Separating the direct effects of risk factors for atherosclerotic cardiovascular disease from those mediated by type 2 diabetes

Autor: Venexia M Walker, Alice R Carter, Miriam S. Udler, Neil M Davies, G Davey Smith, Tom R. Gaunt, B F Voight, Michael G. Levin, Scott M. Damrauer, Marijana Vujkovic

BackgroundType 2 diabetes and atherosclerotic cardiovascular disease share several risk factors. However, it is unclear whether the effect of these risk factors on liability to atherosclerotic cardiovascular disease is independent of their effect on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4b613f692c0ebbcbf982f8fd4d0adad9
https://doi.org/10.1101/2021.08.05.21261658

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

Autor: Rob M. van Dam, Francis S. Collins, Konstantin Strauch, Raimund Erbel, Rafn Benediktsson, Philippe Froguel, Kyle J. Gaulton, Peter Donnelly, Torben Hansen, Longda Jiang, Lennart C. Karssen, Rona J. Strawbridge, David J. Hunter, Leena Kinnunen, Thomas Meitinger, Michael Stumvoll, Stéphane Cauchi, Ching-Ti Liu, Olga McLeod, Oluf Pedersen, Michael Boehnke, Denis Rybin, Karl Gertow, Tõnu Esko, Bernhard O. Boehm, Sonali Pechlivanis, Bo Isomaa, Anne U. Jackson, Clement Ma, Yingchang Lu, Nicola D. Kerrison, Ruth J. F. Loos, Caroline S. Fox, Chiara Scapoli, Jian'an Luan, Martina Müller-Nurasyid, Domenico Palli, Anke Tönjes, Natalie R. van Zuydam, Neil Robertson, Barbara Thorand, Natalia Pervjakova, Andrew R. Wood, Karin Leander, Unnur Thorsteinsdottir, Sara M. Willems, Karen L. Mohlke, Robert A. Scott, Markus M. Nöthen, Ulf de Faire, Qi Sun, Eric Boerwinkle, Roman Wennauer, Douglas M. Ruderfer, Marika Kaakinen, Nigel W. Rayner, Jaakko Tuomilehto, Nisa M. Maruthur, Richard N. Bergman, Janina S. Ried, Himanshu Chheda, Josée Dupuis, Juan Tajes-Fernandes, Steve E. Humphries, Reedik Mägi, Gonçalo R. Abecasis, B F Voight, David Couper, Cornelia M. van Duijn, Samuli Ripatti, Yeji Lee, Heikki A. Koistinen, Christian Dina, Andres Metspalu, Lu Qi, James S. Pankow, Han Chen, Damiano Baldassarre, Mattias Frånberg, Gerald Steinbach, Inga Prokopenko, Matthias Blüher, Jose C. Florez, Julia Meyer, Niels Grarup, Anders Hamsten, Valeriya Lyssenko, James B. Meigs, Pritam Chanda, Leif Groop, Sarah Edkins, Anubha Mahajan, Gunnar Sigurðsson, Marilyn C. Cornelis, Christian Gieger, Nancy L. Pedersen, Andrew T. Hattersley, Paul W. Franks, Nicholas J. Wareham, Stefan Gustafsson, Katharine R. Owen, Peter Kovacs, Andrew D. Johnson, Lori L. Bonnycastle, Tiinamaija Tuomi, Aurelio Barricarte Gurrea, Tune H. Pers, Eric J.G. Sijbrands, Phoenix Kwan, Emmi Tikkanen, Elisabeth M. van Leeuwen, Stéphane Lobbens, Claudia Langenberg, E. Eury, Thomas W. Mühleisen, Lewin Eisele, Veikko Salomaa, Satu Mӓnnistö, Christian Fuchsberger, Evelin Mihailov, David Altshuler, Timothy M. Frayling, Peter Almgren, Harald Grallert, Hans A. Kestler, Beverley Balkau, Erik Ingelsson, Colin N. A. Palmer, Yvonne T. van der Schouw, Michael Roden, Thomas Sparsø, Karl-Heinz Jöckel, Johan G. Eriksson, Inês Barroso, John D. Eicher, Bengt Sennblad, Bruna Gigante, Andrew D. Morris, Panagiotis Deloukas, Man Li, Allan Linneberg, Astradur B. Hreidarsson, Lars Lannfelt, Elena Tremoli, Liming Liang, Omri Gottesman, Letizia Marullo, Peter S. Chines, Kari Stefansson, Mark I. McCarthy, Andrew P. Morris, Erwin P. Bottinger, Augustine Kong, Torben Jørgensen, Tanya M. Teslovich, Frank B. Hu, Dorothée Thuillier, Peter Kraft, Heiner Boeing, Laura J. Scott, Gudmar Thorleifsson, Lars Lind, John R. B. Perry, Heather M. Stringham, Susanne Moebus, Valgerdur Steinthorsdottir, Cecilia M. Lindgren, Guillaume Charpentier, Eleftheria Zeggini, Leena Peltonen, Loic Yengo, Norman Klopp, Teresa Ferreira, Christian Theil Have, Marit E. Jørgensen

