Zobrazeno 1 - 8
of 8
pro vyhledávání: '"B C, Hancock"'
Autor:
B C, Hancock, M, Parks
Publikováno v:
Pharmaceutical research. 17(4)
To evaluate the magnitude of the solubility advantage for amorphous pharmaceutical materials when compared to their crystalline counterparts.The thermal properties of several drugs in their amorphous and crystalline states were determined using diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e43a78d8adc14ee40c132437932049be
https://pubmed.ncbi.nlm.nih.gov/10870982
https://pubmed.ncbi.nlm.nih.gov/10870982
Publikováno v:
Journal of pharmaceutical sciences. 89(3)
The molecular mobility of amorphous pharmaceutical materials is known to be a key factor in determining their stability, reactivity, and physicochemical properties. Usually such molecular mobility is quantified using relaxation time constants. Typica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b29165ec577cdb224c39c37edced6968
https://pubmed.ncbi.nlm.nih.gov/10707021
https://pubmed.ncbi.nlm.nih.gov/10707021
Publikováno v:
Pharmaceutical research. 16(5)
To evaluate thermomechanical analysis (TMA) as a technique for determining the viscosity of amorphous pharmaceutical materials. This property of amorphous drugs and excipients is related to their average rate of molecular mobility and thus to their p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a204fdcb2f09cabbbfc6e40d0ec20f98
https://pubmed.ncbi.nlm.nih.gov/10350009
https://pubmed.ncbi.nlm.nih.gov/10350009
Publikováno v:
Pharmaceutical research. 15(11)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dcc3eaf7a211bd86f1765b373a566d8d
https://pubmed.ncbi.nlm.nih.gov/9833982
https://pubmed.ncbi.nlm.nih.gov/9833982
Publikováno v:
Pharmaceutical research. 15(5)
To evaluate a simple calorimetric method for estimating the fragility of amorphous pharmaceutical materials from the width of the glass transition region.The glass transition temperature regions of eleven amorphous pharmaceutical materials were chara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c68bf59ca0ba0f93b4ec1a96666310a7
https://pubmed.ncbi.nlm.nih.gov/9619787
https://pubmed.ncbi.nlm.nih.gov/9619787
Publikováno v:
Pharmaceutical research. 12(6)
To measure the molecular mobility of amorphous pharmaceutical solids below their glass transition temperatures (Tg), using indomethacin, poly (vinyl pyrrolidone) (PVP) and sucrose as model compounds.Differential scanning calorimetry (DSC) was used to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2fc9ac78c19ddcc4a7e562be5142f775
https://pubmed.ncbi.nlm.nih.gov/7667182
https://pubmed.ncbi.nlm.nih.gov/7667182
Autor:
B C, Hancock, G, Zografi
Publikováno v:
Pharmaceutical research. 11(4)
The glass transition temperature of an amorphous pharmaceutical solid is a critical physical property which can dramatically influence its chemical stability, physical stability, and viscoelastic properties. Water frequently acts as a potent plastici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0787c8cc0f10cbdb2460e1f6476505f7
https://pubmed.ncbi.nlm.nih.gov/8058600
https://pubmed.ncbi.nlm.nih.gov/8058600
Autor:
B C, Hancock, G, Zografi
Publikováno v:
Pharmaceutical research. 10(9)
The limitations of traditional gas adsorption models for describing water vapor sorption by amorphous pharmaceutical solids are described and an alternative approach based on polymer solution theories is proposed. The approach is tested by comparing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::644f2daee118e0b83c364a6582438dd3
https://pubmed.ncbi.nlm.nih.gov/8234160
https://pubmed.ncbi.nlm.nih.gov/8234160