.org/article/4e364f0361504ea7a8085eb7a7bd0511