Publikováno v: Scott, R A, Scott, L J, Mägi, R, Marullo, L, Gaulton, K J, Kaakinen, M, Pervjakova, N, Pers, T H, Johnson, A D, Eicher, J D, Jackson, A U, Ferreira, T, Lee, Y, Ma, C, Steinthorsdottir, V, Thorleifsson, G, Qi, L, Van Zuydam, N R, Mahajan, A, Chen, H, Almgren, P, Voight, B F, Grallert, H, Müller-Nurasyid, M, Ried, J S, Rayner, N W, Robertson, N R, Karssen, L C, van Leeuwen, E M, Willems, S M, Fuchsberger, C, Kwan, P, Teslovich, T M, Chanda, P, Li, M, Lu, Y, Dina, C, Thuillier, D, Yengo, L, Jiang, L, Sparso, T, Kestler, H A, Chheda, H, Eisele, L, Gustafsson, S, Frånberg, M, Strawbridge, R J, Benediktsson, R, Hreidarsson, A B, Jørgensen, T & DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium 2017, ' An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans ', Diabetes, vol. 66, no. 11, pp. 2888-2902 . https://doi.org/10.2337/db16-1253
Diabetes 66, 2888-2902 (2017)
Diabetes, 66(11), 2888-2902. American Diabetes Association Inc.
Scott, R A, Scott, L J, Mägi, R, Marullo, L, Gaulton, K J, Kaakinen, M, Pervjakova, N, Pers, T H, Johnson, A D, Eicher, J D, Jackson, A U, Ferreira, T, Lee, Y, Ma, C, Steinthorsdottir, V, Thorleifsson, G, Qi, L, Van Zuydam, N R, Mahajan, A, Chen, H, Almgren, P, Voight, B F, Grallert, H, Müller-nurasyid, M, Ried, J S, Rayner, W N, Robertson, N, Karssen, L C, Van Leeuwen, E M, Willems, S M, Fuchsberger, C, Kwan, P, Teslovich, T M, Chanda, P, Li, M, Lu, Y, Dina, C, Thuillier, D, Yengo, L, Jiang, L, Sparso, T, Kestler, H A, Chheda, H, Eisele, L, Gustafsson, S, Frånberg, M, Strawbridge, R J, Benediktsson, R, Hreidarsson, A B, Kong, A, Sigurðsson, G, Kerrison, N D, Luan, J, Liang, L, Meitinger, T, Roden, M, Thorand, B, Esko, T, Mihailov, E, Fox, C, Liu, C, Rybin, D, Isomaa, B, Lyssenko, V, Tuomi, T, Couper, D J, Pankow, J S, Grarup, N, Have, C T, Jørgensen, M E, Jørgensen, T, Linneberg, A, Cornelis, M C, Van Dam, R M, Hunter, D J, Kraft, P, Sun, Q, Edkins, S, Owen, K R, Perry, J R, Wood, A R, Zeggini, E, Tajes-fernandes, J, Abecasis, G R, Bonnycastle, L L, Chines, P S, Stringham, H M, Koistinen, H A, Kinnunen, L, Sennblad, B, Mühleisen, T W, Nöthen, M M, Pechlivanis, S, Baldassarre, D, Gertow, K, Humphries, S E, Tremoli, E, Klopp, N, Meyer, J, Steinbach, G, Wennauer, R, Eriksson, J G, Mӓnnistö, S, Peltonen, L, Tikkanen, E, Charpentier, G, Eury, E, Lobbens, S, Gigante, B, Leander, K, Mcleod, O, Bottinger, E P, Gottesman, O, Ruderfer, D, Blüher, M, Kovacs, P, Tonjes, A, Maruthur, N M, Scapoli, C, Erbel, R, Jöckel, K, Moebus, S, De Faire, U, Hamsten, A, Stumvoll, M, Deloukas, P, Donnelly, P J, Frayling, T M, Hattersley, A T, Ripatti, S, Salomaa, V, Pedersen, N L, Boehm, B O, Bergman, R N, Collins, F S, Mohlke, K L, Tuomilehto, J, Hansen, T, Pedersen, O, Barroso, I, Lannfelt, L, Ingelsson, E, Lind, L, Lindgren, C M, Cauchi, S, Froguel, P, Loos, R J, Balkau, B, Boeing, H, Franks, P W, Gurrea, A B, Palli, D, Van Der Schouw, Y T, Altshuler, D, Groop, L C, Langenberg, C, Wareham, N J, Sijbrands, E, Van Duijn, C M, Florez, J C, Meigs, J B, Boerwinkle, E, Gieger, C, Strauch, K, Metspalu, A, Morris, A D, Palmer, C N, Hu, F B, Thorsteinsdottir, U, Stefansson, K, Dupuis, J, Morris, A P, Boehnke, M, Mccarthy, M I & Prokopenko, I 2017, ' An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans ', Diabetes, pp. db161253 . https://doi.org/10.2337/db16-1253
Scott, R A, Scott, L J, Mägi, R, Marullo, L, Gaulton, K J, Kaakinen, M, Pervjakova, N, Pers, T H, Johnson, A D, Eicher, J D, Jackson, A U, Ferreira, T, Lee, Y, Ma, C, Steinthorsdottir, V, Thorleifsson, G, Qi, L, Van Zuydam, N R, Mahajan, A, Chen, H, Almgren, P, Voight, B F, Grallert, H, Müller-Nurasyid, M, Ried, J S, Rayner, N W, Robertson, N, Karssen, L C, van Leeuwen, E M, Willems, S M, Fuchsberger, C, Kwan, P, Teslovich, T M, Chanda, P, Li, M, Lu, Y, Dina, C, Thuillier, D, Yengo, L, Jiang, L, Sparso, T, Kestler, H A, Chheda, H, Eisele, L, Gustafsson, S, Frånberg, M, Strawbridge, R J, Benediktsson, R, Jørgensen, M E, Hansen, T & DIAGRAM Consortium 2017, ' An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans ', Diabetes, vol. 66, no. 11, pp. 2888-2902 . https://doi.org/10.2337/db16-1253
Diabetes
Diabetes, 66(11), 2888. American Diabetes Association Inc.
DIABETES

To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D case and 132,532 control subjects of European ancestry after imputation usin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43a331d53d3a1bc806c1e9fb787f732
https://vbn.aau.dk/da/publications/bc27dd82-ce45-4e74-a934-5ef0ac509e8e