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pro vyhledávání: '"B F, Hales"'
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 74:565-571
Publikováno v:
Biology of reproduction. 65(1)
During germ cell development different spermatogenic cell types show remarkable variation in their susceptibility to stressful stimuli. Various cellular mechanisms are triggered in germ cells after exposure to stress, but the expression of only a few
Publikováno v:
Biology of reproduction. 63(1)
Paternal exposure to chronic low doses of cyclophosphamide, an anticancer agent, results in aberrant embryonic development of the progeny. We hypothesized that paternal exposure to cyclophosphamide disturbs zygotic gene activity regulating proper pro
Publikováno v:
Biology of reproduction. 56(6)
Treatment with cyclophosphamide, a commonly used anticancer drug, may result in oligozoospermia or azoospermia. The objective of this study was to determine whether exposure of male rats to cyclophosphamide induces apoptosis in male germ cells, and i
Autor:
T R, Ozolins, B F, Hales
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 280(2)
The transcription factor activator protein-1 (AP-1), composed of the Fos and Jun families of proto-oncogenes, is induced in response to extracellular signals as part of an immediate-early gene response. We hypothesize that teratogens such as oxidativ
Autor:
S, Adel Moallem, B F, Hales
Publikováno v:
Biology of reproduction. 55(2)
Apoptotic cell death is important in pattern formation in the limb. The purpose of this study was to investigate the relationship between the occurrence of apoptosis in the mouse limb during normal and abnormal development as well as the expression o
Publikováno v:
Canadian journal of physiology and pharmacology. 74(5)
An international symposium entitled Chemical Carcinogenesis, Mutagenesis and Teratogenesis: a Tribute to James and Elizabeth Miller was held in Toronto, Ont., July 19, 1994. This symposium theme was discussed in the presence of James Miller, 79 years
Publikováno v:
Biology of reproduction. 53(6)
Treatment of male rats with low dosages of cyclophosphamide causes a dramatic increase in early embryo death among their progeny without significantly affecting the general health of the male. It is hypothesized that cyclophosphamide exerts its effec
Autor:
B, Chen, B F, Hales
Publikováno v:
Biology of reproduction. 53(5)
The cadherins are a family of calcium-dependent cell adhesion molecules that are regulated both spatially and temporally during development. Epithelial cadherin (E-cadherin) is present in epithelial cells in both the embryo and yolk sac during organo
Publikováno v:
Biology of reproduction. 52(1)
Previous studies from our laboratory have shown that chronic exposure of the father to low doses of cyclophosphamide results in a significant increase in early embryonic death with little effect on the male reproductive system in rats. Such effects o