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Tonicity inversely modulates lipocalin-2 (Lcn2/24p3/NGAL) receptor (SLC22A17) and Lcn2 expression via Wnt/β-catenin signaling in renal inner medullary collecting duct cells: implications for cell fate and bacterial infection

Autor: R. Betten, B. Scharner, S. Probst, B. Edemir, N. A. Wolff, C. Langelueddecke, W.-K. Lee, F. Thévenod

Publikováno v: Cell Communication and Signaling, Vol 16, Iss 1, Pp 1-20 (2018)

Abstract Background We have previously evidenced apical expression of the 24p3/NGAL/lipocalin-2 receptor (Lcn2-R; SLC22A17) in inner medullary collecting duct (IMCD) cells, which are present in vivo in a hyperosmotic/-tonic environment that activates

Externí odkaz: https://doaj.org/article/204f88d4ac7d4db4a9f8aabe42d168c4

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Autor: Stephanie Probst, C. Langelueddecke, Frank Thévenod, Wing-Kee Lee, R. Betten, Bettina Scharner, B. Edemir, Natascha A. Wolff

Publikováno v: Cell Communication and Signaling : CCS
Cell Communication and Signaling, Vol 16, Iss 1, Pp 1-20 (2018)

Background We have previously evidenced apical expression of the 24p3/NGAL/lipocalin-2 receptor (Lcn2-R; SLC22A17) in inner medullary collecting duct (IMCD) cells, which are present in vivo in a hyperosmotic/-tonic environment that activates canonica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59b0b26b81fde7d0f6c44d4a352553f4
http://europepmc.org/articles/PMC6223074

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Additional file 2: of Tonicity inversely modulates lipocalin-2 (Lcn2/24p3/NGAL) receptor (SLC22A17) and Lcn2 expression via Wnt/Î˛-catenin signaling in renal inner medullary collecting duct cells: implications for cell fate and bacterial infection

Autor: R. Betten, B. Scharner, S. Probst, B. Edemir, N. Wolff, C. Langelueddecke, W.-K. Lee, F. ThĂŠvenod

Figure S2. Verification of hLCN2-R isoform B expression in stable CHO-K1 cell transfectants. (A) Reverse transcription PCR of hLCN2-R-isoform B CHO-K1 clone D6.D10. RNA isolation and cDNA synthesis were carried out as described [31]. Primers and cycl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cec0174a6902f94cc2832b1b0cfebfc

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Additional file 1: of Tonicity inversely modulates lipocalin-2 (Lcn2/24p3/NGAL) receptor (SLC22A17) and Lcn2 expression via Wnt/β-catenin signaling in renal inner medullary collecting duct cells: implications for cell fate and bacterial infection

Autor: R. Betten, B. Scharner, S. Probst, B. Edemir, N. Wolff, C. Langelueddecke, W.-K. Lee, F. Thévenod

Figure S1. Hyperosmolarity inhibits proliferation and induces adaptive responses in mIMCD3 cells. (A) Proliferation of mIMCD3 cells cultured in media without (normosmolarity) or with 100 mmol/l urea and NaCl (hyperosmolarity) for 72 h. Measurements o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02987584e2daf29131bfc6454dc2d9c3

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Additional file 4: of Tonicity inversely modulates lipocalin-2 (Lcn2/24p3/NGAL) receptor (SLC22A17) and Lcn2 expression via Wnt/β-catenin signaling in renal inner medullary collecting duct cells: implications for cell fate and bacterial infection

Autor: R. Betten, B. Scharner, S. Probst, B. Edemir, N. Wolff, C. Langelueddecke, W.-K. Lee, F. Thévenod

Figure S4. LPS induces Lcn2 expression and secretion and counteracts the effects of hyperosmolarity on Lcn2 and Lcn2-R expression in mIMCD3 cells. (A) Cells were cultured for 24 h in normosmotic medium with FBS, as described in the Methods and the me

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Additional file 3: of Tonicity inversely modulates lipocalin-2 (Lcn2/24p3/NGAL) receptor (SLC22A17) and Lcn2 expression via Wnt/β-catenin signaling in renal inner medullary collecting duct cells: implications for cell fate and bacterial infection

Autor: R. Betten, B. Scharner, S. Probst, B. Edemir, N. Wolff, C. Langelueddecke, W.-K. Lee, F. Thévenod

Figure S3. β-catenin siRNA reduces β-catenin mRNA expression in mIMCD3 cells exposed to norm- or hyperosmotic media. (A) mIMCD3 cells exposed to norm- or hyperosmotic media for 24 h were transfected with siRNA against β-catenin or control siRNA fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::507f5c6bc4fe5ba206a6fb5772eb75ba

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