Zobrazeno 1 - 10
of 20
pro vyhledávání: '"B D Given"'
Autor:
B D Given, J Galloway, Paul A. Rue, W. Pugh, Theodore Karrison, B Frank, Kenneth S. Polonsky, J. Licinio-Paixao
Publikováno v:
Journal of Clinical Investigation. 77:98-105
We undertook this study to examine the accuracy of plasma C-peptide as a marker of insulin secretion. The peripheral kinetics of biosynthetic human C-peptide (BHCP) were studied in 10 normal volunteers and 7 insulin-dependent diabetic patients. Each
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e3e4857191210cf30520da11e0716d2
https://doi.org/10.1172/jci112308
https://doi.org/10.1172/jci112308
Autor:
Donald F. Steiner, S. Nishimura, Tokio Sanke, Arthur H. Rubenstein, Kei Miyamura, S. J. Chan, Kishio Nanjo, Howard S. Tager, M. Miyano, K. Inouye, B D Given, Kenneth S. Polonsky, M. Kondo
Publikováno v:
Diabetologia. 30:87-92
We describe a family from Japan displaying the mutant insulin syndrome with hyperinsulinaemia and an increased insulin: C-peptide molar ratio. Serum insulin isolated from several family members showed reduced in vitro biological activity, and analysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da64eafa7c558a9e8c74d0da08ed9782
https://doi.org/10.1007/bf00274577
https://doi.org/10.1007/bf00274577
Autor:
Mary A Root, Julio Licinio-Paixao, Kenneth S. Polonsky, Bruce Hill Frank, Howard S. Tager, Paul A. Rue, B D Given, Sally A. Provow, Robert M. Cohen, Arthur H. Rubenstein
Publikováno v:
Metabolism. 35:1137-1146
Two new radioimmunoassays for human proinsulin (hPI) have been developed and used to study patients with islet cell tumors and familial hyperproinsulinemia. Both antisera were adsorbed against human C-peptide conjugated to Sepharose, following which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edcd9b8e5706585902c9ace985fffef2
https://doi.org/10.1016/0026-0495(86)90027-2
https://doi.org/10.1016/0026-0495(86)90027-2
Autor:
Arthur H. Rubenstein, James J Markese, Mary E. Mako, B D Given, Howard S. Tager, Russel Poucher, Masashi Kobayashi, O. Kolterman, Jerrold M. Olefsky, D. Baldwin
Publikováno v:
Nature. 281:122-125
Insulin isolated from the pancreas of a diabetic patient with fasting hyperinsulinaemia showed decreased activity in binding to cell membrane insulin receptors and in stimulating cellular 2-deoxyglucose transport and glucose oxidation. Chemical studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::511e391f2c2635f8fdde03737923a23a
https://doi.org/10.1038/281122a0
https://doi.org/10.1038/281122a0
Autor:
Masashi Kobayashi, Howard S. Tager, B D Given, Mary E. Mako, Arthur H. Rubenstein, Russel Poucher, Orville G. Kolterman, James J Markese, David S. Baldwin, Jerrold M. Olefsky
Publikováno v:
New England Journal of Medicine. 302:129-135
A 51-year-old, nonobese man with diabetes mellitus had marked hyperinsulinemia (70 to 120 muU per milliliter; 502 to 860 pmol per liter) and fasting hyperglycemia (140 to 170 mg per 100 ml; 7.8 to 9.4 mmol per liter). Plasma proinsulin, glucagon, gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800ab671e9b0e16d6413488f85f35d23
https://doi.org/10.1056/nejm198001173020301
https://doi.org/10.1056/nejm198001173020301
Publikováno v:
Journal of Clinical Investigation. 81:442-448
The pattern of endogenous insulin secretion over a 24-h period, which included three mixed meals, was evaluated in 14 normal volunteers and 15 obese subjects. Insulin secretory rates were calculated from plasma C-peptide levels using individually der
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060329c8035f402c651de4f3e4f296fa
https://doi.org/10.1172/jci113339
https://doi.org/10.1172/jci113339
Autor:
E. Van Cauter, John A Galloway, Kenneth S. Polonsky, Bruce H. Frank, E. T. Shapiro, B D Given, H Tillil, Lawrence Hirsch, C Beebe
Publikováno v:
New England Journal of Medicine. 318:1231-1239
To determine whether non-insulin-dependent diabetes is associated with specific alterations in the pattern of insulin secretion, we studied 16 patients with untreated diabetes and 14 matched controls. The rates of insulin secretion were calculated fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b71e15b2aab23a68f5aa48a5c26e234
https://doi.org/10.1056/nejm198805123181903
https://doi.org/10.1056/nejm198805123181903
Autor:
H. Tillil, E. T. Shapiro, B. D. Given, P. Rue, A. H. Rubenstein, J. A. Galloway, K. S. Polonsky
Publikováno v:
Diabetes. 37:1195-1201
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::633324feb4bf4c85232980932f3bbe52
https://doi.org/10.2337/diabetes.37.9.1195
https://doi.org/10.2337/diabetes.37.9.1195
Autor:
James A. Horner, Masashi Kobayashi, Fiser Rh, B D Given, Arthur H. Rubenstein, Joycelyn M. Elders, Raymond L. Hintz, Jerrold M. Olefsky, Heinrich K. Schedwie, Mary E. Mako
Publikováno v:
Proceedings of the National Academy of Sciences. 75:3469-3473
We have studied a 2-year-old girl with acanthosis nigricans, glucose intolerance, marked hyperinsulinemia, and somatic features characteristic of the leprechaunism syndrome. Circulating plasma insulin levels were increased up to 50-fold and the patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070427d23870a2f0a4422008d9e2deb8
https://doi.org/10.1073/pnas.75.7.3469
https://doi.org/10.1073/pnas.75.7.3469
Autor:
B. D. Given
Publikováno v:
Archives of Internal Medicine. 145:281-285
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58b525efca9a340533e9cc79fbc70012
https://doi.org/10.1001/archinte.145.2.281
https://doi.org/10.1001/archinte.145.2.281