Výsledky vyhledávání - "B D, Haehner"

Stereoselective sulfoxidation of sulindac sulfide by flavin-containing monooxygenases. Comparison of human liver and kidney microsomes and mammalian enzymes

Autor: M A, Hamman, B D, Haehner-Daniels, S A, Wrighton, A E, Rettie, S D, Hall

Publikováno v: Biochemical pharmacology. 60(1)

The stereoselective sulfoxidation of the pharmacologically active metabolite of sulindac, sulindac sulfide, was characterized in human liver, kidney, and cDNA-expressed enzymes. Kinetic parameter estimates (pH = 7.4) for sulindac sulfoxide formation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::66df01d9756598ab3e3a4534cef745c5
https://pubmed.ncbi.nlm.nih.gov/10807940

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Bimodal distribution of renal cytochrome P450 3A activity in humans

Autor: B D, Haehner, J C, Gorski, M, Vandenbranden, S A, Wrighton, S K, Janardan, P B, Watkins, S D, Hall

Publikováno v: Molecular pharmacology. 50(1)

It has been proposed that excessive intrarenal conversion of cortisol to 6 beta-hydroxycortisol by CYP3A may mediate increased tubular reabsorption of sodium, leading to a state of mild volume expansion and the clinical phenotype of salt-sensitive hy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0ef0b2b19596add3a46907b1f7fd8169
https://pubmed.ncbi.nlm.nih.gov/8700118

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