Zobrazeno 1 - 10
of 46
pro vyhledávání: '"B G, Lake"'
Publikováno v:
Alternatives to laboratory animals : ATLA. 26(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::361c29f51250106f3ee4164684aef79d
https://pubmed.ncbi.nlm.nih.gov/26042435
https://pubmed.ncbi.nlm.nih.gov/26042435
Publikováno v:
Xenobiotica. 33:691-702
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40238d1dca75d1894e2e4fe96b7908db
https://doi.org/10.1080/0049825031000108306
https://doi.org/10.1080/0049825031000108306
Publikováno v:
Journal of Mass Spectrometry. 33:1237-1245
Olanzapine metabolism was investigated using incubation of olanzapine with human liver slices. The intent of the investigation was to identify olanzapine metabolites and determine if the human liver slice incubations could potentially produce quantit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dbaab9edaa89a7a39ef3cbb7b0d62a8
https://doi.org/10.1002/(sici)1096-9888(199812)33:12<1237::aid-jms742>3.0.co
https://doi.org/10.1002/(sici)1096-9888(199812)33:12<1237::aid-jms742>3.0.co
Autor:
B G Lake
Publikováno v:
Annual Review of Pharmacology and Toxicology. 35:483-507
A wide variety of chemicals have been shown to produce liver enlargement, peroxisome proliferation, and induction of peroxisomal and microsomal fatty acid-oxidizing enzyme activities in rats and mice. Moreover, certain peroxisome proliferators have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0abfa1543aa004cbf62ee6ec1766abc
https://doi.org/10.1146/annurev.pa.35.040195.002411
https://doi.org/10.1146/annurev.pa.35.040195.002411
Molecular modelling of members of the P4502A subfamily: application to studies of enzyme specificity
Autor:
David F.V. Lewis, B. G. Lake
Publikováno v:
Xenobiotica. 25:585-598
1. Using the recently published crystal structure of a bacterial P450, namely 102 (also termed P450bm3), as a template molecular models of mammalian 2A1, 2A4, 2A5 and 2A6 were constructed. 2. Substrate interaction studies demonstrated that in keeping
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47211d0065f78ded659e543fbf5d054f
https://doi.org/10.3109/00498259509061877
https://doi.org/10.3109/00498259509061877
Publikováno v:
Drug Metabolism Reviews. 26:261-285
(1994). Molecular Modeling of Enzymes and Receptors Involved in Carcinogenesis: Qsars and Compacted-3D. Drug Metabolism Reviews: Vol. 26, No. 1-2, pp. 261-285.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b97b2a38cb7d4d29f0f6a54f5d86b75c
https://doi.org/10.3109/03602539409029797
https://doi.org/10.3109/03602539409029797
Autor:
David F.V. Lewis, B. G. Lake
Publikováno v:
Xenobiotica. 23:79-96
1. The three-dimensional structure of a portion of the ligand-binding domain of the mouse liver peroxisome proliferator-activated receptor (PPAR) described by Issemann and Green (1990) has been modelled from amino acid sequence data. 2. By inspection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73145638dbb06efac491a99aa191e497
https://doi.org/10.3109/00498259309059364
https://doi.org/10.3109/00498259309059364
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 29(5)
1. The biotransformation of [3H]clenbuterol, [3H]salbutamol, [14C]salmeterol and 7-ethoxycoumarin by bovine liver was investigated by incubation with freshly prepared microsomes, suspension and monolayer cultures of isolated hepatocytes, precision-cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034a411db8410382012774b07e8a5997
https://pubmed.ncbi.nlm.nih.gov/10379986
https://pubmed.ncbi.nlm.nih.gov/10379986
Publikováno v:
Pharmacogenetics. 9(2)
The metabolism of 50 microM [3-14C] coumarin to polar products separated by high performance liquid chromatography (HPLC) and covalently bound metabolites in liver microsomes was compared in a series of inbred strains of mice. Coumarin metabolism to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1608d5d61b93a815a162fe3a971657e2
https://pubmed.ncbi.nlm.nih.gov/10376771
https://pubmed.ncbi.nlm.nih.gov/10376771
Publikováno v:
Teratogenesis, carcinogenesis, and mutagenesis. 19(2)
An immunoslot blotting (ISB) method for quantitating aflatoxin B1-DNA adduct levels has been developed and used to examine the relationship between dose and hepatic aflatoxin B1-DNA adduct levels in rats fed aflatoxin B1 (AFB1) in the diet at dose le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::296c709f47375137b4d138767eb012ac
https://pubmed.ncbi.nlm.nih.gov/10332812
https://pubmed.ncbi.nlm.nih.gov/10332812