Výsledky vyhledávání - "B E, Hedlund"

Protective effects of hydroxyethyl starch-deferoxamine in early sepsis

Autor: D, Moch, B, Schröppel, M H, Schoenberg, H J, Schulz, F C, Thorab, M, Marzinzag, B E, Hedlund, U B, Brückner

Publikováno v: Shock (Augusta, Ga.). 4(6)

The protective effects of hydroxyethyl starch-conjugated deferoxamine (HES-DFO), a macromolecular iron chelator, on the initial pathophysiological cascade in septic shock were evaluated following cecal ligation puncture (CLP) in rats. Animals were gi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::40f0fecf10aacba4d70367e39575ab16
https://pubmed.ncbi.nlm.nih.gov/8608400

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Hydroxyethyl starch deferoxamine, a novel iron chelator, delays diabetes in BB rats

Autor: A M, Roza, D P, Slakey, G M, Pieper, T M, Van Ye, G, Moore-Hilton, R A, Komorowski, C P, Johnson, B E, Hedlund, M B, Adams

Publikováno v: The Journal of laboratory and clinical medicine. 123(4)

Hydroxyl radicals (.OH) may contribute to beta cell death. Because iron catalyzes .OH production, we examined whether administration of a novel, long-acting iron chelator, hydroxyethyl starch-deferoxamine (HES-DFO) could prevent diabetes in spontaneo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3ff856d89d6c68639ce10377f48cee7a
https://pubmed.ncbi.nlm.nih.gov/7511676

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Proposed toxic oxidant inhibitors fail to reduce brain edema

Autor: K D, Judy, G B, Bulkley, B E, Hedlund, D M, Long

Publikováno v: Acta neurochirurgica. Supplementum. 60

Toxic oxidants (oxygen free radicals) have been implicated in the formation of brain edema from ischemia-reperfusion injury or tumor growth. We investigated the ability of an iron chelator, a calcium channel blocker, and a xanthine oxidase inhibitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::025915accd2866e4474ea80042f3fe36
https://pubmed.ncbi.nlm.nih.gov/7976665

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Proposed Toxic Oxidant Inhibitors Fail to Reduce Brain Edema

Autor: Donlin M. Long, G. B. Bulkley, B. E. Hedlund, K. D. Judy

Publikováno v: Brain Edema IX ISBN: 9783709193365

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c37af0fa64c985fd85b4c4ac2778404
https://doi.org/10.1007/978-3-7091-9334-1_23

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Polymer conjugation reduces deferoxamine induced retinopathy in an albino rat model

Autor: P L, Gehlbach, R L, Purple, P E, Hallaway, B E, Hedlund

Publikováno v: Investigative ophthalmologyvisual science. 34(10)

The iron chelating agent deferoxamine mesylate USP (Desferal, Ciba, Summit, NJ) is commonly used in the treatment of acute iron intoxication and chronic iron overload (associated with the transfusion-dependent anemias). When used for prolonged period

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a043270264958c40f86318a2ed6da4fb
https://pubmed.ncbi.nlm.nih.gov/7689545

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Acute Resuscitation and Antioxidant Therapy

Autor: B. E. Hedlund, P. E. Hallaway

Publikováno v: Host Defense Dysfunction in Trauma, Shock and Sepsis ISBN: 9783642774072

The following discussion is divided into two parts. The first deals with the role of iron in the genesis of tissue injury occurring during regional or global ischemia and subsequent reperfusion. The second pertains to current practices of fluid repla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::095449e2dcd56998afca20825e07a2c9
https://doi.org/10.1007/978-3-642-77405-8_164

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Role of iron and oxygen radicals in hemorrhage and shock

Autor: P. E. Hallaway, B. E. Hedlund

Publikováno v: Klinische Wochenschrift. 69(21-23)

This contribution focuses on the role of iron as a critical component in the genesis of oxygen radical mediated tissue injury occurring after global ischemia associated with severe hypovolemic shock. Conventional colloid or crystalloid fluid resuscit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afbf58aef998782b430f2060cc28e9e9
https://pubmed.ncbi.nlm.nih.gov/1798288

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Quantitative microanalysis of equine synovial fluid glycosaminoglycan concentration

Autor: C B, Little, B J, Hilbert, S, Wickstrom, B E, Hedlund

Publikováno v: American journal of veterinary research. 51(10)

An alcian blue precipitation method for quantifying the hyaluronic acid (HA) and sulphated glycosaminoglycan concentration (SGAG) in solutions containing both compounds was assessed. The assay was found to be rapid and reliable in solutions containin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::40b66e1f0ae4c4d175964f992d2121a1
https://pubmed.ncbi.nlm.nih.gov/2240772

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