Zobrazeno 1 - 6
of 6
pro vyhledávání: '"B G, Utterback"'
Publikováno v:
Receptor. 3(4)
Arg-Gly-Asp-Ser (RGDS) 1, Arg-Val-Asp-Ser (RVDS) 2, Arg-dVal-Asp-Ser (R[d]VDS) 3, and a cyclic RGD peptide, cyclo S,R [H-Pen-Arg-Gly-Asp-Pen-Gly-OH] 4, were tested for their ability to antagonize GPIIb-IIIa function. The activities were found to fall
Autor:
G P, Dubé, D E, Mais, J A, Jakubowski, K A, Brune, B G, Utterback, T A, True, L E, Rinkema, W L, Kurtz
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 262(2)
The stereoisomers of S-145, a novel thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor ligand, were compared to TXA2/PGH2 receptor antagonists, SQ29548 and BM13505 in guinea pig platelets, aortas and trachea. Equilibrium binding assays in platelets
Autor:
C V, Jackson, V G, Crowe, J D, Frank, H C, Wilson, W J, Coffman, B G, Utterback, J A, Jakubowski, G F, Smith
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 261(2)
The antithrombotic activity of the tripeptide thrombin inhibitor, D-methyl-phenylalanyl-prolyl-arginal (GYKI-14766), was compared to heparin in a model of canine coronary artery thrombosis. Thrombogenesis was initiated by electrolytic injury of the i
Publikováno v:
Molecular pharmacology. 30(6)
LY195115 selectively inhibited the peak III isozyme of cardiac cyclic nucleotide phosphodiesterase (PDE) eluted from DEAE-cellulose columns. Inhibition curves were biphasic, suggesting heterogeneity within this preparation. Since peak III PDE is repo
Autor:
D R, Holland, J H, Wikel, R F, Kauffman, J K, Smallwood, K M, Zimmerman, B G, Utterback, J A, Turk, M I, Steinberg
Publikováno v:
Journal of cardiovascular pharmacology. 14(3)
Compound LY249933 and its component diastereomers, (RR) and (SR), were studied for their vascular and cardiac effects in vitro and in vivo. In guinea pig cardiac ventricular membranes, LY249933, (RR), and (SR) potently displaced bound [3H]nitrendipin
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 242(3)
Several novel cardiotonic vasodilators including bipyridines (amrinone and milrinone), imidazolones (enoximone and piroximone), dihydropyridazinones (Cl-914, Cl-930 and LY195115) and an imidazopyridine (isomazole) relaxed rat aortic strips contracted