Zobrazeno 1 - 10
of 11
pro vyhledávání: '"B E, Witzel"'
Autor:
Kathleen M. Rupprecht, B. E. Witzel, Paul J. Hodges, Karst Hoogsteen, David M. Armistead, Joshua S. Boger, Judith M. Pisano, Robert K. Baker, Robert A. Frankshun
Publikováno v:
ChemInform. 29
Autor:
B. E. Witzel, W. V. Ruyle, Lewis H Sarett, J. Hannah, RW Houser, A. R. Matzuk, T. Y. Shen, H. Jones, W. J. Holtz, K. W. Kelly
Publikováno v:
British Journal of Clinical Pharmacology. 4:7S-13S
1 Diflunisal (MK-647; 5-(2,4-difluorophenyl)-salicylic acid) is a new analgesic anti-inflammatory agent discovered after an extensive chemical and pharmacological study from 1962-71. 2 In the search for a superior salicylate our objectives were highe
Autor:
J, Hannah, W V, Ruyle, H, Jones, A R, Matzuk, K W, Kelly, B E, Witzel, W J, Holtz, R A, Houser, T Y, Shen, L H, Sarett
Publikováno v:
Journal of Medicinal Chemistry. 21:1093-1100
5-(2,4-Difluorophenyl)salicylic acid, diflunisal (25), is the best compound, in terms of both efficacy and safety, from over 500 salicylates investigated in our laboratories. It is a chemically distinct, nonacetylating salicylic acid, more active tha
Publikováno v:
Journal of Medicinal Chemistry. 22:1409-1414
A series of antibacterial N-(omega, omega'-(cycloalkyl, bicyclo[2.2.1]heptyl, and alkyl-substituted phenyl)-sec-alkyl]poly(methylene)triamine and -tetramine hydrochloride salts were synthesized in an effort to develop efficient, nonsystemic inhibitor
Autor:
Arsenio A. Pessolano, T. Y. Shen, J. Carty, Howard Jones, Patricia M. Graham, C. P. Dorn, B. E. Witzel, Robert L Clark
Publikováno v:
Journal of Heterocyclic Chemistry. 22:265-272
Nucleophilic substitution of certain alkyl bromo-2(1H)-pyridones gave some unexpected products where the alkyl group is substituted and the ring bromine is replaced by hydrogen. The expected ring substituted product is also formed, but only as the mi
Autor:
A. A. PESSOLANO, B. E. WITZEL, P. M. GRAHAM, R. L. CLARK, H. JONES, C. P. JUN. DORN, J. CARTY, T. Y. SHEN
Publikováno v:
Chemischer Informationsdienst. 16
Publikováno v:
Chemischer Informationsdienst. 11
Publikováno v:
Journal of pharmaceutical sciences. 71(3)
A series of 14 antibacterial N-[omega,omega'-bis(cycloalkyl, bicyclo[2.2.1]heptyl, and substituted phenyl)-sec-alkyl]-1,3-diamino-2-propanol dihydrochloride salts were synthesized as potential topical antiseptics and disinfectants. Four derivatives w
Publikováno v:
Chemischer Informationsdienst. 13
Autor:
C. G. Van Arman, K. W. Kelly, W. V. Ruyle, H. Jones, J. Hannah, Lewis H Sarett, T. Y. Shen, Charles A. Winter, W. J. Holtz, B. E. Witzel, A. R. Matzuk, V. J. Lotti, R. A. Houser, E. A. Risley
Publikováno v:
Chemischer Informationsdienst. 10