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The neurosteroid 5β-pregnan-3α-ol-20-one enhances actions of etomidate as a positive allosteric modulator of α1β2γ2L GABAA receptors

Autor: P, Li, J R, Bracamontes, B D, Manion, S, Mennerick, J H, Steinbach, A S, Evers, G, Akk

Publikováno v: British journal of pharmacology. 171(23)

Neurosteroids potentiate responses of the GABAA receptor to the endogenous agonist GABA. Here, we examined the ability of neurosteroids to potentiate responses to the allosteric activators etomidate, pentobarbital and propofol.Electrophysiological as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e1c446857aa147810cf074a327a79e85
https://pubmed.ncbi.nlm.nih.gov/25117207

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Mechanisms of potentiation of the mammalian GABAA receptor by the marine cembranoid eupalmerin acetate

Autor: P, Li, D E, Reichert, A D, Rodríguez, B D, Manion, A S, Evers, V A, Eterović, J H, Steinbach, G, Akk

Publikováno v: British journal of pharmacology. 153(3)

Eupalmerin acetate (EPA) is a marine diterpene compound isolated from the gorgonian octocorals Eunicea succinea and Eunicea mammosa. The compound has been previously shown to modulate muscle-type and neuronal nicotinic acetylcholine receptors, which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e2bf05325f1d98f6949bf6769b39ea90
https://pubmed.ncbi.nlm.nih.gov/18037909

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