Zobrazeno 1 - 10 of 40 pro vyhledávání: '"B E, Bierer"'
2
Recombinant human interleukin-1 receptor antagonist in the treatment of steroid-resistant graft-versus-host disease
Autor: J H, Antin, H J, Weinstein, E C, Guinan, P, McCarthy, B E, Bierer, D G, Gilliland, S K, Parsons, K K, Ballen, I J, Rimm, G, Falzarano
Publikováno v: Blood. 84:1342-1348
Acute graft-versus-host disease (GVHD) that is resistant to therapy is a highly lethal complication of marrow transplantation. Inflammatory cytokines such as interleukin-1 (IL-1) may be critical mediators of this process. If so, specific inhibition o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014548cb248f00dd7a04e462bd0e07f2
https://doi.org/10.1182/blood.v84.4.1342.bloodjournal8441342
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3
Immunosuppressants FK506 and rapamycin function as reversal agents of the multidrug resistance phenotype
Autor: R J, Arceci, K, Stieglitz, B E, Bierer
Publikováno v: Blood. 80:1528-1536
The multidrug-resistant (MDR) phenotype is characterized in vitro by the resistance displayed by cell lines to a broad spectrum of natural product cytotoxic agents. This high level of cross-resistance is due to the increased expression of a membrane
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ba039a806bae569c0e8e4cde8f29c3
https://doi.org/10.1182/blood.v80.6.1528.bloodjournal8061528
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4
Selective depletion of bone marrow T lymphocytes with anti-CD5 monoclonal antibodies: effective prophylaxis for graft-versus-host disease in patients with hematologic malignancies
Autor: J H, Antin, B E, Bierer, B R, Smith, J, Ferrara, E C, Guinan, C, Sieff, D E, Golan, R M, Macklis, N J, Tarbell, E, Lynch
Publikováno v: Blood. 78:2139-2149
Seventy-one patients with hematologic malignancies received bone marrow from a histocompatible sibling (n = 48) or a partially matched relative (n = 23) that had been depleted of CD5+ T cells with either an anti-CD5 mooclonal antibody (MoAb) plus com
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af8ff16973f9f5603ca9c012283b2cb7
https://doi.org/10.1182/blood.v78.8.2139.bloodjournal7882139
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6
Suppression of human IL-1beta, IL-2, IFN-gamma, and TNF-alpha production by cigarette smoke extracts
Autor: Y, Ouyang, N, Virasch, P, Hao, M T, Aubrey, N, Mukerjee, B E, Bierer, B M, Freed
Publikováno v: The Journal of allergy and clinical immunology. 106(2)
Although cigarette smoking is known to have detrimental effects on the immune system, the nature of the immunosuppressive agent or agents is poorly understood.The purpose of the current study was to evaluate the effects of cigarette smoke extracts fr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::834fbc752f7ea70d6531f82f2ec833d1
https://pubmed.ncbi.nlm.nih.gov/10932071
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7
Uncoupling activation-dependent HS1 phosphorylation from nuclear factor of activated T cells transcriptional activation in Jurkat T cells: differential signaling through CD3 and the costimulatory receptors CD2 and CD28
Autor: J E, Hutchcroft, J M, Slavik, H, Lin, T, Watanabe, B E, Bierer
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 161(9)
CD3, CD2, and CD28 are functionally distinct receptors on T lymphocytes. Engagement of any of these receptors induces the rapid tyrosine phosphorylation of a shared group of intracellular signaling proteins, including Vav, Cbl, p85 phosphoinositide 3
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bfd254823882207d7f0ea00cef699311
https://pubmed.ncbi.nlm.nih.gov/9794375
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8
Association of p59(fyn) with the T lymphocyte costimulatory receptor CD2. Binding of the Fyn Src homology (SH) 3 domain is regulated by the Fyn SH2 domain
Autor: H, Lin, J E, Hutchcroft, C E, Andoniou, M, Kamoun, H, Band, B E, Bierer
Publikováno v: The Journal of biological chemistry. 273(31)
Human CD2 is a 50-55-kDa cell surface receptor specifically expressed on the surface of T lymphocytes and NK cells. Stimulation of human peripheral blood T cells with mitogenic pairs of anti-CD2 monoclonal antibodies (mAbs) is sufficient to induce in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d85ce17507a56d87e7abb62d418fd1fc
https://pubmed.ncbi.nlm.nih.gov/9677430
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9
Gene immunotherapy in murine acute myeloid leukemia: granulocyte-macrophage colony-stimulating factor tumor cell vaccines elicit more potent antitumor immunity compared with B7 family and other cytokine vaccines
Autor: K, Dunussi-Joannopoulos, G, Dranoff, H J, Weinstein, J L, Ferrara, B E, Bierer, J M, Croop
Publikováno v: Blood. 91(1)
In an attempt to explore novel treatment modalities in acute myeloid leukemia (AML), we studied the role of costimulatory and cytokine gene immunotherapy in murine AML. We have previously shown that leukemic mice can be cured with CD80 transfected le
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::12ae4192dae825b8c9dc2dfc83dcdf29
https://pubmed.ncbi.nlm.nih.gov/9414288
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10
Treatment of chronic graft-versus-host disease with clofazimine
Autor: S J, Lee, S A, Wegner, C J, McGarigle, B E, Bierer, J H, Antin
Publikováno v: Blood. 89(7)
Clofazimine (Lamprene) is an antimycobacterial drug that has antiinflammatory activity in a number of chronic autoimmune skin disorders. We report 22 patients treated with clofazimine for chronic graft-versus-host disease (cGVHD). The initial dose wa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e6dd21f126b83c3e99977e162ffb9c32
https://pubmed.ncbi.nlm.nih.gov/9116272
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