Zobrazeno 1 - 10
of 30
pro vyhledávání: '"B D, Korant"'
Publikováno v:
Biochemical Journal. 290:797-800
Poliovirus protease 3C is a cysteine enzyme that is essential for the processing of the viral precursor polyprotein containing structural proteins and enzymes, including the protease itself. We have constructed the plasmid pSD/PV3C which produced pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5b3a2e26da71677ed0b078676220438
https://doi.org/10.1042/bj2900797
https://doi.org/10.1042/bj2900797
Publikováno v:
Advances in experimental medicine and biology. 436
Cleavage of non-viral proteins is rarely observed with the HIV-1 protease (HIV pr). One such cleavage event occurs with bcl-2, an important cytoprotective protein. The loss of bcl-2 has biological consequences, leading to enhanced HIV replication and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::87c6e7c6edd5e5bb648ead76e8818c00
https://pubmed.ncbi.nlm.nih.gov/9561195
https://pubmed.ncbi.nlm.nih.gov/9561195
Autor:
D. D. Mccabe, E. E. Huston, R. J. Deloskey, Ronald M. Klabe, Patrick Y.S. Lam, Hodge Carl Nicholas, C.-H. Chang, C. J. Rizzo, B. D. Korant, Paul J. Ala, J. L. Duke
Publikováno v:
Biochemistry. 36(7)
In cell cultures, the key residues associated with HIV-1 resistance to cyclic urea-based HIV-1 protease (PR) inhibitors are Val82 and Ile84 of HIV-1 PR. To gain an understanding of how these two residues modulate inhibitor binding, we have measured t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d7d9e24ba0290f1b74106b55ed3344
https://pubmed.ncbi.nlm.nih.gov/9048541
https://pubmed.ncbi.nlm.nih.gov/9048541
Autor:
B D, Korant, C J, Rizzo
Publikováno v:
Advances in experimental medicine and biology. 421
New, potent therapies for HIV disease are available, based on synthetic inhibitors of the viral protease, an essential viral enzyme. The results in clinical trials have been impressive with most treated individuals benefiting in terms of reduced quan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3a89f49eaa80265be56046f391eecd14
https://pubmed.ncbi.nlm.nih.gov/9330709
https://pubmed.ncbi.nlm.nih.gov/9330709
Autor:
C J, Rizzo, B D, Korant
Publikováno v:
Methods in enzymology. 241
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5e125de71f9b65d47331c496503a2627
https://pubmed.ncbi.nlm.nih.gov/7854177
https://pubmed.ncbi.nlm.nih.gov/7854177
Publikováno v:
Journal of natural products. 56(8)
In order to find new effective HIV protease inhibitors, two diterpenes (carnosic acid [1] and carnosol [5]) were isolated from rosemary (Rosmarinus officinalis L.), and rosmanol [2] and semisynthetic derivatives (7-O-methylrosmanol [3], 7-O-ethylrosm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5928eed0a88eb2f02c5209a5f1892427
https://pubmed.ncbi.nlm.nih.gov/8229021
https://pubmed.ncbi.nlm.nih.gov/8229021
Publikováno v:
Advances in experimental medicine and biology. 312
A 450 nucleotide sequence corresponding to the nucleotides 1931-2380 of the viral genome (8) was amplified by polymerase chain reaction (PCR) using template DNA prepared from HIV-2 (ROD) infected H9 cells. The sequence codes for HIV-2 protease and it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::204f66c069b6c52103e0b1e619b91351
https://pubmed.ncbi.nlm.nih.gov/1514447
https://pubmed.ncbi.nlm.nih.gov/1514447
Autor:
B D, Korant, C J, Rizzo
Publikováno v:
Advances in experimental medicine and biology. 306
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1bc2e971a4b0e134d1308e906ede92c7
https://pubmed.ncbi.nlm.nih.gov/1812739
https://pubmed.ncbi.nlm.nih.gov/1812739
Autor:
B D, Korant, C J, Rizzo
Publikováno v:
Biomedica biochimica acta. 50(4-6)
Based on a variety of independent assays, the expression of HIV (human immunodeficiency virus type 1) protease in living bacterial cells results in their loss of viability. Although the mechanism is not proven, we have observed degradation of cellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7a5f1c9f7f141b8ed5f57da66cee85aa
https://pubmed.ncbi.nlm.nih.gov/1801736
https://pubmed.ncbi.nlm.nih.gov/1801736
Autor:
B D, Korant
Publikováno v:
Acta biologica Hungarica. 42(1-3)
Many animal and plant viruses encode proteolytic enzymes which are involved in regulation of viral replication and assembly. The proteases are becoming well-characterized, and offer attractive features for the design of selective antiviral agents. Ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::75d86819b573076b82e8edb367be8a09
https://pubmed.ncbi.nlm.nih.gov/1844311
https://pubmed.ncbi.nlm.nih.gov/1844311