Výsledky vyhledávání - "B C, Sweatman"

Mass directed peak selection, an efficient method of drug metabolite identification using directly coupled liquid chromatography–mass spectrometry–nuclear magnetic resonance spectroscopy

Autor: Jeremy K. Nicholson, John C. Lindon, B. C. Sweatman, J. Ayrton, R. S. Plumb, Gordon J. Dear, I. M. Ismail

Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications. 748:281-293

Mass spectrometry (both MS and MS-MS) has been used to determine which eluting chromatography peaks in an LC-MS-nuclear magnetic resonance (NMR) experiment should be selected for extended NMR spectroscopic measurement. This mass directed selection of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca058719e238c33d08d0ebfb2d82b1c1
https://doi.org/10.1016/s0378-4347(00)00291-7

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The use of preparative high performance liquid chromatography with tandem mass spectrometric directed fraction collection for the isolation and characterisation of drug metabolites in urine by nuclear magnetic resonance spectroscopy and liquid chromatography/sequential mass spectrometry

Autor: J. Ayrton, Gordon J. Dear, B. C. Sweatman, Robert S. Plumb, I. M. Ismail

Publikováno v: Rapid Communications in Mass Spectrometry. 13:845-854

Preparative high performance liquid chromatography (HPLC) coupled to tandem mass spectrometry has been used successfully for the isolation of several drug metabolites from urine. Nuclear magnetic resonance (NMR) spectroscopy has been employed to dete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55011dde9508b3bd80abc46524ddbfc6
https://doi.org/10.1002/(sici)1097-0231(19990530)13:10<845::aid-rcm556>3.0.co

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Tandem mass spectrometry linked fraction collection for the isolation of drug metabolites from biological matrices

Autor: B. C. Sweatman, I. M. Ismail, Gordon J. Dear, R. S. Plumb, J. Ayrton

Publikováno v: Rapid Communications in Mass Spectrometry. 13:886-894

An automated mass spectrometric linked fraction collection system is described which enables on-line examination of isolated components based on molecular-ion and product-ion information. This system has been used successfully to specifically isolate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aab1cdbfc6954761385f17d7c401290f
https://doi.org/10.1002/(sici)1097-0231(19990530)13:10<886::aid-rcm577>3.0.co

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Assignment of the 1H, 19F, and 13C NMR spectra of 2-deoxy-2-fluoro-d-ribose and characterisation of the isomeric equilibrium

Autor: R. Duncan Farrant, Paul N. Sanderson, John C. Lindon, B. C. Sweatman

Publikováno v: Carbohydrate Research. 284:51-60

The assignment of the 1 H, 19 F, and 13 C NMR chemical shifts and coupling constants of 2-deoxy-2-fluoro- d -ribose, an important intermediate in the synthesis of antiviral nucleoside drugs, is reported and the NMR spectra are used to determine the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94d34e7a85171f170515913f90a3a7cb
https://doi.org/10.1016/0008-6215(96)00020-1

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Hplc-nmr identification of the human urinary metabolites of (—)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, a nucleoside analogue active against human immunodeficiency virus (HIV)

Autor: R. D. Farrant, John P. Shockcor, John C. Lindon, Paul N. Sanderson, L W Frick, R M Wurm, B. C. Sweatman

Publikováno v: Xenobiotica. 26:189-199

1. Human urine samples from a clinical trial of the anti-HIV compound (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-cyto sin e (BW524W91) have been analysed using 19F-nmr and 1H-hplc-nmr spectroscopy. 2. The identities and relative level

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba19d36b483e35168cdb8f7486bbc55d
https://doi.org/10.3109/00498259609046699

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Automatic reduction of NMR spectroscopic data for statistical and pattern recognition classification of samples

Autor: Peter Neidig, Elaine Holmes, P. Kessler, R. D. Farrant, C. R. Beddell, John C. Lindon, Jeremy K. Nicholson, Salman R. Salman, B. C. Sweatman, Manfred Spraul, U. Klauck, E. Rahr

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 12:1215-1225

A general method of automatically reducing NMR spectra to provide numerical descriptors of samples has been developed and investigated. These descriptors can be used as input to pattern recognition or multivariate algorithms for sample classification

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0bb184f2123ffbc442bbbec189ac18a
https://doi.org/10.1016/0731-7085(94)00073-5

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600 MHz 1H-NMR spectroscopy of human cerebrospinal fluid: Effects of sample manipulation and assignment of resonances

Autor: B. C. Sweatman, John C. Lindon, Jeremy K. Nicholson, Farida Y. K. Ghauri, R. Duncan Farrant, Elaine Holmes

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 11:651-664

Extensive assignments of resonances in the 600 MHz 1 H-NMR spectra of cerebrospinal fluid are reported. These have been achieved by the measurement of a combination of two-dimensional experiments comprising homonuclear J-resolved, COSY45, and double-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f163572309fe80ddae53a547459767
https://doi.org/10.1016/0731-7085(93)80171-v

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NMR spectroscopy of human post mortem cerebrospinal fluid: Distinction of Alzheimer's disease from control using pattern recognition and statistics

Autor: C. R. Beddell, John C. Lindon, Nigel J. Cairns, Jeremy K. Nicholson, B. C. Sweatman, Farida Y. K. Ghauri, John Wood

Publikováno v: NMR in Biomedicine. 6:163-167

1H NMR spectra have been measured at 500 and 600 MHz on 23 human cerebrospinal fluid samples obtained at autopsy from Alzheimer's disease patients and controls. The spectra at 500 MHz were quantified using 42 descriptors based on NMR peak heights and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5930a6ffc65cd4024c74a557eb8e8e6
https://doi.org/10.1002/nbm.1940060210

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