Zobrazeno 1 - 10
of 29
pro vyhledávání: '"B C Richardson"'
Publikováno v:
Lupus (Los Angeles)
Objectives Lupus flares are triggered by environmental agents that cause oxidative stress, but the mechanisms involved are unclear. The flares are characterized by oxidative modifications of proteins by 4-hydroxynonenals, malondialdehydes, carbonyls
Publikováno v:
The Journal of Immunology. 159:1303-1309
DNA methylation, a mechanism modifying gene expression, is mediated in part by the enzyme DNA methyltransferase. Reduced levels of T cell DNA methyltransferase have been observed in lupus-like diseases, and increased levels have been reported in mali
Publikováno v:
The Journal of Immunology. 154:3025-3035
Treating activated CD4+ T cells with DNA methyltransferase inhibitors modifies gene expression and induces autoreactivity. Adoptive transfer of viable polyclonal autoreactive cells causes a lupus-like disease, most likely because of one or more effec
Autor:
D. Amedeo, V. P. Lytwyn, C. Philo, B. C. Richardson, M. Blacksell, M. R. Curry, M. Turner, F. Driver, Michael Heffernan, H. Clout, D. D. Arreola, D. Turnock, D. Cosgrove, P. Glennie, G. V. Cooper, T. M. Whitmore, A. Warren, D. J.B. Shaw, D. R. Green, P. O. Chalita, C. H. Richardson, K. J. Meyer-Arendt, G. Claeys, S. J. Hornsby, S. Copley, Neil Roberts, Charles Withers, A. G. Macpherson, D. C. Lai, T. F. McIlwraith, J. A. Jakle, W. G. Lovell, T. F. Glick, Morag Bell, S. R. Brooker-Gross, M. J. Daunton
Publikováno v:
Journal of Historical Geography. 19:74-123
Autor:
S. A. Goss, E. C. Burdette, Gregory K. Ogilvie, H. A. Reynolds, C. W. Badger, B. C. Richardson
Publikováno v:
International Journal of Hyperthermia. 6:697-705
A multi-element ultrasound hyperthermia system (Labthermics Technologies, Inc., Sonotherm 1000) was utilized to deliver energy to two relatively well-defined regions (3.8 X 3.8 cm) on the lateral aspect of the right rear leg of 22 dogs in 1, 2 and 3
Publikováno v:
Arthritis and rheumatism. 44(2)
Previous studies have shown that inhibiting T cell DNA methylation causes a lupus-like disease by modifying gene expression. T cells from patients with lupus exhibit diminished levels of DNA methyltransferase (MTase) enzyme activity, hypomethylated D
Publikováno v:
Immunological investigations. 29(4)
Overexpressing LFA-1 (CD11a/CD18) on antigen specific CD4+ T cells makes the cells proliferate to normally subthreshold stimuli, including self-Ia molecules without specific antigen. The mechanisms by which this occurs are unknown, but potentially in
Publikováno v:
Immunological investigations. 29(4)
Inducing T cell LFA-1 overexpression by transfection, or by treatment with DNA methylation inhibitors including 5-azacytidine, procainamide and hydralazine, causes MHC-specific T cell autoreactivity in vitro and autoimmunity in vivo. How DNA methylat
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 159(3)
DNA methylation, a mechanism modifying gene expression, is mediated in part by the enzyme DNA methyltransferase. Reduced levels of T cell DNA methyltransferase have been observed in lupus-like diseases, and increased levels have been reported in mali
Autor:
N G, Singer, B C, Richardson, D, Powers, F, Hooper, F, Lialios, J, Endres, C M, Bott, D A, Fox
Publikováno v:
Immunology. 88(4)
CD6 is a 130 000 MW T-cell surface glycoprotein that can deliver coactivating signals to mature T lymphocytes. Studies using monoclonal antibodies (mAb) have defined at least four epitopes on CD6, and distinct functional responses are elicited by mAb