Výsledky vyhledávání

Long-term in vivo expression of a murine adenosine deaminase gene in rhesus monkey hematopoietic cells of multiple lineages after retroviral mediated gene transfer into CD34+ bone marrow cells

Autor: D M, Bodine, T, Moritz, R E, Donahue, B D, Luskey, S W, Kessler, D I, Martin, S H, Orkin, A W, Nienhuis, D A, Williams

Publikováno v: Blood. 82:1975-1980

Retroviral mediated gene transfer into stem cells has been proposed as therapy for many inherited hematopoietic diseases. Deficiency of the enzyme adenosine deaminase (ADA) results in depletion of T lymphocytes, causing severe combined immunodeficien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d5a1f4074561461b3628f99756a442f
https://doi.org/10.1182/blood.v82.7.1975.1975

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Mitoguazone therapy in patients with refractory or relapsed AIDS-related lymphoma: results from a multicenter phase II trial

Autor: B D Luskey, Byron M. Espina, F Giles, D. Tessman, Anil Tulpule, D. H. Von Hoff, Lee M. Kaplan, David T. Scadden, I Silverberg, J Wernz, Alexandra M. Levine, D W Northfelt

Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 15(3)

PURPOSE Patients with AIDS-related lymphoma usually have extensive lymphomatous disease, with relatively frequent involvement of the CNS. Approximately half may achieve complete remission after chemotherapy. Mitoguazone, an inhibitor of polyamine bio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a6ddc8b23dd0ef108057dfed96b43b
https://pubmed.ncbi.nlm.nih.gov/9060550

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Functional expression of human CD8 in fully reconstituted mice after retroviral-mediated gene transfer of hemopoietic stem cells

Autor: G A, Holländer, B D, Luskey, D A, Williams, S J, Burakoff

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 149(2)

Retroviral-mediated gene transfer has been used in an attempt to efficiently and stably express functional cell-surface molecules in lymphoid and myeloid cells. The human CD8 molecule is a T cell-specific surface receptor that is intimately involved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1c0754bb55019e268268bffa8052c708
https://pubmed.ncbi.nlm.nih.gov/1624791

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Stem cell factor, interleukin-3, and interleukin-6 promote retroviral-mediated gene transfer into murine hematopoietic stem cells

Autor: B D, Luskey, M, Rosenblatt, K, Zsebo, D A, Williams

Publikováno v: Blood. 80(2)

The efficiency of retroviral-mediated gene transfer into hematopoietic stem cells (HSC) is dependent on the survival and self-renewal of HSC in vitro during retroviral infection. We have examined the effect of prestimulation of bone marrow with vario

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e5b4176b29ffbc0f8a03a6c5b72df20c
https://pubmed.ncbi.nlm.nih.gov/1378319

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Retroviral-mediated gene transfer of human adenosine deaminase into murine hematopoietic cells

Autor: J F, Apperley, B D, Luskey, D A, Williams

Publikováno v: Seminars in hematology. 28(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7e524dbece886f5ba82263d19dab169d
https://pubmed.ncbi.nlm.nih.gov/1876864

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Purification of coated vesicles by agarose gel electrophoresis

Autor: B D Luskey, R E Fine, James E. Rothman, John L.R. Rubenstein

Publikováno v: The Journal of Cell Biology

We have applied agarose gel electrophoresis as a novel step in the purification of clathrin-coated vesicles. Preparations of coated vesicles obtained by sedimentation velocity and isopycnic centrifugation are resolved into two distinct fractions upon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1136c37827f926838ce5bb2133e0c72
http://europepmc.org/articles/PMC2111692

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