Zobrazeno 1 - 5
of 5
pro vyhledávání: '"B F, Drenth"'
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 18(6)
The metabolism of 2-(N-propyl-N-2-thienylethylamino)-5-hydroxytetralin (N-0437) was investigated in conscious monkeys after subsequent i.v., oral, and ocular administration. The administration of the drug caused some physiological effects, such as br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::26d752a8353a1bb7b6d555d2bf801d61
https://pubmed.ncbi.nlm.nih.gov/1981538
https://pubmed.ncbi.nlm.nih.gov/1981538
Publikováno v:
Pharmaceutical research. 7(6)
Upon application of 14C-labeled cyoctol to the forearm of healthy volunteers, no parent cyoctol was detectable in ipsilateral blood plasma. The 14C activity was largely accounted for by a component with higher lipophilicity than the parent compound,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1909d72353b22af9eed4cc74b9ae83b4
https://pubmed.ncbi.nlm.nih.gov/2367332
https://pubmed.ncbi.nlm.nih.gov/2367332
Publikováno v:
Pharmaceutical research. 7(5)
Chain-labeled 14C-Azone was intravenously administered to hamster, monkey, and rat, to compare its metabolic profile with that obtained previously in humans after dermal application. Azone-derived radioactivity was excreted predominantly in the urine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::383513d4100bf25199c9b421342b981e
https://pubmed.ncbi.nlm.nih.gov/2367317
https://pubmed.ncbi.nlm.nih.gov/2367317
Publikováno v:
Pharmaceutical research. 4(6)
The percutaneous absorption and elimination of Azone, a new penetration enhancer, were investigated in humans. The distribution and accumulation of Azone in the skin were studied by means of tape stripping. These studies reveal that pure Azone is poo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6f8518482c2d9c944af509e282960d5d
https://pubmed.ncbi.nlm.nih.gov/3508567
https://pubmed.ncbi.nlm.nih.gov/3508567
Autor:
B F, Drenth, R A, de Zeeuw
Publikováno v:
Journal of chromatography. 191
A systematic approach to the investigation of metabolic degradation of drugs is presented. Extraction of the biological sample is avoided by direct injection of bile or urine in a reversed-phase high-performance liquid chromatography system. Good sep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2b57a2cace99bea84285526d06c8252f
https://pubmed.ncbi.nlm.nih.gov/7380960
https://pubmed.ncbi.nlm.nih.gov/7380960