Zobrazeno 1 - 10
of 286
pro vyhledávání: '"B F, O'Dowd"'
Autor:
B. F. O'Dowd
Publikováno v:
Molecular Endocrinology. 14:183-193
Publikováno v:
Al-Anbar Medical Journal. Jun2024, Vol. 20 Issue 1, p10-18. 9p.
Publikováno v:
British journal of pharmacology. 161(5)
µ- and δ-opioid receptors form heteromeric complexes with unique ligand binding and G protein-coupling profiles linked to G protein α z-subunit (Gα(z) ) activation. However, the mechanism of action of agonists and their regulation of the µ-δ re
Publikováno v:
Journal of Biological Chemistry. 265:1388-1393
Activation of guanyl nucleotide regulatory proteins (G proteins) by hormones and neurotransmitters appears to require the formation of high affinity agonist-receptor-G protein ternary complexes. In the case of the beta 2-adrenergic receptor, multiple
Publikováno v:
The Journal of biological chemistry. 275(34)
The existence of dimers and oligomers for many G protein-coupled receptors has been described by us and others. Since many G protein-coupled receptor subtypes are highly homologous to each other, we examined whether closely related receptors may inte
Publikováno v:
Molecular pharmacology. 57(4)
Two G protein-coupled receptors (Edg-2) and (Edg-4) for the lysolipid phosphoric acid mediator lysophosphatidic acid have been described by molecular cloning. However, the calcium-mobilizing receptor Edg-4 is not expressed in some cell lines that exh
Autor:
B F O'Dowd, J P Rapp
Publikováno v:
Hypertension. 18:9-11
Selectively outbred Dahl salt-sensitive (DS) and salt-resistant (DR) rats were compared with the inbred Dahl salt-sensitive (SS/Jr) and salt-resistant (SR/Jr) rats developed from the original Brookhaven stocks by J.P. Rapp. The animals were evaluated
Publikováno v:
The Journal of biological chemistry. 274(39)
The mu opioid receptor (MOR) has been shown to desensitize after 1 h of exposure to the opioid peptide, [D-Ala(2), N-MePhe(4), Gly-ol(5)]enkephalin (DAMGO), largely by the loss of receptors from the cell surface and receptor down-regulation. We have
Publikováno v:
American journal of medical genetics. 81(3)
We report a single stranded conformational polymorphism (SSCP) analysis of the coding region of the dopamine D1 receptor (DRD1) in Tourette's syndrome (n = 50) and control (n = 50) subjects. Tourette's syndrome populations with comorbidity for attent
Publikováno v:
Endocrinology. 138(10)
Dopamine D2 receptor agonists are commonly used in the control of PRL-secreting adenomas, and the sensitivity of dopamine agonists during long term therapy is exquisite. However, the molecular mechanisms responsible for the maintenance of this cellul