Zobrazeno 1 - 10
of 15
pro vyhledávání: '"B H, Dvorchik"'
Autor:
B H, Dvorchik
Publikováno v:
Current opinion in molecular therapeutics. 2(3)
Antisense oligonucleotides hold great promise as novel therapeutic agents designed to specifically and selectively inhibit the production of various disease-related gene products. For efficacy to occur, the therapeutic entity must reach the site of a
Autor:
B H, Dvorchik, J K, Marquis
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(10)
The ocular disposition and toxicity of GEM132, a mixed backbone phosphorothioate oligonucleotide developed for the treatment of cytomegalovirus-induced retinitis, were studied in rabbits for 6 months following single intravitreal injection of 5, 20,
Publikováno v:
The Journal of Clinical Pharmacology. 28:216-221
Antipyrine pharmacokinetics as well as estradiol and progesterone concentrations were measured in plasma of 11 healthy pregnant women during the first two trimesters and again in the same patients 6 to 20 weeks after interruption of pregnancy. During
Autor:
B. H. Dvorchik, Moses J. Namkung, Curtis J. Omiecinski, S. T. Chao, Sidney D. Nelson, Mont R. Juchau
Publikováno v:
Developmental Pharmacology and Therapeutics. 2:1-16
Placental and fetal tissues obtained from humans, monkeys, rats and rabbits contained monooxygenases capable of catalyzing the formation of catechol estrogens. Treatments of pregnant rats with phenobarbital, Aroclor 1254, or 3-methylcholanthrene each
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 4(5)
The kinetics of the N-demethylation of benzphetamine, ethylmorphine, meperidine, and methadone have been studied in microsomes isolated from livers of the fetal stumptailed macaque (Macaca arctoides) during the last third of gestation. The apparent K
Autor:
B H, Dvorchik
Publikováno v:
International journal of biological research in pregnancy. 3(3)
This review examines the literature on drug disposition during human pregnancy. Drugs are considered on the basis of their mode of excretion and hepatic extraction ratio in order to assess the general effects of pregnancy on drug disposition. Pregnan
Autor:
B H, Dvorchik, E S, Vesell
Publikováno v:
Clinical chemistry. 22(6)
We review some pharmacokinetic principles that can facilitate interpretation of data obtained during therapeutic drug monitoring: the one- and two-compartment models, volume of drug distribution, drug clearance, organ clearance, bioavailability, firs
Publikováno v:
Developmental pharmacology and therapeutics. 2(1)
Placental and fetal tissues obtained from humans, monkeys, rats and rabbits contained monooxygenases capable of catalyzing the formation of catechol estrogens. Treatments of pregnant rats with phenobarbital, Aroclor 1254, or 3-methylcholanthrene each
Publikováno v:
Laboratory animal science. 33(1)
The purpose of this study was to determine if environmental ammonia is absorbed through the lungs of rats into the blood and, in turn, exerts an effect on blood pH, blood gases, and hepatic drug metabolizing enzyme activity. In phase 1 of the study,
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 208(2)