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Acceleration of phosphatidylcholine synthesis and breakdown by inhibitors of mitochondrial function in neuronal cells: a model of the membrane defect of Alzheimer's disease

Autor: S A, Farber, B E, Slack, J K, Blusztajn

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 14(14)

Brain cells in Alzheimer's disease (AD) exhibit a membrane defect characterized by accelerated phospholipid turnover. The mechanism responsible for this defect remains unknown. Recent studies indicate that impairment of mitochondrial function is freq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::73a7bcf52543e33c16a9f862f4d06af2
https://pubmed.ncbi.nlm.nih.gov/11053240

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The m3 muscarinic acetylcholine receptor is coupled to mitogen-activated protein kinase via protein kinase C and epidermal growth factor receptor kinase

Autor: B E, Slack

Publikováno v: The Biochemical journal.

The acetylcholine analogue carbachol rapidly activated mitogen-activated protein kinase (MAPK), and caused tyrosine phosphorylation of the adapter protein p52 Shc and the epidermalgrowth factor (EGF) receptor, in human embryonic kidney cells stably e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2851073d495f0cebd8138a4edaad3baf
https://pubmed.ncbi.nlm.nih.gov/10816433

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Regulation of proteolytic processing of the amyloid beta-protein precursor of Alzheimer's disease in transfected cell lines and in brain slices

Autor: R M, Nitsch, B E, Slack, S A, Farber, J G, Schulz, M, Deng, C, Kim, P R, Borghesani, W, Korver, R J, Wurtman, J H, Growdon

Publikováno v: Journal of neural transmission. Supplementum. 44

beta A4 is the principal component of Alzheimer's disease brain amyloid. It is derived from proteolytic processing of amyloid beta-protein precursors (APP), a family of transmembrane glycoproteins. Secretion of APPs, a secreted proteolytic derivative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ae4b8e8410ddeae809f1bf0ee68ddbb8
https://pubmed.ncbi.nlm.nih.gov/7897393

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Regulation by phorbol esters of amyloid precursor protein release from Swiss 3T3 fibroblasts overexpressing protein kinase C alpha

Autor: B E, Slack, R M, Nitsch, E, Livneh, G M, Kunz, J, Breu, H, Eldar, R J, Wurtman

Publikováno v: The Journal of biological chemistry. 268(28)

Release of large soluble NH2-terminal fragments of the amyloid precursor protein (APP) of Alzheimer's disease was measured in two Swiss 3T3 fibroblast cell lines (designated SF1.4 and SF3.2), overexpressing the alpha subtype of protein kinase C, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7900efd3c19b964792f07d8f40fe2780
https://pubmed.ncbi.nlm.nih.gov/8407946

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Production of diacylglycerol by exogenous phospholipase C stimulates CTP:phosphocholine cytidylyltransferase activity and phosphatidylcholine synthesis in human neuroblastoma cells

Autor: B E, Slack, J, Breu, R J, Wurtman

Publikováno v: The Journal of biological chemistry. 266(36)

The involvement of endogenous diacylglycerol production in the stimulation of phosphatidylcholine synthesis by exogenous phospholipase C was examined using a neuroblastoma (LA-N-2) cell line. Phospholipase C treatment (0.1 unit/ml) of intact cells st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4dd9c59e72f329aecfcf75c013436db5
https://pubmed.ncbi.nlm.nih.gov/1662212

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Choline metabolism in cholinergic neurons: implications for the pathogenesis of neurodegenerative diseases

Autor: R J, Wurtman, J K, Blusztajn, I H, Ulus, I L, Coviella, R L, Buyukuysal, J H, Growdon, B E, Slack

Publikováno v: Advances in neurology. 51

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b7ef9bfe7776f804459864f8e1da768a
https://pubmed.ncbi.nlm.nih.gov/2403709

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Paradoxical resistance to adrenolytic agents of field-stimulated bladder base of rabbit

Autor: B E, Slack, J W, Downie, A, Elbadawi

Publikováno v: The Journal of pharmacology and experimental therapeutics. 220(1)

Isolated circulatory or longitudinally oriented strips from anterior or posterior rabbit bladder base were tested for responsiveness to agonists and sensitivity of field stimulation-induced responses to antagonists. Results were compared to the regio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9190f7bfd91ef5c26929391b45fb82cf
https://pubmed.ncbi.nlm.nih.gov/7053418

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Uptake of exogenous phosphatidylserine by human neuroblastoma cells stimulates the incorporation of [methyl-14C]choline into phosphatidylcholine

Autor: B E, Slack, M, Liscovitch, J K, Blusztajn, R J, Wurtman

Publikováno v: Journal of neurochemistry. 53(2)

The phosphatidylserine (PtdSer) content of human cholinergic neuroblastoma (LA-N-2) cells was manipulated by exposing the cells to exogenous PtdSer, and the effects on phospholipid content, membrane composition, and incorporation of choline into phos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2992d57ebe891ea1eea0aa55d5378b69
https://pubmed.ncbi.nlm.nih.gov/2746233

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