Zobrazeno 1 - 10 of 21 pro vyhledávání: '"B E, KIRK"'
1
The Squalestatins: Synthesis and Biological Activity of Some C3-Modified Analogs; Replacement of a Carboxylic Acid or Methyl Ester with an Isoelectronic Heterocyclic Functionality
Autor: B. E. Kirk, A P Craven, Michael George Lester, D Green, Panayiotis Alexandrou Procopiou, Chuen Chan, R A Henson, Brian Dymock, M J Bamford, Michael A. Snowden
Publikováno v: Journal of Medicinal Chemistry. 38:3502-3513
A series of squalestatins modified at the C3-position with a heterocyclic functionality was prepared and evaluated in vitro as inhibitors of squalene synthase (SQS). Structure-activity relationships for compounds with the 4,6-dimethyloctenoate at C6(
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c42ce4af3af3af4a88d3b5cb7ee842f
https://doi.org/10.1021/jm00018a010
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2
The Squalestatins: Novel Inhibitors of Squalene Synthase. Enzyme Inhibitory Activities and in vivo Evaluation of C1-Modified Analogs
Autor: P A, Procopiou, E J, Bailey, M J, Bamford, A P, Craven, B W, Dymock, J G, Houston, J L, Hutson, B E, Kirk, A D, McCarthy, M, Sareen
Publikováno v: Journal of Medicinal Chemistry. 37:3274-3281
Squalestatin analogues modified in the C1 side chain were prepared and evaluated for their ability to inhibit rat liver microsomal and Candida squalene synthase (SQS) in vitro. While maintaining the 4,6-dimethyloctenoate or 4,6-dimethyloctanoate este
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff321dc4c4e3be2a2b2e341edc448e6a
https://doi.org/10.1021/jm00046a011
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3
The squalestatins: Potent inhibitors of squalene synthase, 3-hydroxymethyl derivatives
Autor: B. E. Kirk, Nigel S. Watson, Anton R. P. Srikantha, Julie L. Hutson, Brian Cox, Keeling Suzanne Elaine
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 4:1931-1936
A series of 3-hydroxymethyl derivatives of squalestatin 1 was prepared as inhibitors of squalene synthase. Potent in vitro inhibitory activity is retained in those analogues which possess C-6 and C-1 substituents analogous to those found in 1.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf22bcd2a21a45efc943f712abee7f42
https://doi.org/10.1016/s0960-894x(01)80537-0
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4
The squalestatins: potent inhibitors of squalene synthase. The role of the tricarboxylic acid moiety
Autor: Nigel S. Watson, B. E. Kirk, Ian P. Steeples, Richard Bell, Chuen Chan, Julia Widdowson, Julie L. Hutson, Brian Cox, Keeling Suzanne Elaine, Panayiotis A. Procopiou
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 3:2541-2546
In squalestatins possessing at C6 either a 4,6-dimethyloctenoate ester or a hydroxyl group, the 5-carboxylic acid is crucial for squalene synthase inhibitory activity. In the former seires, free carboxylic acids are not required at C3 or C4 for poten
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c058c108ed056a6d29b4d7f2b010c83a
https://doi.org/10.1016/s0960-894x(01)80713-7
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5
Inhibitors of cholesterol biosynthesis. 1. 3,5-Dihydroxy-7-(N-imidazolyl)-6-heptenoates and -heptanoates, a novel series of 3-hydroxy-3-methylglutarate-CoA reductase inhibitors
Autor: Julie L. Hutson, D. F. Hayman, Chuen Chan, R. B. Lamont, P. S. Jones, B. E. Kirk, E. J. Bailey, Hartley Cd, Keeling Suzanne Elaine, Graham G. A. Inglis
Publikováno v: Journal of Medicinal Chemistry. 36:3646-3657
3,5-Dihydroxy-7-(N-imidazolyl)heptanoates 4 and the corresponding heptenoates 5 were synthesized as novel classed of potent HMG-CoA reductase (HMGR) inhibitors in which members of the latter series possess enzyme inhibitory activity greater than that
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a44e7ac6d24e7941f26449ad1d11577
https://doi.org/10.1021/jm00075a020
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8
Inhibitors of cholesterol biosynthesis. 1. 3,5-Dihydroxy-7-(N-imidazolyl)-6-heptenoates and -heptanoates, a novel series of HMG-CoA reductase inhibitors
Autor: C, Chan, E J, Bailey, C D, Hartley, D F, Hayman, J L, Hutson, G G, Inglis, P S, Jones, S E, Keeling, B E, Kirk, R B, Lamont
Publikováno v: Journal of medicinal chemistry. 36(23)
3,5-Dihydroxy-7-(N-imidazolyl)heptanoates 4 and the corresponding heptenoates 5 were synthesized as novel classes of potent HMG-CoA reductase (HMGR) inhibitors in which members of the latter series possess enzyme inhibitory activity greater than that
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::672ceb48fe710d5740f482fdedbbee2b
https://pubmed.ncbi.nlm.nih.gov/8246233
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9
Immunofluorescent Cell-Counting Assay for Lymphocytic Choriomeningitis Virus
Autor: B. E. Kirk, Janice M. Webster
Publikováno v: Applied Microbiology. 28:17-21
A quantitative assay for lymphocytic choriomeningitis virus was developed and standardized. The assay is based on direct immunofluorescent staining of infected L-929 cell monolayers and enumeration of cells containing fluorescent viral antigens. Maxi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf46843e0bab9fd2806543a29d1284da
https://doi.org/10.1128/am.28.1.17-21.1974
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10
Neutralizing Antibody Response of Guinea Pigs to Lymphocytic Choriomeningitis Virus
Autor: B. E. Kirk, Janice M. Webster
Publikováno v: Infection and Immunity. 10:516-519
A 24-h neutralization test that is based on fluorescent cell counting was used for the detection and quantitative determination of serum-neutralizing antibody against lymphocytic choriomeningitis virus. The earliest manifestation of serum-neutralizin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f8559e9bf2e1e142bc19f2b4a842239
https://doi.org/10.1128/iai.10.3.516-519.1974
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