Výsledky vyhledávání - "B G, Rumberger"

Rapid decline in folylpolyglutamate synthetase activity and gene expression during maturation of HL-60 cells. Nature of the effect, impact on folate compound polyglutamate pools, and evidence for programmed down-regulation during maturation

Autor: M G, Egan, S, Sirlin, B G, Rumberger, T A, Garrow, B, Shane, F M, Sirotnak

Publikováno v: The Journal of biological chemistry. 270(10)

These studies in HL-60 cells examined the regulation of folylpolyglutamate synthetase (FPGS) activity at the level of gene expression during terminal maturation. Following addition of 210 mM Me2SO to cultures of HL-60 cells at a concentration that in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e9e32cb451e03686feeabfd3a57adb1c
https://pubmed.ncbi.nlm.nih.gov/7890662

Zobrazit plný text záznamu

Biological determination of selective antitumor action of 4-amino-folate analogs

Autor: J.R. Barrueco, B. G. Rumberger, Frank Sirotnak

Publikováno v: Zurich, Switzerland, September 3–8, 1989

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb7bcdd8737c8d56cb84f44eb768214a
https://doi.org/10.1515/9783110889000-226

Zobrazit plný text záznamu

Differing specificities for 4-aminofolate analogues of folylpolyglutamyl synthetase from tumors and proliferative intestinal epithelium of the mouse with significance for selective antitumor action

Autor: B G, Rumberger, J R, Barrueco, F M, Sirotnak

Publikováno v: Cancer research. 50(15)

Folylpolyglutamyl synthetase (FPGS), partially purified from murine L1210 leukemia and Sarcoma 180 cells and the proliferative fraction of luminal epithelium from mouse small intestine (the site of limiting toxicity to folate analogues), was examined

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1eff1ac8adb01f0aaca2f95730242ac7
https://pubmed.ncbi.nlm.nih.gov/2369741

Zobrazit plný text záznamu

Preferential selection during therapy in vivo by edatrexate compared to methotrexate of resistant L1210 cell variants with decreased folylpolyglutamate synthetase activity

Autor: B G, Rumberger, F A, Schmid, G M, Otter, F M, Sirotnak

Publikováno v: Cancer communications. 2(9)

Acquired resistance of the L1210 leukemia in mice developed with less rapidity during therapy with edatrexate (10-ethyl-10-deazaaminopterin, EDX) than with MTX. Since this was explained only partially by the somewhat greater antitumor activity of EDX

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e96b341513041feb21de4cfe9f84cdc8
https://pubmed.ncbi.nlm.nih.gov/2206778

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání