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Agonists at the δ-opioid receptor modify the binding of µ-receptor agonists to the µ-δ receptor hetero-oligomer

Autor: N, Kabli, N, Martin, T, Fan, T, Nguyen, A, Hasbi, G, Balboni, B F, O'Dowd, S R, George

Publikováno v: British journal of pharmacology. 161(5)

µ- and δ-opioid receptors form heteromeric complexes with unique ligand binding and G protein-coupling profiles linked to G protein α z-subunit (Gα(z) ) activation. However, the mechanism of action of agonists and their regulation of the µ-δ re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bbe8dfc2e7349c6d9ee6b00e3a42b611
https://pubmed.ncbi.nlm.nih.gov/20977461

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A mutation of the beta 2-adrenergic receptor impairs agonist activation of adenylyl cyclase without affecting high affinity agonist binding. Distinct molecular determinants of the receptor are involved in physical coupling to and functional activation of Gs

Autor: Marc G. Caron, M Hnatowich, B F O'Dowd, William P. Hausdorff, Robert J. Lefkowitz

Publikováno v: Journal of Biological Chemistry. 265:1388-1393

Activation of guanyl nucleotide regulatory proteins (G proteins) by hormones and neurotransmitters appears to require the formation of high affinity agonist-receptor-G protein ternary complexes. In the case of the beta 2-adrenergic receptor, multiple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee5939fdf4008415b5ce56c2797f3dee
https://doi.org/10.1016/s0021-9258(19)40026-4

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Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties

Autor: S R, George, T, Fan, Z, Xie, R, Tse, V, Tam, G, Varghese, B F, O'Dowd

Publikováno v: The Journal of biological chemistry. 275(34)

The existence of dimers and oligomers for many G protein-coupled receptors has been described by us and others. Since many G protein-coupled receptor subtypes are highly homologous to each other, we examined whether closely related receptors may inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0c6df5b653e33eb01f8465ec579da1a4
https://pubmed.ncbi.nlm.nih.gov/10842167

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Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate

Autor: D S, Im, C E, Heise, M A, Harding, S R, George, B F, O'Dowd, D, Theodorescu, K R, Lynch

Publikováno v: Molecular pharmacology. 57(4)

Two G protein-coupled receptors (Edg-2) and (Edg-4) for the lysolipid phosphoric acid mediator lysophosphatidic acid have been described by molecular cloning. However, the calcium-mobilizing receptor Edg-4 is not expressed in some cell lines that exh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3b11d00929fd138ffd3627ea2f98c3ae
https://pubmed.ncbi.nlm.nih.gov/10727522

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Heterogeneity of renin alleles in outbred Dahl salt-sensitive (Brookhaven) rats

Autor: B F O'Dowd, J P Rapp

Publikováno v: Hypertension. 18:9-11

Selectively outbred Dahl salt-sensitive (DS) and salt-resistant (DR) rats were compared with the inbred Dahl salt-sensitive (SS/Jr) and salt-resistant (SR/Jr) rats developed from the original Brookhaven stocks by J.P. Rapp. The animals were evaluated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72df041418677ea44be7dcfe0d770d15
https://doi.org/10.1161/01.hyp.18.1.9

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Agonist-induced, G protein-dependent and -independent down-regulation of the mu opioid receptor. The receptor is a direct substrate for protein-tyrosine kinase

Autor: Y, Pak, B F, O'Dowd, J B, Wang, S R, George

Publikováno v: The Journal of biological chemistry. 274(39)

The mu opioid receptor (MOR) has been shown to desensitize after 1 h of exposure to the opioid peptide, [D-Ala(2), N-MePhe(4), Gly-ol(5)]enkephalin (DAMGO), largely by the loss of receptors from the cell surface and receptor down-regulation. We have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ece87fac18e4b5d7a879ccbe2a59c0bb
https://pubmed.ncbi.nlm.nih.gov/10488100

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Mutation screening of the dopamine D1 receptor gene in Tourette's syndrome and alcohol dependent patients

Autor: M, Thompson, D E, Comings, L, Feder, S R, George, B F, O'Dowd

Publikováno v: American journal of medical genetics. 81(3)

We report a single stranded conformational polymorphism (SSCP) analysis of the coding region of the dopamine D1 receptor (DRD1) in Tourette's syndrome (n = 50) and control (n = 50) subjects. Tourette's syndrome populations with comorbidity for attent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4ec7368d0db55b50a7337a15dfe09ca1
https://pubmed.ncbi.nlm.nih.gov/9603612

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